The sponge genome project and the evolution of multicellularity: using comparative genomics and developmental biology to reconstruct the first animals. Recently the entire genome from a living fossil - a sponge from the Great Barrier Reef - was sequenced (jointly supported by the ARC and US Department of Energy). As this genome is assembled and analysed, many of the fundamental biological processes that underlie the construction and evolution of all animals, including humans, will be revealed. ....The sponge genome project and the evolution of multicellularity: using comparative genomics and developmental biology to reconstruct the first animals. Recently the entire genome from a living fossil - a sponge from the Great Barrier Reef - was sequenced (jointly supported by the ARC and US Department of Energy). As this genome is assembled and analysed, many of the fundamental biological processes that underlie the construction and evolution of all animals, including humans, will be revealed. In addition, sponge genomics will fuel innovations in medicine and biotechnology. Specifically, sponges are renowned for their capacity to synthesise bioactive compounds used in drug development, and high-grade silica used for semi-conductor construction. This project will identify the gene networks controlling these biosynthetic processes.Read moreRead less
Variation in larval gene expression in a marine invertebrate: implications for population divergence via differential settlement response. Evolutionary and ecological functional genomics is an emerging field that integrates gene profiling technologies with experimental and field approaches of ecology and evolution. I take this approach to address a key problem in marine invertebrate biology: how do larvae respond to their environment and how does variation in this response influence the distribu ....Variation in larval gene expression in a marine invertebrate: implications for population divergence via differential settlement response. Evolutionary and ecological functional genomics is an emerging field that integrates gene profiling technologies with experimental and field approaches of ecology and evolution. I take this approach to address a key problem in marine invertebrate biology: how do larvae respond to their environment and how does variation in this response influence the distribution and evolution of a species? I will use a marine gastropod (abalone) model, for which there exists substantial development and population genetic data, and established aquaculture methodologies. Outcomes of this study will enhance knowledge of the stock structure of this and other commercial fisheries, as well as aquaculture efficiency.Read moreRead less
Testing indicators of genetic exchange and adaptation of populations, essential for biodiversity assessment and management. There will be diverse benefits from our testing and improvement of genetic indicators for exchange between populations and adaptive differentiation of populations. Managers and population biologists will have confidence in choice and use of these vital tools in sustainable use of our terrestrial and aquatic bioresources, as recommended by the federal State of Environment s ....Testing indicators of genetic exchange and adaptation of populations, essential for biodiversity assessment and management. There will be diverse benefits from our testing and improvement of genetic indicators for exchange between populations and adaptive differentiation of populations. Managers and population biologists will have confidence in choice and use of these vital tools in sustainable use of our terrestrial and aquatic bioresources, as recommended by the federal State of Environment system. Also, the use of these tools to identify differential genetic adaptations is the first step in bioprospecting, as well as revealing the raw material for natural and artificial populations to adapt to changes: soil loss, salinity, acidity, climate change. Forensic genetics will benefit from the improved tools for defining subpopulations.Read moreRead less
Endocardial sprouting and mechano-signalling in heart trabeculation. This project aims to understand how the ventricles, the pumping chambers of the mammalian heart, form during embryonic life. Critical is the elaboration of trabeculae, myocardial projections that form a sponge-like layer on the inner surface of the chamber wall and which play vital roles in contraction, oxygen and nutrient exchange, conduction and septation. The project expects to develop a deeper understanding of trabeculation ....Endocardial sprouting and mechano-signalling in heart trabeculation. This project aims to understand how the ventricles, the pumping chambers of the mammalian heart, form during embryonic life. Critical is the elaboration of trabeculae, myocardial projections that form a sponge-like layer on the inner surface of the chamber wall and which play vital roles in contraction, oxygen and nutrient exchange, conduction and septation. The project expects to develop a deeper understanding of trabeculation using high resolution, single cell methodologies, and to investigate how bio-mechanical forces from contraction or blood flow influence chambers formation.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
The function of menin in mammalian development. This project aims to determine the role of a ubiquitous transcriptional co-regulator, menin, in mammalian development. Mice that lack menin through targeted deletion of the gene die during embryogenesis, but the cause is unknown, although is likely to be due to the abnormal expression of genes usually regulated by this factor. We will determine which genes are inappropriately expressed and responsible for the accompanying developmental defects. Thi ....The function of menin in mammalian development. This project aims to determine the role of a ubiquitous transcriptional co-regulator, menin, in mammalian development. Mice that lack menin through targeted deletion of the gene die during embryogenesis, but the cause is unknown, although is likely to be due to the abnormal expression of genes usually regulated by this factor. We will determine which genes are inappropriately expressed and responsible for the accompanying developmental defects. This knowledge will help us understand the process of development in mammals, including birth defects in humans.Read moreRead less
Chromatin barriers in Plasmodium falciparum gene regulation. Malaria is a major world disease that kills around 2 million people annually. The genome of the causative agent has now been completely sequenced, but we still know very little of how and why some genes are activated while their neighbours are turned off. I will study the DNA barriers that separate such genes, and the proteins that interact with these regions to better understand how genetic regulation functions in these parasites. A b ....Chromatin barriers in Plasmodium falciparum gene regulation. Malaria is a major world disease that kills around 2 million people annually. The genome of the causative agent has now been completely sequenced, but we still know very little of how and why some genes are activated while their neighbours are turned off. I will study the DNA barriers that separate such genes, and the proteins that interact with these regions to better understand how genetic regulation functions in these parasites. A better understanding of gene regulation in malaria parasites will help us to better combat the tricks utilised by this and other organisms to elude our immune systems.Read moreRead less