Targeting Bone Marrow Mediated Angiogenesis And Metastasis In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$463,006.00
Summary
Despite advances in treatment and diagnostics breast cancer (BC) remains one of the leading causes of death in women. Metastases and tumour blood vessel recruitment are linked. Work by Dr Mellick and others has shown that host bone marrow contributes endothelial progenitor cells (EPCs) to tumour vasculature. The chemokines and their receptors, which differentiate EPCs from tumour vessels, will be knocked down in the tumour cells and EPC progenitors with the aim of preventing tumour spread.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882889
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imper ....History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imperative is seen by scholars and representatives of the nation's major collecting institutions as a primary limiting factor in the contemporary research environment. The project will enhance Australia's reputation as a world leader in the development of web-based information infrastructure to support research and scholarship.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347122
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Australian Women's Archives Project (AWAP). Australian Women's Archives Project aims to enhance infrastructure for researchers in the field of women's and gender history by constructing appropriate data bases and a range of other electronic sources of information, and by improving the preservation and accessibility of records and archives relevant to this prominent and growing field. Project outcomes will include support for the production of cutting edge academic historical works and simultaneo ....Australian Women's Archives Project (AWAP). Australian Women's Archives Project aims to enhance infrastructure for researchers in the field of women's and gender history by constructing appropriate data bases and a range of other electronic sources of information, and by improving the preservation and accessibility of records and archives relevant to this prominent and growing field. Project outcomes will include support for the production of cutting edge academic historical works and simultaneously, the significant contribution of an essential information resource base for Australian women.
The Australian Women's Archives Project employs innovative technologies and adheres to state-of-the-art international standards for electronic management of historical information. The roles of AWAP's Chief Investigators reflect the use of these new forms of information management: CIs both create and utilise the products of each others' collaborative historical research.
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Cementitious gel: the missing link in understanding the ageing of built infrastructure. Exposure of built reinforced concrete infrastructure to coastal environments causes premature ageing, unplanned remediation and reduced safety. Enhanced forecasting, achieved by advanced methods, including Helium Ion Microscopy and modeling interactions between cement gel, chloride and water, will deliver proactive management of ageing assets.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100115
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploi ....High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploit interfacial phenomena and to tailor processing-microstructure-composition correlations, so as to design new materials with the best performance possible. Probes with unique capabilities will measure surface morphology, optical properties, elemental composition and crystallographic phase.The facility will be the first in Australia to offer a comprehensive study of structure and properties at high temperature.Read moreRead less
A fast and effective automated insider threat detection and prediction system. Threats from insiders directly compromises the security, privacy and integrity of Australian e-commerce, large databases and communication channels. This project will provide an essential step in combating this criminal activity by developing methods to detect such threats and secure the public's information against exposure and identity theft.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775533
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
A New Generation Noble Gas Mass Spectrometer Facility for Advanced Research in the Earth, Planetary and Environmental Sciences. The current proposal, to establish a new Noble Gas Analytical Consortium for noble gas chronological and geochemical analyses, will generate new knowledge on the evolution of the Earth, with profound implications for past climate change, landscape evolution, formation of ore bodies, and terrestrial geodynamics. Consequently, the facility will conform to the National Res ....A New Generation Noble Gas Mass Spectrometer Facility for Advanced Research in the Earth, Planetary and Environmental Sciences. The current proposal, to establish a new Noble Gas Analytical Consortium for noble gas chronological and geochemical analyses, will generate new knowledge on the evolution of the Earth, with profound implications for past climate change, landscape evolution, formation of ore bodies, and terrestrial geodynamics. Consequently, the facility will conform to the National Research Priority of 'An Environmentally Sustainable Australia'. The new facility will ensure that Australian research remains at the forefront of international science development and will also provide essential training for the next generation of Australian scientists.Read moreRead less
X-ray tomographic analysis and modelling of metallurgical coke. This project will apply 3D X-ray micro-tomography and model-based computational analysis to develop innovative approaches to the micro-structural characterisation of metallurgical coke. This has significant ramifications for the iron industry since coke characterisation is of primary importance to improved blast furnace productivity. The project will deliver new quantitative indices of coke microstructure, develop models for simulat ....X-ray tomographic analysis and modelling of metallurgical coke. This project will apply 3D X-ray micro-tomography and model-based computational analysis to develop innovative approaches to the micro-structural characterisation of metallurgical coke. This has significant ramifications for the iron industry since coke characterisation is of primary importance to improved blast furnace productivity. The project will deliver new quantitative indices of coke microstructure, develop models for simulation of micro-structural properties and coke transport properties, and examine coke reactivity in 3D contexts. This project will also be the first study to use multi-scale 3D X-ray tomographic analysis to examine the structural dynamics of coke during both its production and its use in the blast furnace.Read moreRead less
Understanding and reversing the habitat shifts that have endangered the broad-headed snake. Extinction rates for vertebrate species are higher in southern Australia than almost anywhere else in the world, and saving endangered taxa is critical to biodiversity conservation. To do this effectively, researchers need to understand the processes that threaten wild populations, and to develop novel solutions to those problems in close collaboration with wildlife management authorities and other stake ....Understanding and reversing the habitat shifts that have endangered the broad-headed snake. Extinction rates for vertebrate species are higher in southern Australia than almost anywhere else in the world, and saving endangered taxa is critical to biodiversity conservation. To do this effectively, researchers need to understand the processes that threaten wild populations, and to develop novel solutions to those problems in close collaboration with wildlife management authorities and other stakeholders. This project will build such an understanding and collaboration, focusing on an endangered snake species. We propose ambitious landscape-scale field experiments that will simultaneously test hypotheses on threatening processes, and restore habitat quality to reverse population declines.Read moreRead less