Statistical Methods For Identifying Structural Variation In Tumour Genomes Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$243,458.00
Summary
New DNA sequencing technology can sequence a tumour genome affordably in 2 weeks. This re-sequencing data can be used to find small mutations and large-scale chromosomal rearrangements that together are the drivers of cancer. These may one day be used to guide cancer therapy. This project will develop new algorithms for finding mutations and apply these to discover the genetic basis of drug resistance in a model lymphoma system.
Clonal Evolution In Myelodysplasia And Acute Myeloid Leukaemia Following Azacitidine
Funder
National Health and Medical Research Council
Funding Amount
$853,005.00
Summary
The myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) represent a spectrum of clinically heterogeneous malignancies that remain incurable in the vast majority of patients. Whilst the DNA mutations underpinning the initiation/maintenance of these malignancies are largely known we have little insight into how these mutations alter response to therapy. Using a range of sophisticated cutting edge technologies we will study how these DNA mutations evolve over the course of treatment.
A Functional Assay To Classify Genetic Variants In Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$368,195.00
Summary
At least one person in every 1000 is affected by Lynch syndrome, in which faulty DNA repair machinery causes high rates of cancer. People with Lynch syndrome can have their risk of cancer cut substantially with regular screening. However, we often struggle to understand whether people with 'non-standard' DNA sequences in particular genes actually have Lynch syndrome. This project develops a simple test that will tell clinicians whether a given sequence change relates to Lynch syndrome or not.
Fighting Epidermal Skin Cancers By Targeting Epidermal Clones That Accumulate Mutations
Funder
National Health and Medical Research Council
Funding Amount
$1,149,373.00
Summary
Common skin cancers such as basal and squamous cell carcinomas (BCC and SCC) are by far the most frequent cancer worldwide and require over a million interventions per year in Australia. This project will identify the skin cells that are most susceptible to give rise to cancer if excessively exposed to the sun and explores ways to prevent cancer formation. This will inform on new strategies to prevent new skin cancer development.
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
A direct drive linear tube generator for ocean wave energy conversion. This project aims to investigate a direct drive linear electromagnetic generator system for the maximum wave energy conversion and frequency bandwidth. This system has a translator of a multiple degree of freedom non-linear oscillator system built with the Halbach ring array pattern and ferro-fluid bearings. To establish wave energy conversion science, this project will investigate the device, its integration with a buoy stru ....A direct drive linear tube generator for ocean wave energy conversion. This project aims to investigate a direct drive linear electromagnetic generator system for the maximum wave energy conversion and frequency bandwidth. This system has a translator of a multiple degree of freedom non-linear oscillator system built with the Halbach ring array pattern and ferro-fluid bearings. To establish wave energy conversion science, this project will investigate the device, its integration with a buoy structure under wave loadings and automatic control of power conversion and conditioning. The outcome could meet demands for wave energy conversion technologies that reduce power generation cost and emissions, benefiting the Australian economy and environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100135
Funder
Australian Research Council
Funding Amount
$438,400.00
Summary
Superhydrophobic thermally rearranged membranes for low-energy separation. This project aims to develop thermally rearranged membranes with superhydrophobicity using novel polymer chemistry and nanofibre morphology. Both water flowrate in membrane distillation and gas flowrate in carbon dioxide stripping from solvents will be increased by minimising the water vapor condensation between the nanofibers; resolving shortcomings in current energy-intensive filtration systems. This project will provid ....Superhydrophobic thermally rearranged membranes for low-energy separation. This project aims to develop thermally rearranged membranes with superhydrophobicity using novel polymer chemistry and nanofibre morphology. Both water flowrate in membrane distillation and gas flowrate in carbon dioxide stripping from solvents will be increased by minimising the water vapor condensation between the nanofibers; resolving shortcomings in current energy-intensive filtration systems. This project will provide significant benefits to Australian communities by advancing cost-effective and energy-efficient potable water production and carbon dioxide separation processes for sustainable development. The advanced materials developed can be manufactured locally and will enhance our national capability in modern manufacturing.Read moreRead less
New genomic technologies are revolutionizing biological research. RNA-seq is a recently developed high-throughput sequencing technology that provides scientists with much more detail how genes are regulated and expressed than any earlier technology. New tools developed by Professor Gordon Smyth are allowing researchers to use RNA-Seq technology to more accurately determine which genes are genuinely changing in the development of cancers and in response to cancer treatments.
Ambient Electrochemical C-N Coupling via Co-electrolysis of N2 and CO2. To overcome the hurdles in N2 fixation (massive energy consumption and CO2 emission), investigators creatively hypothesize that the simultaneous electrocatalytic coupling of N2 and CO2 would enable the selective formation of N-products and thus realize their conversion into N--fertilizers and acetamides. Based on the CI's recent discoveries, this project will develop an innovative / sustainable system, which could promote th ....Ambient Electrochemical C-N Coupling via Co-electrolysis of N2 and CO2. To overcome the hurdles in N2 fixation (massive energy consumption and CO2 emission), investigators creatively hypothesize that the simultaneous electrocatalytic coupling of N2 and CO2 would enable the selective formation of N-products and thus realize their conversion into N--fertilizers and acetamides. Based on the CI's recent discoveries, this project will develop an innovative / sustainable system, which could promote the N2 fixation along with CO2 conversion process, a significant alternative approach to simplify the pathways of C-N bond formation. It will thereby contribute to mitigation of greenhouse emissions and create an ecofriendly protocol/technology for distributed production of C-N products under ambient conditions. Read moreRead less
Geological sequestration of carbon dioxide in deep saline aquifers: coupled flow-mechanical considerations. Deep saline aquifers have been routinely proposed as sites for long-term, large-scale storage of carbon dioxide (CO2) emissions, as an option to assist the abatement of global warming. This project investigates expected engineering behaviour of deep saline aquifer reservoirs and their stability following CO2 sequestration.