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Obstructive Sleep Apnea affects 800,000 Australians and cost the country billions of dollars per year. Immediate daytime consequences of OSA are neurocognitive impairments leading to 200-700% increase in accident risks and a low quality of life. Longer-term consequences include high risk for diabetes and heart disease. There are no simple tests for assessing neurocognitive impairment in OSA. The project develops an automated test to administer neurocognitive functions.
Social Functioning And Autism Spectrum Disorder In Children With Neurofibromatosis Type 1: A Multimodal Study.
Funder
National Health and Medical Research Council
Funding Amount
$107,204.00
Summary
Social difficulties and symptoms of autism spectrum disorder (ASD) are frequently found in children with neurofibromatosis type 1 (NF1), a common genetic condition. The current study will examine (1) prevalence and characteristics of ASD and social impairment in children with NF1, (2) cognitive factors contributing to ASD symptoms and (3) associated compromise to brain structure. Findings are expected to guide development of treatments to improve social functioning in children with NF1.
Organic Brain Damage After Non-fatal Opioid Overdose
Funder
National Health and Medical Research Council
Funding Amount
$244,858.00
Summary
The study will provide the first data on the level and nature of brain damage due to opioid overdose. The extent to which overdose survivors suffer brain damage has important implications for clinical management, particularly in relation to behavioural problems. It will also provide the first data on brain damage and drug treatment performance. Screening of those with an overdose history may lead to specialised management of these individuals with the potential for improved treatment outcome.
Do People With Severe Traumatic Brain Injury Benefit From Making Errors? A Clinical Trial Of The Efficacy Of Error-based Learning And Errorless Learning Training
Funder
National Health and Medical Research Council
Funding Amount
$579,142.00
Summary
People with severe traumatic brain injury (TBI) have trouble recognising changes in their abilities and often fail to notice mistakes on daily tasks. Although people can learn strategies, these are rarely used as needed in daily life. This study will determine whether people with severe TBI become more self-aware and able to transfer what they learn when they are made aware of their errors, as compared to when other people prevent them from making errors. The findings will have major implication ....People with severe traumatic brain injury (TBI) have trouble recognising changes in their abilities and often fail to notice mistakes on daily tasks. Although people can learn strategies, these are rarely used as needed in daily life. This study will determine whether people with severe TBI become more self-aware and able to transfer what they learn when they are made aware of their errors, as compared to when other people prevent them from making errors. The findings will have major implications for rehabilitation of neurological disorders.Read moreRead less
Obstructive sleep apnea (OSA) is increasing in prevalence due to the ageing and increasing overweight and obesity of populations worldwide. This Fellowship will 1. Find new, cost-effective strategies to prevent and diagnose OSA; 2. Lead to a deeper understanding of the cardiovascular and neuro-behavioural consequences of OSA and the likely benefits of OSA treatment; and 3. Discover more effective and cost-effective therapies that are targeted toward a patient’s specific type of OSA.
Improving Clinical Diagnosis Of Mild Neurocogntive Disorders Using Neuropsychological Assessment
Funder
National Health and Medical Research Council
Funding Amount
$155,932.00
Summary
A major proportion of neuropsychiatric disability in old age is due to dementia or milder cognitive disorders. However, these disorders can be challenging to diagnose because of the subtlety of cognitive deficits and a lack of appropriate normative reference groups. By developing comprehensive, representative Australian normative data for key diagnostic measures and refining clinical diagnostic methods, the study will have a major impact on the accuracy of neuropsychological assessment practice.
