Endothelial Development From Pluripotent Stem Cells As A Means To Study Pathology In Pulmonary Artery Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$613,311.00
Summary
Pulmonary artery hypertension (PAH) is a fatal disease primarily affecting young adults. It is caused by a defect in cells that form the vessel that carries blood from the heart to the lungs. We will use stem cells made from the skin of PAH patients to examine why the blood vessel cells from these patients fail to function normally.
Engineering the Microstructure of Electrodes for Advanced Fuel Cells. A polymer solution-based integration technique is proposed to be developed to fabricate polymer electrolyte membrane fuel cells, allowing for effective engineering of the porous networks and interfaces within electrodes and cells. This novel systems materials engineering approach is expected to overcome the drawbacks of the conventional hot pressing method, enabling precise integration of nanostructured electrodes and membrane ....Engineering the Microstructure of Electrodes for Advanced Fuel Cells. A polymer solution-based integration technique is proposed to be developed to fabricate polymer electrolyte membrane fuel cells, allowing for effective engineering of the porous networks and interfaces within electrodes and cells. This novel systems materials engineering approach is expected to overcome the drawbacks of the conventional hot pressing method, enabling precise integration of nanostructured electrodes and membrane into high-performance, flexible fuel cells. The outcomes of this research aim to provide a unique opportunity for Australia to become a world leader in the rapidly-emerging clean energy technology, and critical manufacturing of new energy generation systems for domestic uses and exports, thereby producing important economic benefits.Read moreRead less
Suppression Of NADPH Oxidase-derived Oxidative Stress By Anti-sense Probes And HDL In Human Vascular Endothelium
Funder
National Health and Medical Research Council
Funding Amount
$455,250.00
Summary
In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) develo ....In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) developed in our laboratory, which block a particular gene causing oxidative stress, we will determine whether this gene is responsible for the formation of oxyradicals in human and mouse cells grown in culture. In addition, we will explore whether this gene is turned on by factors known to be involved in CHD. Finally, we will also investigate whether the good cholesterol known as HDL can act to prevent oxidative stress in human cells, as we discovered it appears to do in living arteries in vivo. If we find it has the same protective effect in endothelium, we will determine how it does this, and which component proteins of the HDL particle are important. This might suggest new treatments to prevent acute events leading to heart attack and stroke, and possibly new applications where damage appears to result from acute oxidative stress, such as in the brain soon after a stroke has occurred. We also have a plan to develop antisense drugs that will target the important gene specifically in the affected endothelium. In addition, we have other specific new drugs that will block this system in arteries. Simultaneously we will be testing the role of this gene in mouse and rabbit models of artery disease, for both our types of drugs might provide valuable new therapeutic agents to target the underlying cause of CHD and not just its symptoms as current drugs do.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100637
Funder
Australian Research Council
Funding Amount
$428,154.00
Summary
An integrated electrolyser for CO2 conversion from capture media. This project aims to develop an efficient electrochemical method to convert carbon dioxide (CO2) to valuable chemicals. It expects to displace the energy-costly step of its upstream CO2 capture process. The key novelty is the use of flow-through electrodes and optimal solvents to promote CO2 conversion at high rates. Expected outcomes include enhanced efficiency of CO2 sequestration, and new techniques to develop electrodes with w ....An integrated electrolyser for CO2 conversion from capture media. This project aims to develop an efficient electrochemical method to convert carbon dioxide (CO2) to valuable chemicals. It expects to displace the energy-costly step of its upstream CO2 capture process. The key novelty is the use of flow-through electrodes and optimal solvents to promote CO2 conversion at high rates. Expected outcomes include enhanced efficiency of CO2 sequestration, and new techniques to develop electrodes with well-controlled local reaction environments, which are essential for electrochemical energy conversion and storage. This will benefit Australia's environment and industries such as cement and aluminium manufacturing in managing carbon emissions, and accelerate Australia’s transition to a carbon-neutral economy.Read moreRead less
