Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
Deep Coal Mining. The occurrence of progressively larger gas outbursts, coal bumps, and the potential for the catastrophic collapse of coal pillars is of increasing importance as mining drives deeper in seams rich in methane and other hydrocarbons. This study will address this issue by examining the roles of stress level, strain-rate, gas desorption rate, and drained and undrained gas and liquid pressures in the dynamic failure of coal, while simultaneously evaluating the promise and fidelity of ....Deep Coal Mining. The occurrence of progressively larger gas outbursts, coal bumps, and the potential for the catastrophic collapse of coal pillars is of increasing importance as mining drives deeper in seams rich in methane and other hydrocarbons. This study will address this issue by examining the roles of stress level, strain-rate, gas desorption rate, and drained and undrained gas and liquid pressures in the dynamic failure of coal, while simultaneously evaluating the promise and fidelity of a variety of hazard indices and precursive signals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882889
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imper ....History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imperative is seen by scholars and representatives of the nation's major collecting institutions as a primary limiting factor in the contemporary research environment. The project will enhance Australia's reputation as a world leader in the development of web-based information infrastructure to support research and scholarship.Read moreRead less
Developing a new tectonothermal and mineralization history for the Capricorn Orogen, Western Australia: Assisting mineral exploration in greenfields terrains. Successful exploration models rely on the development of a reliable geological framework through which to understand the specific processes responsible for the formation of economic ore deposits. A framework cannot be constructed without robust age data. This Project will apply advanced geochronology, combined with regional- and deposit-sc ....Developing a new tectonothermal and mineralization history for the Capricorn Orogen, Western Australia: Assisting mineral exploration in greenfields terrains. Successful exploration models rely on the development of a reliable geological framework through which to understand the specific processes responsible for the formation of economic ore deposits. A framework cannot be constructed without robust age data. This Project will apply advanced geochronology, combined with regional- and deposit-scale field mapping, to formulate a new and improved stratigraphic and tectonic framework for a prospective greenfields region in Western Australia. Outcomes from this Project will lead to more effective exploration models and thereby better exploration targeting. Reducing uncertainty and risk in exploration is key to the discovery and development of deep Earth resources. Read moreRead less
Predicting Renal, Ophthalmic And Heart Events In The Aboriginal Community: The PROPHECY Diabetes Multi-Omics Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$3,955,505.00
Summary
Diabetes is at epidemic levels in Indigenous Australians, impairing quality of life, and contributing to poor health. This is a result of rapid development of kidney, heart and eye complications. We have established a large long-term population study among Aboriginal communities within South Australia and will explore the burden, natural history and the social, psychological, environmental, clinical and genomic predictors of diabetes and its complications.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347122
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Australian Women's Archives Project (AWAP). Australian Women's Archives Project aims to enhance infrastructure for researchers in the field of women's and gender history by constructing appropriate data bases and a range of other electronic sources of information, and by improving the preservation and accessibility of records and archives relevant to this prominent and growing field. Project outcomes will include support for the production of cutting edge academic historical works and simultaneo ....Australian Women's Archives Project (AWAP). Australian Women's Archives Project aims to enhance infrastructure for researchers in the field of women's and gender history by constructing appropriate data bases and a range of other electronic sources of information, and by improving the preservation and accessibility of records and archives relevant to this prominent and growing field. Project outcomes will include support for the production of cutting edge academic historical works and simultaneously, the significant contribution of an essential information resource base for Australian women.
The Australian Women's Archives Project employs innovative technologies and adheres to state-of-the-art international standards for electronic management of historical information. The roles of AWAP's Chief Investigators reflect the use of these new forms of information management: CIs both create and utilise the products of each others' collaborative historical research.
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Neoproterozoic global geodynamic and climatic events: were they linked? This project will study a unique cluster of global geodynamic and climatic events 850-700 million years ago that will help us to understand the interactions between the Earth's deep mantle, its crust, and its atmospheric climate. Academic values aside, the work will bring direct benefit to the Australian industry. Knowledge on the distribution of the Neoproterozoic plume events will provide new exploration targets for Ni-Cu- ....Neoproterozoic global geodynamic and climatic events: were they linked? This project will study a unique cluster of global geodynamic and climatic events 850-700 million years ago that will help us to understand the interactions between the Earth's deep mantle, its crust, and its atmospheric climate. Academic values aside, the work will bring direct benefit to the Australian industry. Knowledge on the distribution of the Neoproterozoic plume events will provide new exploration targets for Ni-Cu-PGE and V-Ti deposits. Better constrained palaeogeography will help to locate mineral-rich crustal provinces that were once connected. Understanding climatic consequences of global geodynamic events will help to better understand and respond to climate changes. Read moreRead less
Evolution of the Proterozoic lithosphere and its bearing of sediment hosted base metal mineralisation. This project aims to determine the aspects of lithospheric evolution that led to a concentration of giant base metal mineral deposits in the Early to Middle Proterozoic (ca 1.9-1.5 billion years ago). We propose to test three related hypotheses that, if validated, will fundamentally change our view of Proterozoic metallogenesis and the way the mineral industry approaches exploration for these ....Evolution of the Proterozoic lithosphere and its bearing of sediment hosted base metal mineralisation. This project aims to determine the aspects of lithospheric evolution that led to a concentration of giant base metal mineral deposits in the Early to Middle Proterozoic (ca 1.9-1.5 billion years ago). We propose to test three related hypotheses that, if validated, will fundamentally change our view of Proterozoic metallogenesis and the way the mineral industry approaches exploration for these deposits.Read moreRead less
Defects and Deformation in Olivine: From Molecules to Mantle. This project establishes the role of hydrogen in controlling olivine deformation, plate tectonics and mantle geodynamics. The unique application of innovative nanoscale simulation, microscale observation and geophysical characterisation ensures that results will have far-reaching impact in the Australian and International Earth Science community. In particular, our results will enable greater understanding of water migration in the m ....Defects and Deformation in Olivine: From Molecules to Mantle. This project establishes the role of hydrogen in controlling olivine deformation, plate tectonics and mantle geodynamics. The unique application of innovative nanoscale simulation, microscale observation and geophysical characterisation ensures that results will have far-reaching impact in the Australian and International Earth Science community. In particular, our results will enable greater understanding of water migration in the mantle, the formation of deep Earth mineral resources and lead to significant improvements in the interpretation of geophysical variations in Earth's lithosphere.Read moreRead less
The Early Stages of Granite Evolution: Extraction and Transport Through Ductile Crust . This research is aimed at understanding how the continents develop through several stages of rock melting. Rock melts deep in the continents to form granite magmas which rise, transporting to the upper crust important metals, such as gold, copper and tin, and heat producing elements such as uranium, thorium and potassium. This research proposal seeks to understand how granite melts form and rise transporting ....The Early Stages of Granite Evolution: Extraction and Transport Through Ductile Crust . This research is aimed at understanding how the continents develop through several stages of rock melting. Rock melts deep in the continents to form granite magmas which rise, transporting to the upper crust important metals, such as gold, copper and tin, and heat producing elements such as uranium, thorium and potassium. This research proposal seeks to understand how granite melts form and rise transporting these all important elements, which control not only our wealth but also the stability of the continents we live in.Read moreRead less