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An Examination Of The Relationship Between Alcohol-related Injury (ARI) And Licensed Premises
Funder
National Health and Medical Research Council
Funding Amount
$78,686.00
Summary
There is growing interest in acute alcohol-related problems, and especially injuries. These are often experienced by young people, frequently as a consequence of intoxication or drinking in unsafe settings. Little work has been undertaken in Australia to systematically examined alcohol-related injuries (ARIs). This study will examine ARIs, identify the frequency with which such problems present to a local hospital, record the nature of the injuries, details of the person sustaining it, and the d ....There is growing interest in acute alcohol-related problems, and especially injuries. These are often experienced by young people, frequently as a consequence of intoxication or drinking in unsafe settings. Little work has been undertaken in Australia to systematically examined alcohol-related injuries (ARIs). This study will examine ARIs, identify the frequency with which such problems present to a local hospital, record the nature of the injuries, details of the person sustaining it, and the drinking location. Characteristics of drinking locations and drinking settings, in particular licensed premises, will be examined to determine their association with ARIs. Then an intervention will be undertaken in conjunction with local police, to address the conditions of the drinking environment with the aim of reducing ARIs and other alcohol-related problems stemming from licensed premises. The intervention will form part of a randomised controlled trial where licensed premises, identified through monthly police data as hot spots, receive either an intervention or act as a control. In the following month, controls receive the intervention (a cross-over design). The intervention was established in 1998 by Gold Coast police and involves police, fire and liquor licensing officers undertaking an on-site inspection and taking prescribed actions. It is hypothesised that this action should result in a decreased level of ARIs being generated from premises which receive the intervention, compared to those that do not. This is an intersectoral, collaborative project aimed at improving community safety through a concerted effort by police, health and the licensees.Read moreRead less
Investigating The Role Of The UPF3B Gene And Nonsense Mediated RNA Decay (NMD) Process In Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$572,710.00
Summary
Intellectual disability is a frequent and important medical problem. Genetic and environmental factors contribute about equally to the aetiology of intellectual disability. Estimated 1-3% of population suffer from a form of intellectual disability. Among the genetic factors contributing to intellectual disability are genes, and their mutations, on one of the human chromosomes, chromosome X. We have been studying human X-chromosome genes for many years and discovered in excess of 20 novel genes c ....Intellectual disability is a frequent and important medical problem. Genetic and environmental factors contribute about equally to the aetiology of intellectual disability. Estimated 1-3% of population suffer from a form of intellectual disability. Among the genetic factors contributing to intellectual disability are genes, and their mutations, on one of the human chromosomes, chromosome X. We have been studying human X-chromosome genes for many years and discovered in excess of 20 novel genes causing various forms of intellectual disability. Surprisingly the number of genes, in which mutations cause various forms of intellectual disability is unexpectedly high. Just on the human X-chromosome we expect in excess of 200 such genes, which is nearly 30% of the gene content of this chromosome. We propose to study a novel gene, UPF3B, we recently identified to be mutated in a form of intellectual disability. The normal function of this gene and its protein is known to a certain extent. The UPF3B protein plays a role of a guardian of other genes in human (and also other species) cells. The role of the UPF3B protein is to prevent erroneous genetic information to be used for the building of proteins with potentially toxic effects to the organism. In our patients this process clearly malfunctions as a consequence of the damaged UPF3B gene. We propose to shed some more light in to the molecular intricacies of this process with the aim to better understand the mechanics of the process. Families, which participate in our studies and have this gene involved will benefit from the availability of direct test. Multiple other families around the world are also likely to benefit, now or in the future.Read moreRead less
Predicting Renal, Ophthalmic And Heart Events In The Aboriginal Community: The PROPHECY Diabetes Multi-Omics Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$3,955,505.00
Summary
Diabetes is at epidemic levels in Indigenous Australians, impairing quality of life, and contributing to poor health. This is a result of rapid development of kidney, heart and eye complications. We have established a large long-term population study among Aboriginal communities within South Australia and will explore the burden, natural history and the social, psychological, environmental, clinical and genomic predictors of diabetes and its complications.
