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Investigation of the biology of insulin-like growth factor 1 and its derivatives for the development of new therapeutics. This project will investigate the biology of insulin-like growth factor 1, a key molecule in growth, development and, in particular, the wound healing process. Its success will lead to improved treatments for non-healing (chronic) wounds and, potentially, new anti-cancer treatments.
Bioactive Polymers for Wound Healing Applications. VitroGroR is a growth factor complex which enhances cell growth and migration, and hence has great potential for treating wounds. Tissue Therapies, which holds the rights to commercialization of VitroGroR, is seeking to develop methods of delivering VitroGroR in its active form to the wound environment. Two solutions to this problem will be developed in this project; a bioactive bandage containing a novel combination of microspheres and a hydrog ....Bioactive Polymers for Wound Healing Applications. VitroGroR is a growth factor complex which enhances cell growth and migration, and hence has great potential for treating wounds. Tissue Therapies, which holds the rights to commercialization of VitroGroR, is seeking to develop methods of delivering VitroGroR in its active form to the wound environment. Two solutions to this problem will be developed in this project; a bioactive bandage containing a novel combination of microspheres and a hydrogel matrix, and secondly an in-situ polymerisable matrix for treatment of deep wounds. The growth factor complex will be protected from aggressive proteases through encapsulation within microspheres, and the use of MMP-inhibiting comonomers.Read moreRead less
Transdermal penetration of corticosteroids in the dog. Topical application of corticosteroids enhances drug concentration and effectiveness in the treatment of skin diseases. Most topical corticosteroid preparations have been developed for human use and are poorly efficacious or promote a high incidence of adverse effects in dogs. This project will characterize corticosteroid penetration through canine skin to permit the development of suitable topical formulations to more effectively control ....Transdermal penetration of corticosteroids in the dog. Topical application of corticosteroids enhances drug concentration and effectiveness in the treatment of skin diseases. Most topical corticosteroid preparations have been developed for human use and are poorly efficacious or promote a high incidence of adverse effects in dogs. This project will characterize corticosteroid penetration through canine skin to permit the development of suitable topical formulations to more effectively control skin diseases in the dog. Skin diseases are a significant problem in veterinary science and this project will not only provide an effective therapeutic option, but also reduce animal (and client) distress when suffering skin disease and/or adverse effects from traditional therapy.Read moreRead less
From exploration to mining: new geological strategies for sustaining high levels of copper production from the Mount Isa district. Mineral production at the Mount Isa copper and Ernest Henry copper-gold mines is worth more than $ 1 billion per year and this has underpinned the northern Queensland economy for a number of years. These resources are being depleted at a high rate, and no significant new discoveries have been made in over a decade. This project will provide some of the tools to defin ....From exploration to mining: new geological strategies for sustaining high levels of copper production from the Mount Isa district. Mineral production at the Mount Isa copper and Ernest Henry copper-gold mines is worth more than $ 1 billion per year and this has underpinned the northern Queensland economy for a number of years. These resources are being depleted at a high rate, and no significant new discoveries have been made in over a decade. This project will provide some of the tools to define new resources for the next generation, ensuring the prosperity of the region and bolstering the Australian economy. The timing is critical given the long lead time between discovery and production (in the order of 5 to 10 years). If successful the research may have major financial impacts at local, regional and national scales. It may also improve mine safety.Read moreRead less
Fundamental experimental and modelling studies of slag/matte/metal/gas systems in support of sustainable copper smelting and converting technologies. Australia is in the midst of a sustained increase in demand for its mineral resources that is leading to expansion in production and major capital investments across the industry sector. Most of the primary production of copper metal in Australia takes place through the use of high temperature smelting technologies. New technologies and significant ....Fundamental experimental and modelling studies of slag/matte/metal/gas systems in support of sustainable copper smelting and converting technologies. Australia is in the midst of a sustained increase in demand for its mineral resources that is leading to expansion in production and major capital investments across the industry sector. Most of the primary production of copper metal in Australia takes place through the use of high temperature smelting technologies. New technologies and significant changes to existing smelting technologies are currently underway; driven by the need to improve both productivity and environmental performance. This research partnership will provide important fundamental information about the complex chemistries of these high temperature processes. This project will assist these process improvements and will provide competitive advantage to Australian industry.Read moreRead less
Improvements in the pyrometallurgical processing of nickel oxide and laterite ores at QNI Yabulu, North Queensland. The QNI Yabulu operation in Queensland is an important supplier of nickel and cobalt metals to the export market. The company is planning to expand the scale of the operations but is faced with two important sustainability issues. One is the recent changes to the European regulations that require very low levels of residual nickel oxide in the nickel metal product. The second issue ....Improvements in the pyrometallurgical processing of nickel oxide and laterite ores at QNI Yabulu, North Queensland. The QNI Yabulu operation in Queensland is an important supplier of nickel and cobalt metals to the export market. The company is planning to expand the scale of the operations but is faced with two important sustainability issues. One is the recent changes to the European regulations that require very low levels of residual nickel oxide in the nickel metal product. The second issue relates to ensuring the supply and improved recovery of nickel and cobalt from oxide-based ores. Further fundamental scientific information is required to provide improved understanding of the complex chemical reactions occurring during the high temperature treatment of these materials, and to guide improvements in product quality, recovery and process efficiencyRead moreRead less
ADVANCED THERMODYNAMIC AND PROCESS MODELS FOR HIGH TEMPERATURE METAL SMELTING TECHNOLOGIES - A COLLABORATIVE RESEARCH PROGRAM IN PYROMETALLURGY. This 5-year ARC Linkage project developed by the Pyrometallurgy Research Centre, UQ brings together several consortia of major mineral companies in a genuinely collaborative way to address a range of complex technical problems associated with the high temperature chemical processing of minerals and metals.