Enhancing Treatment Effectiveness For Psychosocial Disorders After Severe Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$253,750.00
Summary
Motor vehicle accidents are a major cause of severe traumatic brain injury (TBI) leading to lifelong, crippling disability. In NSW alone, there are approximately 770 new cases of severe brain injury each year. These people require extensive inpatient rehabilitation and many go on to rely upon community resources for the rest of their lives. The social and economic cost of such injury is cumulative. TBI is mainly experienced by young adults (18-24 years of age) who have normal life expectancy and ....Motor vehicle accidents are a major cause of severe traumatic brain injury (TBI) leading to lifelong, crippling disability. In NSW alone, there are approximately 770 new cases of severe brain injury each year. These people require extensive inpatient rehabilitation and many go on to rely upon community resources for the rest of their lives. The social and economic cost of such injury is cumulative. TBI is mainly experienced by young adults (18-24 years of age) who have normal life expectancy and each year more casualties are added to this social burden. Adults with TBI frequently experience a reduction in social skills. Loss of social skills presents major obstacles to reintegration into the community by making the sufferer more taxing and less rewarding to interact with socially. This loss of social skills limits their ability to maintain pre-injury relationships, and often creates an off-putting first impression on potential new acquaintances that interferes with their ability to establish new relationships. The following project is designed to develop and evaluate a treatment program to enhance the TBI individual's ability to create a good first impression on meeting new acquaintances - e.g., potential employers, work colleagues, customers, and social acquaintances - and to engage in behaviour that is mutually rewarding. The project will inform current theoretical approaches to remediation, providing an examination of the modifiability of social skills deficits that are the result of underlying cognitive impairments. It will provide a systematic, integrated social skills treatment approach for both individuals and groups where there are currently very few. The identification and refinement of successful treatment techniques will increase the efficiency of brain injury rehabilitation in Australia, improve the quality of life for sufferers of TBI and their families, reduce cost of rehabilitation and reduce reliance upon community resources in the long term.Read moreRead less
A Clinical Trial Of The Effect Of Neuropsychological Treatments In Increasing Community Participation After Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$365,700.00
Summary
Traumatic brain injury is very common, with more than 2,000 people surviving serious brain injury in NSW each year. The survivors are most commonly young adult males and many are left with permanent brain damage, invariably affecting cognitive abilities. The impact of cognitive impairments on the person's capacity to resume their premorbid lifestyle is enormous. In one of our studies we found that 40% did not work but nor did they have any meaningful occupational activity to replace work. The cu ....Traumatic brain injury is very common, with more than 2,000 people surviving serious brain injury in NSW each year. The survivors are most commonly young adult males and many are left with permanent brain damage, invariably affecting cognitive abilities. The impact of cognitive impairments on the person's capacity to resume their premorbid lifestyle is enormous. In one of our studies we found that 40% did not work but nor did they have any meaningful occupational activity to replace work. The current project targets this large group of people in particular. The study aims to develop and test two alternative, intensive cognitive treatment programs that are geared to increasing community participation, everyday activities and psychological well-being. To date, no such therapies have been evaluated using powerful methodological designs. As a result of the study we will be able to incorporate the standardised interventions into a format that can be easily applied to Brain Injury Rehabilitation Services in Australia. The programs will not only improve the functioning of the individuals with brain injury, but will have a flow-on effect for their families and the community at large.Read moreRead less
Optimum Thiamine Dose For Treatment And Prevention Of Wernicke-Korsakoff Syndrome (WKS): A Randomised Controlled Trial Targeting Aboriginal People.
Funder
National Health and Medical Research Council
Funding Amount
$1,293,716.00
Summary
Wernicke-Korsakoff syndrome (WKS), once thought to be a rare condition, is now known to be common in people with nutritional deficiencies or alcohol dependence. WKS may lead to significant, long-term brain dysfunction with severe effects on work, personal and social function. Whilst effective treatment may greatly reduce severe disability and the human and social costs of this illness, almost no evidence exists on optimal dosing regimens. This project proposes to develop quality evidence for eff ....Wernicke-Korsakoff syndrome (WKS), once thought to be a rare condition, is now known to be common in people with nutritional deficiencies or alcohol dependence. WKS may lead to significant, long-term brain dysfunction with severe effects on work, personal and social function. Whilst effective treatment may greatly reduce severe disability and the human and social costs of this illness, almost no evidence exists on optimal dosing regimens. This project proposes to develop quality evidence for effective treatment of WKS in an Aboriginal setting.Read moreRead less
Clinical And Biological Markers Of Disease Presentation And Progression In Early Frontotemporal Dementia
Funder
National Health and Medical Research Council
Funding Amount
$507,636.00
Summary
Frontotemporal dementia accounts for 12-20% of all dementia cases and is as common as Alzheimer's disease in the < 65 year olds. Our understanding of this disease remains limited. This project aims to better characterise the range and progression of deficits in early frontotemporal dementia using tests of brain function and magnetic resonance imaging. This will assist in better diagnosis of these patients and, ultimately, may be used to monitor the outcomes of therapeutic interventions.