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Development of integrated biological markers of brain function. With the rapid growth of both brain imaging and genetics, we can now examine the biological basis of complex brain functions, such as memory. Our goal is to combine these techniques to develop evidence-based biological markers of normal function. These markers can then be used to screen for early signs of abnormal function (eg. in Alzheimer's disease) and to assess treatment effects. Two unique features ensure the project's feasibil ....Development of integrated biological markers of brain function. With the rapid growth of both brain imaging and genetics, we can now examine the biological basis of complex brain functions, such as memory. Our goal is to combine these techniques to develop evidence-based biological markers of normal function. These markers can then be used to screen for early signs of abnormal function (eg. in Alzheimer's disease) and to assess treatment effects. Two unique features ensure the project's feasibility: a) access to the first standardized, normative brain database (from the Brain Resource Company Ltd) and b) a scientific collaboration supporting the integration of brain imaging and genetics.Read moreRead less
Are neurobehavioural and neuromotor impairments associated with FMR1 gene expansion? The gene that causes Fragile X syndrome is found at the end of the X chromosome and is present in all humans. In many cases there is a small to medium change in this gene that may cause psychological and motor difficulties in later adulthood. The core aim of this project is to identify early age-related changes that would indicate later neurological decline.
Identification of genetic polymorphisms of synaptically expressed genes that contribute to variation in normal brain function. This project focuses on understanding brain functions. Brain and mind disorders are by far the largest contributors to the burden of disability, far exceeding any other disorder. This research will contribute to knowledge through addressing the national research priority promoting and maintaining good health. The research outcomes will form the scientific knowledge base ....Identification of genetic polymorphisms of synaptically expressed genes that contribute to variation in normal brain function. This project focuses on understanding brain functions. Brain and mind disorders are by far the largest contributors to the burden of disability, far exceeding any other disorder. This research will contribute to knowledge through addressing the national research priority promoting and maintaining good health. The research outcomes will form the scientific knowledge base essential for the translation of the project into public benefit through their application in development of new testing paradigms for a range of brain and mind disorders. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101102
Funder
Australian Research Council
Funding Amount
$378,536.00
Summary
Memory Engram Storage and Retrieval. This project aims to probe how long-term memory is stored in the brain. Recently, memory engram-labelling technology has revolutionised the way memory can be experimentally studied. It is now known that sparse populations of neurons that were active during a defined training window are both sufficient and necessary for retrieval of specific memories, and that activation of hippocampal engram causes further downstream activity in connected engram cells of othe ....Memory Engram Storage and Retrieval. This project aims to probe how long-term memory is stored in the brain. Recently, memory engram-labelling technology has revolutionised the way memory can be experimentally studied. It is now known that sparse populations of neurons that were active during a defined training window are both sufficient and necessary for retrieval of specific memories, and that activation of hippocampal engram causes further downstream activity in connected engram cells of other brain regions. However, it is unknown whether engram cell connectivity is important for memory function. The project aims to test this question. Understanding more about memory function in normal conditions may help us to understand and treat disorders of memory.Read moreRead less
The genetic basis of human memory. This project will examine the relationship between genetic variation and performance of normal individuals on a comprehensive range of memory test indicators. Results of the study will clarify the genetic basis of human memory and provide a better understanding of this important function.
The articulate brain. Language is essential to human interaction, yet we know comparatively little about the mental processes involved and how they are represented in the brain, how genetic and environmental factors contribute to the development of language, or how effective treatments of language disorders work. The significance of this program of research lies in its capacity to enhance our understanding of a range of mechanisms responsible for a fundamentally human ability, and provide inform ....The articulate brain. Language is essential to human interaction, yet we know comparatively little about the mental processes involved and how they are represented in the brain, how genetic and environmental factors contribute to the development of language, or how effective treatments of language disorders work. The significance of this program of research lies in its capacity to enhance our understanding of a range of mechanisms responsible for a fundamentally human ability, and provide information that will ultimately inform clinical practice. In particular, new knowledge about the brain mechanisms involved in language processing and recovery will inform clinicians about the optimal choice of treatment to maximise outcomes for the individual patient. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100088
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Central nervous system insulin and hippocampal-dependent cognitive function. This project plans to examine the effects of both infusion of insulin into the brain and the genetic knockdown of insulin transport and activity on cognitive function in mice. This project should increase our understanding of how circulating insulin enters the brain to influence the brain and resulting behaviours.