The UQ research team brings new state-of-the- ....ADVANCED THERMODYNAMIC AND PROCESS MODELS FOR HIGH TEMPERATURE METAL SMELTING TECHNOLOGIES - A COLLABORATIVE RESEARCH PROGRAM IN PYROMETALLURGY. This 5-year ARC Linkage project developed by the Pyrometallurgy Research Centre, UQ brings together several consortia of major mineral companies in a genuinely collaborative way to address a range of complex technical problems associated with the high temperature chemical processing of minerals and metals.
The UQ research team brings new state-of-the-art research methodologies, and experimental and computer modelling techniques to provide scientifically important research outcomes which can be used by the industry. The research program will provide fundamental thermodynamic and physical property information on the complex chemical systems encountered in industrial processes, powerful computer models, and applied research outputs for industry. The project will also importantly provide research training in the field pyrometallurgy, deliver competitive advantage to the Australian mineral industry and bring economic benefits particularly to regional Australia.
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Relationship between melanosome distribution and skin colour. This work seeks to examine how the colour of our skin is related to the distribution of melanosomes. This work may allow us to better understand how to develop novel therapies that may alter skin colour and provide protection from the sun (frontier technologies) but may also, in the longer term, lead to healthier approaches to skin management - especially for ageing skin.
Development of a new stochastic short-term production scheduling optimisation approach for open pit metal mines. Stochastic short-term production scheduling (STPS) in open pit mines provides a new framework allowing production schedules to manage risk robustly despite uncertainties in geological and mining conditions. STPS depends on both mining (stockpiling process, multiple ore types and processors, waste production, equipment mobility, feasible sequencing) and geological (in-situ ore variabil ....Development of a new stochastic short-term production scheduling optimisation approach for open pit metal mines. Stochastic short-term production scheduling (STPS) in open pit mines provides a new framework allowing production schedules to manage risk robustly despite uncertainties in geological and mining conditions. STPS depends on both mining (stockpiling process, multiple ore types and processors, waste production, equipment mobility, feasible sequencing) and geological (in-situ ore variability, geological uncertainty, simulated 'future' grade control data) factors. Formulations require development of innovative stochastic goal programming techniques and high-order spatial stochastic simulations. STPS has a major impact on multi-million dollar mining cash flows and affects environmental sustainability. This project represents a strategic priority for some of Australia's largest mining companies.Read moreRead less
Development of carbohydrate-based drug delivery systems. Chronic skin disorders affect 5% of the population. Treatment is challenging and long term because these disorders are chronic and unpredictable. Currently the most potent therapies for psoriasis are administered systemically. Long term usage of these therapies causes side effects such as kidney or liver damage. This proposal describes a new approach to the topical treatment of psoriasis where potent drugs are linked to a hyaluronan sca ....Development of carbohydrate-based drug delivery systems. Chronic skin disorders affect 5% of the population. Treatment is challenging and long term because these disorders are chronic and unpredictable. Currently the most potent therapies for psoriasis are administered systemically. Long term usage of these therapies causes side effects such as kidney or liver damage. This proposal describes a new approach to the topical treatment of psoriasis where potent drugs are linked to a hyaluronan scaffold molecule and are directly applied to the diseased tissue. Advantages of this approach include targeted drug delivery mediated by hyaluronan receptor processes and potential amelioration of the observed drug toxicities.Read moreRead less