To what extent does Australian food policy consider its health impact. This research will examine how public policies relating to food can be made healthier. The diet of Australians currently contributes to high rates of disease including diabetes, heart disease and the underlying issue of obesity. It will examine Australian agriculture and food processing, manufacturing and marketing and the environmental impacts of these sectors. The research will analyse policy documents and interview key peo ....To what extent does Australian food policy consider its health impact. This research will examine how public policies relating to food can be made healthier. The diet of Australians currently contributes to high rates of disease including diabetes, heart disease and the underlying issue of obesity. It will examine Australian agriculture and food processing, manufacturing and marketing and the environmental impacts of these sectors. The research will analyse policy documents and interview key people involved in each sector to determine their views on the ways in which our food supply affects our health. It will result in policy recommendations advising how the Australian food sector can be made more supportive of health and equity. Policy makers will be engaged with our findings through a Food Policy Summit. Read moreRead less
Understanding marine biodiversity across vast spatial scales. Large-scale studies of biodiversity are frequently recommended by ecologists, but their costs are prohibitive. More efficient, yet accurate, sampling and analytical procedures are needed. This proposal will provide new quantitative knowledge on patterns of diversity of marine species (fish & invertebrates) from local to regional scales across southern Australia and northern New Zealand. An innovative feature of this research is the c ....Understanding marine biodiversity across vast spatial scales. Large-scale studies of biodiversity are frequently recommended by ecologists, but their costs are prohibitive. More efficient, yet accurate, sampling and analytical procedures are needed. This proposal will provide new quantitative knowledge on patterns of diversity of marine species (fish & invertebrates) from local to regional scales across southern Australia and northern New Zealand. An innovative feature of this research is the contribution of new ecological information with novel analytical procedures to identify the consequences of using more cost-effective techniques on quantifying patterns of biodiversity. This understanding is fundamental to the on-going advancement of ecology and conservation biology.Read moreRead less
Does A Health In All Policies Approach Improve Health, Well-being And Equity?
Funder
National Health and Medical Research Council
Funding Amount
$968,325.00
Summary
This project will develop understanding of complex policy initiatives for health & well being which operate across government departments. It will do this through a case study of the SA Government’s Health in All Policies approach which aims to get government departments to develop policies which build a healthier population and reduce health inequities. This research will assess that process, report on what helps and hinders and develop research methods suitable for complex policy evaluation.
Discovery Indigenous Researchers Development - Grant ID: DI110100037
Funder
Australian Research Council
Funding Amount
$105,756.00
Summary
Intersectoral collaboration and capacity building for better outcomes for Aboriginal people in Port Augusta. This project will contribute to improved outcomes in governance, inclusion and intersectoral collaboration within organisations and institutions in Port Augusta, South Australia in order that they can better address the social determinants of health as they affect Aboriginal people.
Implementing guidelines to prevent chronic disease in the community. The burden of chronic disease in Australia has resulted in prevention of chronic disease being an important priority for the Australian health system. High quality evidence for preventing chronic disease exists; however the practice falls short of the evidence. Finding ways to implement the evidence for preventing chronic disease is an urgent national need. This study aims to apply the evidence for preventing chronic disease in ....Implementing guidelines to prevent chronic disease in the community. The burden of chronic disease in Australia has resulted in prevention of chronic disease being an important priority for the Australian health system. High quality evidence for preventing chronic disease exists; however the practice falls short of the evidence. Finding ways to implement the evidence for preventing chronic disease is an urgent national need. This study aims to apply the evidence for preventing chronic disease in practice. It will generate data and validate a model on how to effectively improve the uptake of guidelines by both practitioners and consumers. This project is of national and community benefit because it will enable the potential of preventing chronic disease to be realised.Read moreRead less
Nickel iron sulphide mineralogy: the link between mineral transformations and microstructure and magnetic properties. This project is about measuring the rate at which minerals transform or react and how metal diffusion controls these reactions. Metal diffusion in sulphides is much more rapid that in silicates and is still very significant at low temperatures (< 300 C). In this project, we are trying to measure the rate at which the principal ore of nickel, pentlandite, transforms to violarite ....Nickel iron sulphide mineralogy: the link between mineral transformations and microstructure and magnetic properties. This project is about measuring the rate at which minerals transform or react and how metal diffusion controls these reactions. Metal diffusion in sulphides is much more rapid that in silicates and is still very significant at low temperatures (< 300 C). In this project, we are trying to measure the rate at which the principal ore of nickel, pentlandite, transforms to violarite, another important nickel rich sulphide that forms from it in the upper parts of ore bodies. The arrangement of the metal atoms in these minerals is sensitive to temperature, so it may be used as a geothermometer.Read moreRead less