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Research Topic : nicotine
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  • Funded Activity

    Efficacy Of Education And Advice Delivered By Text Message To Aid Smoking Cessation

    Funder
    National Health and Medical Research Council
    Funding Amount
    $538,395.00
    Summary
    A high proportion of smokers indicate a desire to stop smoking and report having made attempts to quit. However, most attempts are not successful and new methods are needed to support motivated smokers and improve success rates. This project evaluates the use of text messages to deliver advice and support to smokers motivated to stop smoking. We aim to understand if and how this promosing new intervention helps smokers to quit.
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    Funded Activity

    An Open-label Randomised Pragmatic Policy Trial Of Nicotine Products For Short-term Cessation Assistance Or Long-term Substitution In Smokers.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,053,910.00
    Summary
    Many smokers who try to quit fail in their attempt. Medicinal nicotine is currently only used as a short-term quit aid. This trial will test if offering smokers the option of using these products as long-term substitutes for cigarettes will help more smokers to successfully quit. We will also determine if offering smokers low toxicity smokeless tobacco and electronic nicotine devices in addition to medicinal nicotine products further increases the number of smokers who quit successfully.
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    Funded Activity

    Impulse Control In Nicotine Use And Dependence

    Funder
    National Health and Medical Research Council
    Funding Amount
    $676,204.00
    Summary
    Nicotine abuse is the single greatest preventable risk factor for physical illness and death in Australians. Our understanding of the neural and cognitive mechanisms that underlie the transition from use to dependence is yet to be understood. The current proposal investigates the neural mechanisms underlying cognitive control, critical to self-control over the impulse for drug rewards, in non-dependent and dependent nicotine users.
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    Funded Activity

    Randomised Trial Of Smoking Cessation Support For Patients With Cancer

    Funder
    National Health and Medical Research Council
    Funding Amount
    $107,405.00
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    Funded Activity

    Public Health Policies And Interventions To Reduce Tobacco-related Harms Among Socially Disadvantaged Populations And ‘low Probability Quitters’

    Funder
    National Health and Medical Research Council
    Funding Amount
    $421,747.00
    Summary
    Tobacco continues to be a leading cause of preventable death and disease in Australia. Those who are socially disadvantaged are at higher risk of smoking, which contributes to the health gap between the rich and poor. This research will provide evidence for policy makers on interventions which could reduce smoking among the most disadvantaged in society. It will also examine whether less harmful nicotine products could a reduce health risks in smokers who find quitting difficult.
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    Funded Activity

    A Novel Knockin Model To Test The Role Of Nicotine Acting On Alpha4 Acetylcholine Receptors In Complex Behaviours

    Funder
    National Health and Medical Research Council
    Funding Amount
    $581,315.00
    Summary
    Cigarette smoking is the single largest preventable cause of death and disease in Australia and worldwide. Nicotine contained in tobacco products acts on brain nicotine receptors, which plays an intrinsic role in addiction. One type of receptor for nicotine found in regions of the brain associated with drug-seeking behaviour is called alpha4 nicotinic receptors. We have made a mouse with a mutation in this nicotine receptor to study nicotine addiction and anxiety.
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    Funded Activity

    Understanding The Impacts Of Vaporised Nicotine Products On Smoking In Australia

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,603,159.00
    Summary
    Vaporised nicotine products (e.g., e-cigarettes) are widely used in Australia, even though possession of the nicotine fluid without a permit is an offence. They are primarily used by smokers as a means of quitting. However, there is concern about their potential attractiveness and uptake by non-smokers. The aim is to identify how these products might be used to both maximise smoking cessation and minimise nicotine use, especially smoking uptake by non-smokers.
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    Funded Activity

    Title: ‘Indigenous Counselling And Nicotine (ICAN) QUIT In Pregnancy’ - A Cluster Randomised Trial To Implement Culturally Competent Evidence-based Smoking Cessation For Pregnant Aboriginal And Torres Strait Islander Smokers

    Funder
    National Health and Medical Research Council
    Funding Amount
    $2,259,016.00
    Summary
    ‘ICAN QUIT in Pregnancy’ tackles smoking through training health providers caring for expectant mothers of Indigenous babies in real-world primary care settings. The intervention was co-developed with Aboriginal communities. We will assess how many Indigenous women, cared for by the trained services, quit smoking, compared to the women that receive usual care. We anticipate that babies born to mothers in the intervention group will have less respiratory illness in their first six months.
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    Funded Activity

    Translating Evidence Based Smoking Cessation Care For Pregnant Indigenous Smokers

    Funder
    National Health and Medical Research Council
    Funding Amount
    $181,065.00
    Summary
    Smoking is a major cause of poor health in mothers and babies, yet smoking rates remain high in Indigenous pregnant women. This fellowship supports a trial of a culturally competent targeted intervention for Indigenous pregnant women who smoke. The intervention provides webinar training of health providers in participating Aboriginal Medical Services. A control group will use their standard care practices. Smoking rates of the women cared for by health providers in each group will be compared.
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    Funded Activity

    Smoking Cessation And Bone Health: Observational And Intervention Studies In Twins And A Quitline Population

    Funder
    National Health and Medical Research Council
    Funding Amount
    $639,050.00
    Summary
    Osteoporosis is a major health problem that causes bones to break (fracture) easily. Many bones are susceptible, with hip fractures being the worst outcome of osteoporosis. They cause pain, disability, require major health interventions (surgery and rehabilitation), lead to death in about 20% of cases, and the overall care of hip fracture patients is very expensive. Osteoporosis is treated to reduce the risk of fractures. The prevention and treatment of osteoporosis should include avoidance of f .... Osteoporosis is a major health problem that causes bones to break (fracture) easily. Many bones are susceptible, with hip fractures being the worst outcome of osteoporosis. They cause pain, disability, require major health interventions (surgery and rehabilitation), lead to death in about 20% of cases, and the overall care of hip fracture patients is very expensive. Osteoporosis is treated to reduce the risk of fractures. The prevention and treatment of osteoporosis should include avoidance of factors known to bring on or worsen the condition. Smokers are known to have an increased risk of osteoporosis and fractures. However, it is not known how smoking brings on osteoporosis. Importantly, neither is it clear whether quitting smoking leads to improved bone health (and a reduced risk of fractures). These are important questions for the community in general and for smokers with osteoporosis in particular. We will endeavour to answer these questions by studying twins who do and do not smoke and by observing what happens to measures of bone health (bone mineral density and other factors) in people attempting to quit smoking. New information gained from these studies may lead to better ways of avoiding or treating the damage that smoking does to bone. We may also become able to predict the benefit to bone when people quit smoking.
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