Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
Muir Torre Syndrome: The Role Of IHC And Genotyping In Sebaceous Neoplasia To Facilitate Prevention Strategies In Colorectal And Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,786.00
Summary
Sebaceous neoplasia (SN), may be an early warning sign for Lynch syndrome (LS), an inherited cancer predisposition caused by mutations in a group of genes. There are high lifetime risks of bowel and uterine cancer, for which there are effective risk management plans if the risk is known. Clinicians are challenged by the role of SN in identifying LS. At present, it is hard to differentiate. We aim to determine features to improve the diagnosis of LS carriers.
Respiratory failure at birth is a major cause of death and disease in newborn infants. At birth the airways must be cleared of liquid to allow the inhalation of air, but, little is known about the process of lung aeration, because it has not been possible to observe or measure it. We have developed imaging and analytical techniques to observed and measure lung aeration. We will determine ventilation procedures that promote uniform lung aeration and minimise lung injury in ventilated infants.
Biomarker-driven Applications Of Immunotherapy In Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Immunotherapy is a new treatment strategy that works in many different lymphoma types but there is no successful method of predicting response or selecting patients. I aim to explore use of immunotherapy in 3 key lymphoma subtypes to identify new techniques for predicting which patients respond to treatment through prospective biomarker research using novel techniques. These aims will be achieved through a series of clinical trials of immunotherapy in lymphoma all with a biomarker research focus
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and ....The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and legislative motivation for reducing fuel emissions, the development of new Mg-based alloys capable of meeting this demand from automotive manufacturers represents both a potentially large economic advantage to the country of development as well as helping to address the environmental concern about fuel emissions.Read moreRead less
'Streamlining search and destroy': development of a robust prioritisation framework for weed eradication using Hawkweed species. Introduced species are one of the greatest threats to our biodiversity and agriculture, as evidenced by the ARC’s National Research Priority: Safeguarding Australia. This project will advance Australia’s ability to protect itself from invaders by developing tools that guide cost-effective detection and response. Our project will have a direct effect on the planning a ....'Streamlining search and destroy': development of a robust prioritisation framework for weed eradication using Hawkweed species. Introduced species are one of the greatest threats to our biodiversity and agriculture, as evidenced by the ARC’s National Research Priority: Safeguarding Australia. This project will advance Australia’s ability to protect itself from invaders by developing tools that guide cost-effective detection and response. Our project will have a direct effect on the planning and management of Hawkweed control in Victoria and New South Wales. The framework delivered will have direct application to numerous other weeds (and relevance to other pests and diseases) within and beyond Australia. Read moreRead less
The early tectonic evolution of the Curnamona Province. This project aims to test the hypothesis that the Curnamona Province preserves evidence for an extension-related structural geology architecture. This will allow a comparison of the basin evolution, crustal architecture and mechanisms of basin development between the Curnamona Province and well-understood basins of the Mount Isa Inlier. The project is expected to add value to pre-existing databases, and deliver a plate tectonic and str ....The early tectonic evolution of the Curnamona Province. This project aims to test the hypothesis that the Curnamona Province preserves evidence for an extension-related structural geology architecture. This will allow a comparison of the basin evolution, crustal architecture and mechanisms of basin development between the Curnamona Province and well-understood basins of the Mount Isa Inlier. The project is expected to add value to pre-existing databases, and deliver a plate tectonic and structural framework to interpret basin evolution and constrain geochronology/geochemical analysis, and develop a three-dimesional crustal architecture. The results will provide new constraints on the evolution of the Australian plate, and how the Australian crust has evolved.Read moreRead less
Accurate calibration and interpretation of airborne electromagnetic data. There is increasing interest in using airborne electromagnetic (AEM) data to explore structural features hidden beneath the earth's surface. At present, 2D images of these features can be built up using approximate 1D models that predict electrical conductivity. This research will develop 2D models that allow accurate imaging of 3D structures. Applications include mineral and diamond exploration, the mapping of leakage fro ....Accurate calibration and interpretation of airborne electromagnetic data. There is increasing interest in using airborne electromagnetic (AEM) data to explore structural features hidden beneath the earth's surface. At present, 2D images of these features can be built up using approximate 1D models that predict electrical conductivity. This research will develop 2D models that allow accurate imaging of 3D structures. Applications include mineral and diamond exploration, the mapping of leakage from tailings dams, and more precise mapping of dryland salinity. The project also aims to develop a method to calibrate AEM systems, leading to more accurate environmental mapping and significant long-term economic benefits.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100257
Funder
Australian Research Council
Funding Amount
$446,857.00
Summary
Molecular biosecurity: Genomic databanks for managing new pest invasions. This project aims to develop a set of genomics-based approaches for analysing new pest invasions. By producing and analysing genomic databanks for four insect pest species, including three that have recently invaded Australia, this project expects to identify invasion origins and to track new pest incursions within Australia. The project should also provide insights into pest ecology, including movement rates and populatio ....Molecular biosecurity: Genomic databanks for managing new pest invasions. This project aims to develop a set of genomics-based approaches for analysing new pest invasions. By producing and analysing genomic databanks for four insect pest species, including three that have recently invaded Australia, this project expects to identify invasion origins and to track new pest incursions within Australia. The project should also provide insights into pest ecology, including movement rates and population change over time. This information can enable more efficient deployment of biosecurity resources and pave the way for genomics to be used pre-emptively to stop new invasions. This can help make genomics a go-to response to new pest invasions and position Australia at the forefront of genomics-based pest biosecurity.Read moreRead less