Low-temperature ceramic electrolysis cells for renewable energy technology. This project aims to develop advanced protonic ceramic electrolysis cells for greatly improving the efficiency of hydrogen production and carbon dioxide conversion using renewable energy. This will be achieved by nanoscale integration of proton-conducting two-dimensional materials with solid acids and ceramic proton conductors to lower the manufacturing costs and operating temperature of protonic ceramic electrolysis cel ....Low-temperature ceramic electrolysis cells for renewable energy technology. This project aims to develop advanced protonic ceramic electrolysis cells for greatly improving the efficiency of hydrogen production and carbon dioxide conversion using renewable energy. This will be achieved by nanoscale integration of proton-conducting two-dimensional materials with solid acids and ceramic proton conductors to lower the manufacturing costs and operating temperature of protonic ceramic electrolysis cells. Expected outcomes of the project include new intellectual property on materials formulation and process parameters for commercial development of this new type of ceramic electrolysis cell, thereby contributing to the growth of Australian manufacturing and renewable energy industries and reduction of carbon emissions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100084
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Australia’s fuel cells and electrolysers prototyping and testing facility. This project aims to address a major gap in Australian infrastructure for researching and developing technologies for Power to X, including hydrogen production and use. The aspiration is to establish an integrated fuel cell and electrolyser prototyping and testing facility to support Australia’s excellent fundamental research in advanced energy materials, electrocatalysis, and engineering design. The aim is to equip the r ....Australia’s fuel cells and electrolysers prototyping and testing facility. This project aims to address a major gap in Australian infrastructure for researching and developing technologies for Power to X, including hydrogen production and use. The aspiration is to establish an integrated fuel cell and electrolyser prototyping and testing facility to support Australia’s excellent fundamental research in advanced energy materials, electrocatalysis, and engineering design. The aim is to equip the research community with the capability to fabricate electrolyser and fuel cell prototypes at relevant scales to accelerate translational research in these areas. Doing so will also enable the technical and expertise platform needed to support industry's transition toward Australia’s 2050 net zero objective.Read moreRead less
Optimising experimental design for robust product development: a case study for high-efficiency energy generation. This project tackles key mathematical challenges to provide a powerful new methodology and tool for optimal product design, making smarter use of limited information, minimising costly trials, shortening the product cycle, and boosting the competitiveness of both the Australian manufacturing and alternative energy production industries.
Towards ab initio molecular dynamics simulations of proton and electron transfer processes. Electrochemical technologies seek design capabilities to enable the discovery of novel electrolytes with valuable properties. This project will develop new advanced computational methods to understand electron and proton transfer in electrolytes and thereby allow us to enhance performance of electrochemical devices and control metal deposition.
Discovery Early Career Researcher Award - Grant ID: DE230100407
Funder
Australian Research Council
Funding Amount
$462,414.00
Summary
Novel Hydroxide Ion Conductive Membranes for Advanced Ammonia Fuel Cell. This project aims to address a longstanding challenge in the development of direct ammonia fuel cells for utilization of ammonia as a green energy carrier. It proposes to develop advanced hydroxide ion conductive membranes based on novel porous framework materials to achieve high hydroxide ion conductivity and lower ammonia crossover simultaneously, thereby substantially enhancing the energy efficiency of direct ammonia fue ....Novel Hydroxide Ion Conductive Membranes for Advanced Ammonia Fuel Cell. This project aims to address a longstanding challenge in the development of direct ammonia fuel cells for utilization of ammonia as a green energy carrier. It proposes to develop advanced hydroxide ion conductive membranes based on novel porous framework materials to achieve high hydroxide ion conductivity and lower ammonia crossover simultaneously, thereby substantially enhancing the energy efficiency of direct ammonia fuel cells. The proposed research expects to create new knowledge in the fields of membrane science and energy. The successful development of advanced membranes will improve the efficiency of storage of intermittent and fluctuating renewable resources, thereby contributing to the reduction of carbon footprint in Australia. Read moreRead less
Smart utilisation of cobaltite based electrodes on solid oxide fuel cells. This project aims to develop solid oxide fuel cell technologies with significantly simplified fabrication steps and at low cost. It aims to generate fundamental knowledge on the polarisation induced electrode/electrolyte interfaces under fuel cell operation conditions. The advanced fuel cell technologies will in turn substantially increase the energy conversion efficiency and provide significant benefit in the reduction o ....Smart utilisation of cobaltite based electrodes on solid oxide fuel cells. This project aims to develop solid oxide fuel cell technologies with significantly simplified fabrication steps and at low cost. It aims to generate fundamental knowledge on the polarisation induced electrode/electrolyte interfaces under fuel cell operation conditions. The advanced fuel cell technologies will in turn substantially increase the energy conversion efficiency and provide significant benefit in the reduction of greenhouse emission.Read moreRead less