Validating And Optimising The Analysis Of Magnetic Resonance Physiology Data
Funder
National Health and Medical Research Council
Funding Amount
$91,725.00
Summary
Combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is used to detect the anatomical areas in the brain that show electrical activity. Several centres worldwide use this technique to localise the seizure focus in patients with epilepsy. However, there is a lack of validation of the currently applied techniques. Current analysis methods have been developed and validated for other fMRI paradigms, such as motor tasks. It is not known whether the same principles ar ....Combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is used to detect the anatomical areas in the brain that show electrical activity. Several centres worldwide use this technique to localise the seizure focus in patients with epilepsy. However, there is a lack of validation of the currently applied techniques. Current analysis methods have been developed and validated for other fMRI paradigms, such as motor tasks. It is not known whether the same principles are applicable and optimal for fMRI-EEG data. The proposed project aims at validating and optimising the analysis strategies for fMRI-EEG data.Read moreRead less
The Identification Of A Novel NIDDM Susceptibility Gene Localised To Human Chromosome 12q
Funder
National Health and Medical Research Council
Funding Amount
$438,055.00
Summary
Non-insulin dependent diabetes mellitus (adult-onset diabetes) is very common in Australia and is a major public health problem. It is a leading cause of kidney failure, blindness, heart attacks, strokes and amputations. Over 3% of the Australian population have adult-onset diabetes, and very few Australians have not been touched in some way by the shadow of diabetes. The precise cause of diabetes is unknown, however we do know that it tends to run in families, indicating that an inherited tende ....Non-insulin dependent diabetes mellitus (adult-onset diabetes) is very common in Australia and is a major public health problem. It is a leading cause of kidney failure, blindness, heart attacks, strokes and amputations. Over 3% of the Australian population have adult-onset diabetes, and very few Australians have not been touched in some way by the shadow of diabetes. The precise cause of diabetes is unknown, however we do know that it tends to run in families, indicating that an inherited tendency is important. By finding genes which cause diabetes we have the opportunity to unravel much of the mystery of this condition. This research program will find genes which cause diabetes by searching for them in large pedigrees in which many family members are affected by diabetes. Finding the genes which cause diabetes will have a significant impact in at least three major ways. Firstly, it will increase our understanding of the disease process. Secondly, it will be possible to develop tests to identify people at risk of diabetes at a very early stage so that therapy can be introduced and complications averted. Thirdly, it will be possible to develop new and more effective approaches for the prevention and treatment of diabetes.Read moreRead less
Microtubule Cytoskeleton In Tumourigenesis And Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$612,885.00
Summary
Over one million cases of lung cancer are diagnosed each year worldwide, making this the leading cause of cancer death. Advanced non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancer cases. We have identified a protein called ?III-tubulin that is often highly expressed in aggressive and drug resistant NSCLC, and is involved in tumour formation. We will examine how ?III-tubulin is working and identify ways to target this protein to stop tumour growth.
Directed assembly and photoelectric properties of core-shell nanowire networks of PbSe-TiO2 heterostructures for high efficiency low-cost solar cells. The proposed program is aimed at studying numerous fundamental properties and phenomena of photoelectrochemical cells that have an important impact on environmentally friendly solutions to energy problems. Specifically, solar cells have a significant role in energy markets and in lessening CO2 emissions and other environmental impacts. Solar cell ....Directed assembly and photoelectric properties of core-shell nanowire networks of PbSe-TiO2 heterostructures for high efficiency low-cost solar cells. The proposed program is aimed at studying numerous fundamental properties and phenomena of photoelectrochemical cells that have an important impact on environmentally friendly solutions to energy problems. Specifically, solar cells have a significant role in energy markets and in lessening CO2 emissions and other environmental impacts. Solar cell technology, coupled with renewable energy sources, has the potential to provide a long-term solution to the energy crisis and the global warming threat. In addition, the strong team to be assembled will reach a leading position in this area of cutting edge technology. The outcomes will benefit Australian industries.Read moreRead less
A Mathematical Approach to Flexible Management of Open Pit Mines with Uncertain Geology and Unpredictable Demand. This project will create new mathematical algorithms to flexibly manage open pit mining projects. The development of strategic plans for mining operations is a highly complex task, based on incomplete geological information and uncertain future commodity demand. The smart mathematics we create will allow Australia to capitalise on upturns in international demand, while limiting unavo ....A Mathematical Approach to Flexible Management of Open Pit Mines with Uncertain Geology and Unpredictable Demand. This project will create new mathematical algorithms to flexibly manage open pit mining projects. The development of strategic plans for mining operations is a highly complex task, based on incomplete geological information and uncertain future commodity demand. The smart mathematics we create will allow Australia to capitalise on upturns in international demand, while limiting unavoidable negative outcomes, by flexibly adjusting the mining operation to prevailing geological and economic conditions. Australia's mineral exports are worth over $50b annually to the Australian economy. Our techniques will better manage Australia's mining projects and capture new, emerging markets, significantly impacting on Australia's balance of trade.Read moreRead less
NUMERICAL MODELS OF PLATE TECTONICS, MANTLE CONVECTION AND SLAB DYNAMICS WITH EVOLVING FAULTS. We plan to develop a method for simulating large-scale
geological structures with a much improved treatment
of tectonic faults in 3D.
Current computer models have sharp geological faults at plate
boundaries represented by broad, blurred zones. New techniques
for modeling cracks in engineering structures will be scaled up to
the whole Earth.
This will help us to understand how the Earth's p ....NUMERICAL MODELS OF PLATE TECTONICS, MANTLE CONVECTION AND SLAB DYNAMICS WITH EVOLVING FAULTS. We plan to develop a method for simulating large-scale
geological structures with a much improved treatment
of tectonic faults in 3D.
Current computer models have sharp geological faults at plate
boundaries represented by broad, blurred zones. New techniques
for modeling cracks in engineering structures will be scaled up to
the whole Earth.
This will help us to understand how the Earth's plates move and
interact now and in the past and how the structure of the continents
arose.
Not only is this intrinsically interesting, it
will also be of immediate practical benefit to geological modelers.Read moreRead less