Muir Torre Syndrome: The Role Of IHC And Genotyping In Sebaceous Neoplasia To Facilitate Prevention Strategies In Colorectal And Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,786.00
Summary
Sebaceous neoplasia (SN), may be an early warning sign for Lynch syndrome (LS), an inherited cancer predisposition caused by mutations in a group of genes. There are high lifetime risks of bowel and uterine cancer, for which there are effective risk management plans if the risk is known. Clinicians are challenged by the role of SN in identifying LS. At present, it is hard to differentiate. We aim to determine features to improve the diagnosis of LS carriers.
Biomarker-driven Applications Of Immunotherapy In Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Immunotherapy is a new treatment strategy that works in many different lymphoma types but there is no successful method of predicting response or selecting patients. I aim to explore use of immunotherapy in 3 key lymphoma subtypes to identify new techniques for predicting which patients respond to treatment through prospective biomarker research using novel techniques. These aims will be achieved through a series of clinical trials of immunotherapy in lymphoma all with a biomarker research focus
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and ....The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and legislative motivation for reducing fuel emissions, the development of new Mg-based alloys capable of meeting this demand from automotive manufacturers represents both a potentially large economic advantage to the country of development as well as helping to address the environmental concern about fuel emissions.Read moreRead less
The early tectonic evolution of the Curnamona Province. This project aims to test the hypothesis that the Curnamona Province preserves evidence for an extension-related structural geology architecture. This will allow a comparison of the basin evolution, crustal architecture and mechanisms of basin development between the Curnamona Province and well-understood basins of the Mount Isa Inlier. The project is expected to add value to pre-existing databases, and deliver a plate tectonic and str ....The early tectonic evolution of the Curnamona Province. This project aims to test the hypothesis that the Curnamona Province preserves evidence for an extension-related structural geology architecture. This will allow a comparison of the basin evolution, crustal architecture and mechanisms of basin development between the Curnamona Province and well-understood basins of the Mount Isa Inlier. The project is expected to add value to pre-existing databases, and deliver a plate tectonic and structural framework to interpret basin evolution and constrain geochronology/geochemical analysis, and develop a three-dimesional crustal architecture. The results will provide new constraints on the evolution of the Australian plate, and how the Australian crust has evolved.Read moreRead less
Accurate calibration and interpretation of airborne electromagnetic data. There is increasing interest in using airborne electromagnetic (AEM) data to explore structural features hidden beneath the earth's surface. At present, 2D images of these features can be built up using approximate 1D models that predict electrical conductivity. This research will develop 2D models that allow accurate imaging of 3D structures. Applications include mineral and diamond exploration, the mapping of leakage fro ....Accurate calibration and interpretation of airborne electromagnetic data. There is increasing interest in using airborne electromagnetic (AEM) data to explore structural features hidden beneath the earth's surface. At present, 2D images of these features can be built up using approximate 1D models that predict electrical conductivity. This research will develop 2D models that allow accurate imaging of 3D structures. Applications include mineral and diamond exploration, the mapping of leakage from tailings dams, and more precise mapping of dryland salinity. The project also aims to develop a method to calibrate AEM systems, leading to more accurate environmental mapping and significant long-term economic benefits.Read moreRead less
Coupled subduction dynamics and continent deformations: understanding the Asian and Red Sea tectonics. Modeling slab pull forces and lithospheric deformation provides a new insight in the dynamics of plate tectonics. Unraveling the self-consistent formation of faults, rifts, shear zones and up to passive margin will further the understanding of our planet. Furthermore the application of these models to specific geological contexts will support the exploration and assessment of inaccessible Ear ....Coupled subduction dynamics and continent deformations: understanding the Asian and Red Sea tectonics. Modeling slab pull forces and lithospheric deformation provides a new insight in the dynamics of plate tectonics. Unraveling the self-consistent formation of faults, rifts, shear zones and up to passive margin will further the understanding of our planet. Furthermore the application of these models to specific geological contexts will support the exploration and assessment of inaccessible Earth's resources, such as hydrocarbons pools, located along the deep Australian continent margins, and diamonds and ore deposits, associated with continental shear zones, which potential is still to be fully discovered.Read moreRead less
Heterobimetallic Coordination Complexes Containing Rare Earth and d-Block Ions. Rare earth compounds have major industrial applications such as MRI contrast agents and as catalysts within the rubber and petroleum industries. The fundamental knowledge ensuing from this project has the potential to produce new and advanced magnetic materials. Nanotechnological industries are being developed in Australia and this research will provide materials with the capacity to act as optical or electrical sw ....Heterobimetallic Coordination Complexes Containing Rare Earth and d-Block Ions. Rare earth compounds have major industrial applications such as MRI contrast agents and as catalysts within the rubber and petroleum industries. The fundamental knowledge ensuing from this project has the potential to produce new and advanced magnetic materials. Nanotechnological industries are being developed in Australia and this research will provide materials with the capacity to act as optical or electrical switches, magnetic storage devices or molecular sensors. This pioneering work will ensure that Australia remains at the forefront of chemical research within the rapidly advancing field of magnetochemistry.Read moreRead less
Expanding Diagnostic Approaches For Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$1,269,355.00
Summary
Currently, there are ~1,000 families who have attended Family Cancer Clinics across Australia who have the hallmarks of having Lynch syndrome, a hereditary bowel cancer syndrome, but who have no gene defect identified, i.e. their cancer is unexplained. Clinicians are challenged by these “Lynch-like” patients as their family cancer risk is unknown. Our research has identified new gene defects in Lynch-like patients. Our aim is to optimise clinical testing approaches for Lynch-like patients.
Improving the Continuous Copper Converting Process Using Ferrous Calcium Silicate Slags. Replacement of refractories due to slag attack is a major cost in the copper making process. Metallurgists need to find a better slag which retains the benefits of current slags but is less aggressive towards refractories. This project will assess the suitability of a newly proposed ferrous calcium silicate slag for continuous copper converting. The outcomes will be to: (1) provide fundamental knowledge of ....Improving the Continuous Copper Converting Process Using Ferrous Calcium Silicate Slags. Replacement of refractories due to slag attack is a major cost in the copper making process. Metallurgists need to find a better slag which retains the benefits of current slags but is less aggressive towards refractories. This project will assess the suitability of a newly proposed ferrous calcium silicate slag for continuous copper converting. The outcomes will be to: (1) provide fundamental knowledge of the properties of the SiO2-CaO-FeO slag system, (2) provide data on the rate and mechanism of refractory attack by this slag and (3) enable the copper smelting industry to assess the potential of this slag to reduce operating costs.Read moreRead less