Identifying Resistance Mechanisms Of Targeted BRAF Inhibitors In Metastatic Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$379,015.00
Summary
Late-stage melanoma is an aggressive skin cancer for which traditional treatment strategies such as chemotherapy are ineffective. Recently, a new class of targeted drugs (BRAF inhibitors) has become the standard of care for a subset of melanoma patients; however, long term treatment success is complicated by drug resistance. This study will identify the causes of resistance with the purpose to improve targeted drug strategies and increase survival rates for late-stage melanoma patients.
Improving Oesophageal Adenocarcinoma Outcomes Through Understanding Genomics And Treatment Toxicity.
Funder
National Health and Medical Research Council
Funding Amount
$1,013,282.00
Summary
Oesophageal adenocarcinoma is an aggressive cancer, as most patients will not survive for more than 5 years. Therefore we need to find better ways to treat patients. In this study we will identify the DNA mutations in oesophageal cancers that were part of clinical trial. The data allow us to determine why some tumours responded well to therapy, and why some patients had serious side effects to the treatment. The results will help inform on selection of therapy for future patients.
Identifying Mitochondrial Genome Variants Associated With Familial Migraine Susceptibility
Funder
National Health and Medical Research Council
Funding Amount
$443,273.00
Summary
New therapeutic targets for migraine are desperately needed. Although studies have identified some migraine genes there remains considerable underlying genetic variation to be characterised. This study aims to identify functional variants in the mitochondrial genome that contribute to migraine susceptibility, utilising the isolated Norfolk Island population. Outcomes will determine the significance of the variants identified, potentially leading to new diagnostics.
Identifying Novel Gene Mutations For Molecular Diagnosis Of Familial Hemiplegic Migraine
Funder
National Health and Medical Research Council
Funding Amount
$623,460.00
Summary
This proposal aims to identify novel FHM genes by undertaking an NGS screen of the whole exome of 209 FHM patient samples. We will test the pathological relevance of detected novel mutations by functional analysis in human cell models and using patient-specific stem cell techniques. Using whole genome NGS technology to identify novel mutations will assist in the design and development of a comprehensive NGS approach to diagnose and differentiate this severe neurological disorder.
Fighting Epidermal Skin Cancers By Targeting Epidermal Clones That Accumulate Mutations
Funder
National Health and Medical Research Council
Funding Amount
$1,149,373.00
Summary
Common skin cancers such as basal and squamous cell carcinomas (BCC and SCC) are by far the most frequent cancer worldwide and require over a million interventions per year in Australia. This project will identify the skin cells that are most susceptible to give rise to cancer if excessively exposed to the sun and explores ways to prevent cancer formation. This will inform on new strategies to prevent new skin cancer development.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100205
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A novel high-pressure system for multiple gas adsorption. This facility will equip researchers with analytical capabilities for research in the field of multi-gas adsorption. The facility will be of great significance to clean energy research, such as greenhouse gas emission control and hydrogen production and storage.
Structural modelling of silicon carbide-derived microporous carbon and its application in carbon dioxide capture from moist gases. The project will deliver a powerful new tool for determining the nanostructure of carbons, and will advance the modelling of fluid equilibrium, accessibility and transport within this structure. The outcomes will be crucial to the development of emerging technologies in nanofluidics, gas and electrochemical energy storage, and gas separation.
Electrochemical conversion of carbon dioxide to formic acid. This project aims to develop economical and scalable carbon dioxide electrochemical technologies to convert carbon dioxide in blast furnace flue gas to formic acid as a value-added product in steel-making plants. The project expects to develop new electrochemical catalysts, to optimise the structure of electrodes and ultimately improve carbon dioxide conversion efficiency and reaction selectivity towards formic acid. The expected outco ....Electrochemical conversion of carbon dioxide to formic acid. This project aims to develop economical and scalable carbon dioxide electrochemical technologies to convert carbon dioxide in blast furnace flue gas to formic acid as a value-added product in steel-making plants. The project expects to develop new electrochemical catalysts, to optimise the structure of electrodes and ultimately improve carbon dioxide conversion efficiency and reaction selectivity towards formic acid. The expected outcomes of this project will provide an efficient and economically viable electrochemical technology to convert carbon dioxide to a valuable product such as formic acid or syngas, with the potential to significantly reduce the emission of carbon dioxide from steel-making processes and coal-fired power plants.Read moreRead less
Wearable thermoelectrics for personal heat management. Thermoregulation has substantial implications for energy consumption and human comfort and health. This project aims to develop wearable thermoelectric materials and devices with high cooling performance for personal heat management. A novel assembly approach, coupled with device design and materials engineering strategies, will be developed to engineer flexible thermoelectric materials with unique structures and chemistry. The key breakthro ....Wearable thermoelectrics for personal heat management. Thermoregulation has substantial implications for energy consumption and human comfort and health. This project aims to develop wearable thermoelectric materials and devices with high cooling performance for personal heat management. A novel assembly approach, coupled with device design and materials engineering strategies, will be developed to engineer flexible thermoelectric materials with unique structures and chemistry. The key breakthrough is to design wearable thermoelectric devices with high flexibility and user comfort. The expected outcomes of this project will lead to an innovative cooling technology for personal heat management, which will place Australia at the forefront of wearable electronics and garment industry.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100005
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub in Zero-emission Power Generation for Carbon Neutrality. This Hub aims to develop sustainable zero-emission power generation technologies to transform gaseous waste (mainly CO2) from our energy and manufacturing sectors into valuable products and create scalable pathways to market for driving industry transformation. This Hub expects to harvest renewable energy from the environment by using zero-emission power generators and then store it in green and safer batteries for convert ....ARC Research Hub in Zero-emission Power Generation for Carbon Neutrality. This Hub aims to develop sustainable zero-emission power generation technologies to transform gaseous waste (mainly CO2) from our energy and manufacturing sectors into valuable products and create scalable pathways to market for driving industry transformation. This Hub expects to harvest renewable energy from the environment by using zero-emission power generators and then store it in green and safer batteries for converting gaseous waste from sectors that cannot easily avoid emission into useful chemicals, which in turn realize carbon neutrality and negativity. The outcomes of this Hub are likely to be transformative for industry, the economy, and society in new-type renewable energy resources through decreasing environmental pollutants. Read moreRead less