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Supporting Informed Choice For Management Of Screen Detected Ductal Carcinoma In Situ (DCIS) Among Older Women (70 Years And Over)
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
DCIS refers to abnormal changes in the breast that may or may not lead to breast cancer later on. Screening women over 70 means more DCIS will be found and treated by surgery, radiotherapy, and other treatments. To avoid unnecessary treatment, some DCIS patients could instead have regular checks (monitoring). This research will develop a tool to help women over 70 with DCIS to make an informed choice between monitoring or immediate treatment, and test whether this improves their quality of life.
Novel Mechanism Underlying The Behavioural And Neurocognitive Deficits In Children With Sleep Disorders.
Funder
National Health and Medical Research Council
Funding Amount
$312,296.00
Summary
About one third of Australian children have a sleep disorder. Behavioural or academic problems are common in these children, however the link between sleep and daytime problems is still not clear. New research suggests the pattern of brain activity during deep sleep may provide some answers. This study will explore the link between brain activity during deep sleep and daytime functioning in children with sleep disorders, providing valuable information for treatment.
Use Of Molecular Tumour Markers To Improve Diagnostic Performance Of Bronchoscopy In Assessment Of Pulmonary Nodules And Early Diagnosis Of Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$303,014.00
Summary
Pulmonary nodules may represent early lung cancer though difficulty in accurate diagnosis means many patients experience delayed diagnosis, or unnecessary surgical biopsy or repeat CT imaging (& consequent radiation exposure). I will identify molecular (DNA, protein) markers in bronchoscopic & blood specimens to accurately characterize malignant & benign nodules. These biomarkers will also be investigated for their value as a non-invasive screening test for lung cancer
What Is A Culturally Appropriate Mental Health Service For Aboriginal People?
Funder
National Health and Medical Research Council
Funding Amount
$296,516.00
Summary
This project aims to develop an Aboriginal model of care and a sustainable and culturally safe framework for evaluating the delivery of mental health services to Aboriginal people living with a serious mental illness in an urban setting. Outcomes from this project, because of their transferability, will add significantly to the theoretical and methodological body of knowledge on the delivery of health services to Indigenous people, in WA, Australia and internationally.
Biomarker-driven Applications Of Immunotherapy In Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Immunotherapy is a new treatment strategy that works in many different lymphoma types but there is no successful method of predicting response or selecting patients. I aim to explore use of immunotherapy in 3 key lymphoma subtypes to identify new techniques for predicting which patients respond to treatment through prospective biomarker research using novel techniques. These aims will be achieved through a series of clinical trials of immunotherapy in lymphoma all with a biomarker research focus
Pursuing Health Equity Through The Implementation Of Public Policy: Making The National Disability Scheme Equitable
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Health policies and programs often provide the greatest benefit to those who are well-off, creating greater disparities in health outcomes between different population groups. This study examines how health equity is pursued within the National Disability Insurance Scheme. Using the NDIS as a case study, it will identify ways to support health equity during the implementation of national public policies, thereby contributing to better health outcomes.
Hereditary Non-Polyposis Colorectal Cancer (HNPCC) confers a high lifetime risk of developing cancer, especially colorectal and endometrial cancer. By characterising disease presentation in the patient cohort, HNPCC in an Australian context will be better defined. The aim of this proposal is to undertake a genetic investigation such that a more comprehensive personalised patient risk-assessment can be completed by identifying genes related to disease development.