Exploring The Function Of Breast Cancer-Associated Variants In Long Non-Coding RNAs
Funder
National Health and Medical Research Council
Funding Amount
$501,585.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel a ....Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel avenues for therapy.Read moreRead less
Gene Expression Profiling In Critically Ill Patients With Septic Shock: The ADRENAL-GEPS Study
Funder
National Health and Medical Research Council
Funding Amount
$863,304.00
Summary
Sepsis refers to a whole body inflammation caused by severe infection. Approximately one in three adults admitted with septic shock die within 28 days and it is unclear whether treatment with anti-inflammatory drugs is beneficial in terms of patient survival. The aim of this study is to develop a clinical test based on gene activity that can be used to predict patient survival and also determine what the best treatment might be for individual patients.
Identifying Novel Long-noncoding RNAs Involved In The Development Of Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$785,204.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. The aim of this proposal is to identify and characterise these non-coding genes that are modulate breast cancer risk. Understanding how sequences variations that alter these novel genes contribute to breast cancer will provide novel avenues for therapy.
Fixed and variable-length segment vocoders for very low bitrate speech coding. Reliable and secure voice communication is an important aspect of military and defence operations. In order to reduce the possibility of interception, low power transmitters are normally used for radio communications, where the bandwidth is often very low. Military voice communication, therefore, requires the coding of speech at very low bitrates. Our research proposal aims to develop speech coders that can operate ....Fixed and variable-length segment vocoders for very low bitrate speech coding. Reliable and secure voice communication is an important aspect of military and defence operations. In order to reduce the possibility of interception, low power transmitters are normally used for radio communications, where the bandwidth is often very low. Military voice communication, therefore, requires the coding of speech at very low bitrates. Our research proposal aims to develop speech coders that can operate at lower bitrates and reproduce speech of high quality and intelligibility. This is highly beneficial to the defence forces of Australia as it will permit the use of high-grade encryption technology to improve the security of transmission.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882889
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imper ....History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imperative is seen by scholars and representatives of the nation's major collecting institutions as a primary limiting factor in the contemporary research environment. The project will enhance Australia's reputation as a world leader in the development of web-based information infrastructure to support research and scholarship.Read moreRead less
New lattice approach for digital broadband communications. A main limiting factor in supplying future broadband communications is overcoming signal dispersion in the transmission channel. Recent preliminary collaboration by the chief investigators has uncovered a novel approach to this problem based on powerful mathematical lattice theory. The techniques have potential to significantly increase bandwidth and reliability compared to current technologies. This project will use lattice theory to pr ....New lattice approach for digital broadband communications. A main limiting factor in supplying future broadband communications is overcoming signal dispersion in the transmission channel. Recent preliminary collaboration by the chief investigators has uncovered a novel approach to this problem based on powerful mathematical lattice theory. The techniques have potential to significantly increase bandwidth and reliability compared to current technologies. This project will use lattice theory to propose, develop, analyse and test new data transmission techniques including joint coding, modulation and equalisation. The research will include theoretical analysis and hardware implementation. The overall aim is to dramatically improve reliability and throughput of data communication systems.Read moreRead less
Non-viral Vectors For Targeted Delivery Of RNAi Nucleotides To Cervical Cancers
Funder
National Health and Medical Research Council
Funding Amount
$415,738.00
Summary
RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using ....RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using RNA interference we can turn off the expression of these two genes which results in the death of the cancer cell. We are also able to cure mice of tumours derived from human cervical cancer. The major issue with gene silencing is how to deliver it effectively to patients. Here we are investigating novel nanoparticulate systems to deliver this new gene-inhibiting drugs preferentially to the tumour site.Read moreRead less
From exploration to mining: new geological strategies for sustaining high levels of copper production from the Mount Isa district. Mineral production at the Mount Isa copper and Ernest Henry copper-gold mines is worth more than $ 1 billion per year and this has underpinned the northern Queensland economy for a number of years. These resources are being depleted at a high rate, and no significant new discoveries have been made in over a decade. This project will provide some of the tools to defin ....From exploration to mining: new geological strategies for sustaining high levels of copper production from the Mount Isa district. Mineral production at the Mount Isa copper and Ernest Henry copper-gold mines is worth more than $ 1 billion per year and this has underpinned the northern Queensland economy for a number of years. These resources are being depleted at a high rate, and no significant new discoveries have been made in over a decade. This project will provide some of the tools to define new resources for the next generation, ensuring the prosperity of the region and bolstering the Australian economy. The timing is critical given the long lead time between discovery and production (in the order of 5 to 10 years). If successful the research may have major financial impacts at local, regional and national scales. It may also improve mine safety.Read moreRead less
Fundamental experimental and modelling studies of slag/matte/metal/gas systems in support of sustainable copper smelting and converting technologies. Australia is in the midst of a sustained increase in demand for its mineral resources that is leading to expansion in production and major capital investments across the industry sector. Most of the primary production of copper metal in Australia takes place through the use of high temperature smelting technologies. New technologies and significant ....Fundamental experimental and modelling studies of slag/matte/metal/gas systems in support of sustainable copper smelting and converting technologies. Australia is in the midst of a sustained increase in demand for its mineral resources that is leading to expansion in production and major capital investments across the industry sector. Most of the primary production of copper metal in Australia takes place through the use of high temperature smelting technologies. New technologies and significant changes to existing smelting technologies are currently underway; driven by the need to improve both productivity and environmental performance. This research partnership will provide important fundamental information about the complex chemistries of these high temperature processes. This project will assist these process improvements and will provide competitive advantage to Australian industry.Read moreRead less
A new methodology for the measurement of transition metals ions in complex, high temperature oxide systems relevant to non-ferrous metal production. Complex multi-component molten oxide phases, known commonly as slags, are used in the high temperature production and refining of metals. The slag systems of commercial interest contain transition metals species, such as, Fe2+, Fe3+. Each of these species behaves as if it were a separate chemical component. Researchers at the University of Queensla ....A new methodology for the measurement of transition metals ions in complex, high temperature oxide systems relevant to non-ferrous metal production. Complex multi-component molten oxide phases, known commonly as slags, are used in the high temperature production and refining of metals. The slag systems of commercial interest contain transition metals species, such as, Fe2+, Fe3+. Each of these species behaves as if it were a separate chemical component. Researchers at the University of Queensland have developed a new methodolgy, which enables the concentrations of these transition metal ions to be measured.
These types of measurements cannot be made with any of the techniques currently in use. The study will provide data on high temperature slags in a number of industrially and scientifically important systems. This approach will be applicable to a wide range of chemical systems in the fields of extractive metallurgy, materials science and geology; systems which could not previously be characterised.Read moreRead less