Investigation Of The Function Of The Scaffolding Protein LIN-2/CASK In Cholinergic Synapses
Funder
National Health and Medical Research Council
Funding Amount
$911,656.00
Summary
Scaffolding proteins play vital role in synapses to maintain the function of the nervous system. One important scaffolds LIN-2/CASK has been implicated in autism disorders and has profound effect on synaptic function. Here we investigate the function of LIN-2/CASK and its binding partners in cholinergic synapses to dissect how they regulate synaptic transmission.
Structural Studies On Human Glutamic Acid Decarboxylase
Funder
National Health and Medical Research Council
Funding Amount
$380,902.00
Summary
Mental health problems are a global issue and are subject to ongoing medical research. We study glutamic acid decarboxylase, a key enzyme responsible for the synthesis of a prominent and abundant neurotransmitter called GABA. GABA is crucial in controlling neuronal responses and facilitating new interconnections between neurones. Lacking GABA is related to epilepsy, Parkinson's disease, and post-traumatic stress. Our study is important for development of new ways to improve the supply of GABA in ....Mental health problems are a global issue and are subject to ongoing medical research. We study glutamic acid decarboxylase, a key enzyme responsible for the synthesis of a prominent and abundant neurotransmitter called GABA. GABA is crucial in controlling neuronal responses and facilitating new interconnections between neurones. Lacking GABA is related to epilepsy, Parkinson's disease, and post-traumatic stress. Our study is important for development of new ways to improve the supply of GABA in the brain.Read moreRead less