The essence of being an animal: sponge allorecognition and the evolution of individuality. The human genome encodes the ability to recognise self from nonself at the cellular level. In medicine, this innate ability results in the rejection of transplanted (grafted) tissues from unrelated individuals. This project seeks to get to the evolutionary foundation of self-nonself recognition by studying this process in a simple and tractable model - a sponge from the Great Barrier Reef. Like humans, spo ....The essence of being an animal: sponge allorecognition and the evolution of individuality. The human genome encodes the ability to recognise self from nonself at the cellular level. In medicine, this innate ability results in the rejection of transplanted (grafted) tissues from unrelated individuals. This project seeks to get to the evolutionary foundation of self-nonself recognition by studying this process in a simple and tractable model - a sponge from the Great Barrier Reef. Like humans, sponges reject cells and tissues derived from another individual. By defining the genetic basis of self-recognition in sponges we reveal the antiquity of this system and the core features of histocompatibility and immunity. Such insights can inform a range of regenerative medical pursuits.Read moreRead less
Variation in larval gene expression in a marine invertebrate: implications for population divergence via differential settlement response. Evolutionary and ecological functional genomics is an emerging field that integrates gene profiling technologies with experimental and field approaches of ecology and evolution. I take this approach to address a key problem in marine invertebrate biology: how do larvae respond to their environment and how does variation in this response influence the distribu ....Variation in larval gene expression in a marine invertebrate: implications for population divergence via differential settlement response. Evolutionary and ecological functional genomics is an emerging field that integrates gene profiling technologies with experimental and field approaches of ecology and evolution. I take this approach to address a key problem in marine invertebrate biology: how do larvae respond to their environment and how does variation in this response influence the distribution and evolution of a species? I will use a marine gastropod (abalone) model, for which there exists substantial development and population genetic data, and established aquaculture methodologies. Outcomes of this study will enhance knowledge of the stock structure of this and other commercial fisheries, as well as aquaculture efficiency.Read moreRead less
Special Research Initiatives - Grant ID: SR0354638
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Innovative science for sustainable use of marine biodiversity goods and services. Development of new scientific tools and technologies provide expanded opportunities for marine biological research in Australia. An urgent need is to coordinate research scientists and institutions to ensure maximum benefits and to meet Australia's obligations under UNCLOS. The primary goal of this proposed Network is to develop research programs of international significance, through the establishment of new teams ....Innovative science for sustainable use of marine biodiversity goods and services. Development of new scientific tools and technologies provide expanded opportunities for marine biological research in Australia. An urgent need is to coordinate research scientists and institutions to ensure maximum benefits and to meet Australia's obligations under UNCLOS. The primary goal of this proposed Network is to develop research programs of international significance, through the establishment of new teams of Australia's leading marine scientists, mathematical modelers and economists that transcend traditional disciplinary, institutional and geographic boundaries. Our goal is to add focus, scale and scope to an enduring program of innovative research development, leading to world leadership in marine resource management.Read moreRead less
Does mate choice play a role in the fertilization ecology of free-spawners? Botanists have long recognised the consequences of differential compatibility between mates for breeding programs and agriculture. In important aquaculture species such as abalone and sea-urchins, similar variation in mate compatibility has been observed but current theory struggles to explain this variation and its consequences. I have identified a new explanation for this variation and will test this explanation using ....Does mate choice play a role in the fertilization ecology of free-spawners? Botanists have long recognised the consequences of differential compatibility between mates for breeding programs and agriculture. In important aquaculture species such as abalone and sea-urchins, similar variation in mate compatibility has been observed but current theory struggles to explain this variation and its consequences. I have identified a new explanation for this variation and will test this explanation using a marine invertebrate that is a model system for study around the world. A positive result offers promise of explaining how females 'select' mates in free-spawning species and explaining the consequence of this mate selection.Read moreRead less