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Bioactive Polymers for Wound Healing Applications. VitroGroR is a growth factor complex which enhances cell growth and migration, and hence has great potential for treating wounds. Tissue Therapies, which holds the rights to commercialization of VitroGroR, is seeking to develop methods of delivering VitroGroR in its active form to the wound environment. Two solutions to this problem will be developed in this project; a bioactive bandage containing a novel combination of microspheres and a hydrog ....Bioactive Polymers for Wound Healing Applications. VitroGroR is a growth factor complex which enhances cell growth and migration, and hence has great potential for treating wounds. Tissue Therapies, which holds the rights to commercialization of VitroGroR, is seeking to develop methods of delivering VitroGroR in its active form to the wound environment. Two solutions to this problem will be developed in this project; a bioactive bandage containing a novel combination of microspheres and a hydrogel matrix, and secondly an in-situ polymerisable matrix for treatment of deep wounds. The growth factor complex will be protected from aggressive proteases through encapsulation within microspheres, and the use of MMP-inhibiting comonomers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
Naturally Photoactive Biopolymers. The basic aim of this project is to assess the viability of using semiconducting biopolymers from the melanin family of macromolecules in photoactive device based applications. In order to do this, key optical, structural, electronic, and photochemical properties will be assessed on thin films in the solid state. The melanins are the only known semiconducting biopolymers, and are non-toxic, biocompatible and biodegradable. Their use as ?active? materials in ....Naturally Photoactive Biopolymers. The basic aim of this project is to assess the viability of using semiconducting biopolymers from the melanin family of macromolecules in photoactive device based applications. In order to do this, key optical, structural, electronic, and photochemical properties will be assessed on thin films in the solid state. The melanins are the only known semiconducting biopolymers, and are non-toxic, biocompatible and biodegradable. Their use as ?active? materials in solid state or photo-electrochemical devices has never before been suggested. Specifically, these materials could be used as the light harvesting components in dye sensitised Gratzel cells, or, as the donor material in soft solid photovoltaic junctions. The melanins are also a key class of biomolecules (their involvement in skin cancers is well documented), and hence, any advancement in our understanding of their functions and properties could have biological importance.Read moreRead less
The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and ....The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and legislative motivation for reducing fuel emissions, the development of new Mg-based alloys capable of meeting this demand from automotive manufacturers represents both a potentially large economic advantage to the country of development as well as helping to address the environmental concern about fuel emissions.Read moreRead less
Photoactive Semiconducting Biopolymers. The basic aims of this project are to elucidate, manipulate, and utilise the unique chemical and physical properties of a class of biopolymers called the melanins. These materials are the only known solid state semiconducting biopolymers, and are non-toxic, biocompatible, and biodegradable. Their use as active components in biomimetic soft electonic, optoelectronic or photovoltaic devices, has not hitherto been demonstrated. It is anticipated that the k ....Photoactive Semiconducting Biopolymers. The basic aims of this project are to elucidate, manipulate, and utilise the unique chemical and physical properties of a class of biopolymers called the melanins. These materials are the only known solid state semiconducting biopolymers, and are non-toxic, biocompatible, and biodegradable. Their use as active components in biomimetic soft electonic, optoelectronic or photovoltaic devices, has not hitherto been demonstrated. It is anticipated that the key outcomes from the project will be a demonstration of biopolymer-based photoelectrochemical and solid-state p-i-n solar cells, and an improved understanding of the physics and chemistry of these important biological macromolecules.Read moreRead less
Titanium Alloy Scaffolds for Osseointegration Implant Materials. Australians' life expectancies are among the highest in the world. Degeneration of load bearing bones in the elderly of age 65 and over often requires the inception of biomaterial implants. For the hip and knee replacements alone, there are over 52,000 operations performed in Australia each year at an estimated cost of over $500 million. The success of these procedures depends on the implant biomaterials. The outcomes of this proje ....Titanium Alloy Scaffolds for Osseointegration Implant Materials. Australians' life expectancies are among the highest in the world. Degeneration of load bearing bones in the elderly of age 65 and over often requires the inception of biomaterial implants. For the hip and knee replacements alone, there are over 52,000 operations performed in Australia each year at an estimated cost of over $500 million. The success of these procedures depends on the implant biomaterials. The outcomes of this project are a new category of porous bone implant materials for load bearing applications.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100049
Funder
Australian Research Council
Funding Amount
$2,906,992.00
Summary
Nanofluidic Membranes for Sustainable Energy Future. This project aims to create a novel class of advanced membranes by making fundamental breakthroughs in nanofluidics, and harnessing this for developing new renewable energy and low-energy separation technologies. This project addresses the key challenges in understanding selective mass transport at the angstrom scale, thereby allowing the development of innovative materials design strategies to realise the ultrafast molecular and ionic permeat ....Nanofluidic Membranes for Sustainable Energy Future. This project aims to create a novel class of advanced membranes by making fundamental breakthroughs in nanofluidics, and harnessing this for developing new renewable energy and low-energy separation technologies. This project addresses the key challenges in understanding selective mass transport at the angstrom scale, thereby allowing the development of innovative materials design strategies to realise the ultrafast molecular and ionic permeation, and the ultrahigh selectivities observed in biological cell membranes. This new cross-disciplinary research will benefit Australia by the development of new materials for accelerating renewable hydrogen and biofuel futures, and enabling sustainable production of energy materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100115
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploi ....High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploit interfacial phenomena and to tailor processing-microstructure-composition correlations, so as to design new materials with the best performance possible. Probes with unique capabilities will measure surface morphology, optical properties, elemental composition and crystallographic phase.The facility will be the first in Australia to offer a comprehensive study of structure and properties at high temperature.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0211014
Funder
Australian Research Council
Funding Amount
$337,000.00
Summary
Electron Microscope/X-Ray Unit Equipment Upgrade.
The aim of this proposal is to obtain funding to upgrade major equipment items in the centralised Electron Microscope / X-Ray Unit to replace obsolete instruments, some of which are twenty two years old. The proposed equipment will support highly productive research groups and individuals from the departments of Biology, Chemistry, Chemical Engineering, Civil Engineering, Geography, Geology, Mechanical Engineering and Medical Sciences.
It w ....Electron Microscope/X-Ray Unit Equipment Upgrade.
The aim of this proposal is to obtain funding to upgrade major equipment items in the centralised Electron Microscope / X-Ray Unit to replace obsolete instruments, some of which are twenty two years old. The proposed equipment will support highly productive research groups and individuals from the departments of Biology, Chemistry, Chemical Engineering, Civil Engineering, Geography, Geology, Mechanical Engineering and Medical Sciences.
It will be of great assistance in projects as diverse as the development of new ceramic materials, waste water precipitation chemistry, ore deposit geology, increasing agricultural productivity and the ultrastructure of organs responsible for the sense of balance.
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Studies on metal dusting : reaction mechanisms and their control. Gases which are supersaturated with carbon can react at high temperatures with steels and nickel-base alloys to destroy them, producing a dust of carbon plus metal and/or metal carbides. The mechanism is not properly understood, and the rate of the process impossible to predict. This program will dissect the mechanism using kinetic studies and electron microscopy of precisely located parts of the reacting system. Ways of controll ....Studies on metal dusting : reaction mechanisms and their control. Gases which are supersaturated with carbon can react at high temperatures with steels and nickel-base alloys to destroy them, producing a dust of carbon plus metal and/or metal carbides. The mechanism is not properly understood, and the rate of the process impossible to predict. This program will dissect the mechanism using kinetic studies and electron microscopy of precisely located parts of the reacting system. Ways of controlling the process via alloy compositional changes will be explored.Read moreRead less