Targeting RCAN1 To Treat Type 2 Diabetes And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$814,468.00
Summary
Obesity and impaired insulin secretion are significant contributors to Type 2 diabetes. In this project we demonstrate that a protein called RCAN1 contributes to both fat mass and insulin secretion and that this contribution is exacerbated in obesity and in Type 2 diabetes. We will identify how RCAN1 controls these major metabolic pathways with outcomes including the development of new therapeutics for obesity and Type 2 diabetes.
ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the ....ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the financial system. It will enable Australian research in this area to match the scale and impact of similar research in other major international financial centres, and play an essential role in placing Australia among the world's leaders in financial markets related research.Read moreRead less
Special Research Initiatives - Grant ID: SR0354466
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Mathematics in Contemporary Science. The Mathematics in Contemporary Science Research Network brings contemporary methods of non-linear analysis and differential equations, geometric reasoning and relevant algebraic and topological ideas to enrich six application areas in modern science: Complex Systems, Computer Vision, Optimal Transportation, Nanotechnology, Physics and Shortest Networks. MiCS will develop both the mathematics and the application areas in parallel. It will focus on postgradu ....Mathematics in Contemporary Science. The Mathematics in Contemporary Science Research Network brings contemporary methods of non-linear analysis and differential equations, geometric reasoning and relevant algebraic and topological ideas to enrich six application areas in modern science: Complex Systems, Computer Vision, Optimal Transportation, Nanotechnology, Physics and Shortest Networks. MiCS will develop both the mathematics and the application areas in parallel. It will focus on postgraduate training through workshops, summer schools and web based resources and build long-term international collaborations with EU networks and NSERC, NSF and EPSRC institutes as well as bringing together academic and industry leaders.Read moreRead less
Advanced matrix-analytic methods with applications. Over the last twenty-five years, matrix-analytic methods have proved to be very successful in formulating and analysing certain classes of stochastic models. Motivated by applications, this project will investigate more advanced matrix-analytic methods than have hitherto been studied.
The culture of implementing Freedom of Information in Australia. In partnership with three Australian Information Commissioners/Ombudsmen this project aims to map the culture of administering Freedom of Information (FOI) laws across a number of Australian jurisdictions. The study aspires to capture and analyse the attitudes among FOI practitioners, government agency managements and political leaders toward information access implementation. The project aims to provide the partner organisations w ....The culture of implementing Freedom of Information in Australia. In partnership with three Australian Information Commissioners/Ombudsmen this project aims to map the culture of administering Freedom of Information (FOI) laws across a number of Australian jurisdictions. The study aspires to capture and analyse the attitudes among FOI practitioners, government agency managements and political leaders toward information access implementation. The project aims to provide the partner organisations with an increased understanding of the culture of administering FOI to inform training/awareness programs and campaigns in order to increase the functionality of FOI. Well-functioning access to information systems is crucial both for good governance and Australia's participation in the digital economy.
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Transport of metals in vapours and brines: new insights into the formation of the Earth's mineral deposits. Traditional models for the formation of hydrothermal ore deposits assume that aqueous fluids transported the metals. This view is challenged by new observations showing that gold and copper are preferentially enriched in vapours coexisting with salty aqueous fluids in some deposits. This project uses state-of-the-art techniques and develops new instruments to measure experimentally the par ....Transport of metals in vapours and brines: new insights into the formation of the Earth's mineral deposits. Traditional models for the formation of hydrothermal ore deposits assume that aqueous fluids transported the metals. This view is challenged by new observations showing that gold and copper are preferentially enriched in vapours coexisting with salty aqueous fluids in some deposits. This project uses state-of-the-art techniques and develops new instruments to measure experimentally the partitioning of metals between solid, fluid and vapour at temperatures typical for natural ore deposits (350-550C, pressures varying for vapour saturated to 1 kb). By improving our understanding of metal transport within the Earth's crust, these data will lead to improved models and technologies for exploring and processing base and precious metals.Read moreRead less
Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
Housing energy efficiency transitions. This project aims to provide an analysis of housing retrofit and its links with household energy costs. It includes householders across eight global urban sites, as well as the businesses that supply retrofit services. The project will analyse the retrofit experience of both energy poor and other households, providing an internationally significant evidence base. Outcomes include a robust empirical evidence base on the implications of retrofit for househol ....Housing energy efficiency transitions. This project aims to provide an analysis of housing retrofit and its links with household energy costs. It includes householders across eight global urban sites, as well as the businesses that supply retrofit services. The project will analyse the retrofit experience of both energy poor and other households, providing an internationally significant evidence base. Outcomes include a robust empirical evidence base on the implications of retrofit for households to tailor actions that will shape the lives of residents in Australian households.Read moreRead less
Local Government and Housing in Australia for the 21st Century. This project plans to analyse survey data, qualitative interviews and detailed case studies to investigate and theorise trends in the relationship between local government and housing supply and demand. It aims to answer a number of questions: What is the role of local government in housing Australians in the 21st century? How have changing economic, social, demographic and political processes affected the interaction between local ....Local Government and Housing in Australia for the 21st Century. This project plans to analyse survey data, qualitative interviews and detailed case studies to investigate and theorise trends in the relationship between local government and housing supply and demand. It aims to answer a number of questions: What is the role of local government in housing Australians in the 21st century? How have changing economic, social, demographic and political processes affected the interaction between local government and housing over the past decades, and what are the likely impacts in the future? How might a reshaped Australian Federation recast the role of local government in this area of social and economic policy? The research aims to consider inner urban, suburban and regional and rural areas; and to contribute to a healthier and more productive Australia by providing local governments with evidence on their role in the housing market and how they can prepare for the future.Read moreRead less