Targeted Nanoparticles To Deliver Combinations Of Calcium Channel Inhibitors To Prevent Myelin Damage During Secondary Degeneration After Neurotrauma
Funder
National Health and Medical Research Council
Funding Amount
$895,244.00
Summary
Following injury to the central nervous system the damage spreads into nearby areas, leading to worse outcomes for the patient. We will generate nanoparticle systems to deliver effective therapies directly to the most vulnerable cells, critical for function. We will modify the nanoparticles so that they can get to the injury site, both early after injury, and after longer periods of time have elapsed. We will then test the nanoparticle systems to see if they are effective at preserving function
Innovative And Multi-disciplinary Treatment Strategies For Secondary Degeneration Following Neurotrauma
Funder
National Health and Medical Research Council
Funding Amount
$455,452.00
Summary
Following injury to the central nervous system the damage spreads into nearby areas, leading to worse outcomes for the patient. The research conducted during this Fellowship will ensure that promising treatment strategies to prevent spreading damage are used in the best way, and will determine the mechanism of action of these treatments.
Multimodal Electrically Conducting Bionic Implant For Long-distance Oriented Axonal Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Neurotrauma, defined as an injury to the central nervous system, is a debilitating medical condition affecting over 3 million people annually worldwide. Loss of function following injury is largely due to the limited potential of nerve cells to regenerate. I will develop a bionic platform that conducts electrical signals and delivers growth promoting proteins thereby enhancing the directed regeneration of nerve cells necessary to bridge the gap caused by the injury and restore organ function.
This proposal seeks to develop a novel non-invasive method of measuring intra-cranial pressure, an important diagnostic parameter in many form of brain injury or neural disease. It works by quantitative video analysis of the pulsation of the major vein in the eye during induced rises in eye pressure. Many years of study by our group have determined the relationship between vein pulsation pressure and intra-cranial pressure, and this information is used to produce an accurate measurement of intra ....This proposal seeks to develop a novel non-invasive method of measuring intra-cranial pressure, an important diagnostic parameter in many form of brain injury or neural disease. It works by quantitative video analysis of the pulsation of the major vein in the eye during induced rises in eye pressure. Many years of study by our group have determined the relationship between vein pulsation pressure and intra-cranial pressure, and this information is used to produce an accurate measurement of intra-cranial pressure without the need for surgery.Read moreRead less
Monitoring Cortical Excitability Using A Probing Stimulus For Epileptic Seizure Anticipation
Funder
National Health and Medical Research Council
Funding Amount
$392,997.00
Summary
Millions of people with epilepsy suffer from seizures that cannot be controlled by medication. Life-threatening seizure may strike at any time, restricting patients from leaving their homes due the constant fear of a seizure. This research offers hope for people with epilepsy by developing a method of anticipating seizures. Successful outcomes will not only provide a warning of impending seizures, but also an opportunity for intervention, thereby preventing seizures.
Elucidating The Neuroprotective Region Of The Amyloid Precursor Protein (APP) Following Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$467,556.00
Summary
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and to date there is no therapy to ameliorate this injury. There is increased production of the amyloid precursor protein (APP) following TBI and recent studies have found that APP possesses neuroprotective traits. It is the aim of the current studies to delineate the specific active neuroprotective region of APP and develop them as novel therapeutic interventions for use in TBI.