Uncovering Oxytocin And Vasopressin Release And Functions With Novel Optical Tools
Funder
National Health and Medical Research Council
Funding Amount
$631,634.00
Summary
Oytocin and vasopressin are peptides in the brain that act as releasable neuromodulators and the balance of these peptides is implicated in the control of social behaviour and anxiety. We aim to investigate the release and function of these neuropeptides with 3 novel protein-based tools in a stressful learning paradigm and anxious behaviour. The understanding of their function will have important implications in the development of therapeutics for neurological conditions and drug addictions.
Cortical Neuroprosthesis To Restore Visual Perception To Bling Patients.
Funder
National Health and Medical Research Council
Funding Amount
$189,250.00
Summary
We will develop a medical device to restore visual perception to profoundly blind patients. This device will act to electrically stimulate the visual area of the brain. Electrical stimulation of this area leads to the visual perception of small spots of light in patients who are otherwise blind. By correlating the stimulation of the brain, which leads to the perception of spots of light, with an image of the surrounding environment acquired by a camera and digitally enhanced, we aim to provide b ....We will develop a medical device to restore visual perception to profoundly blind patients. This device will act to electrically stimulate the visual area of the brain. Electrical stimulation of this area leads to the visual perception of small spots of light in patients who are otherwise blind. By correlating the stimulation of the brain, which leads to the perception of spots of light, with an image of the surrounding environment acquired by a camera and digitally enhanced, we aim to provide blind patients with a very basic visual perception of their surroundings.Read moreRead less
Identifying Novel Markers To Differentiate Frontotemporal Dementia From Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$603,912.00
Summary
In people under 65 years of age, frontotemporal dementia and Alzheimer's disease are equally common. Distinguishing between these different types of dementia is extremely challenging. Patients can present with similar symptoms, even when the underlying dementia cause (i.e., brain pathology) is different. Inaccurate diagnosis means patients cannot access appropriate treatments, as these become available. I will develop novel tests of social function to improve the diagnosis of dementia syndromes.
Understanding Cortical Circuitry Underlying Sensory Integration And The Consequence Of Its Developmental Disruption
Funder
National Health and Medical Research Council
Funding Amount
$527,395.00
Summary
The mammalian neocortex is organised into six layers with a systematic pattern of wiring that relies on normal development and balanced activity of neurons. This project combines developmental, electrophysiological, optogenetic behavioural, and computational methods to establish how the properties of the precise structure of cortical circuits impact their function and how disruptions in the balanced activity during development affect circuit formation and function in the mature brain.
Integrative Properites Of Intrinsic Sensory Neurons Of The Intestine
Funder
National Health and Medical Research Council
Funding Amount
$211,681.00
Summary
For the neuronal control of the intestine to be appropriate to the constantly changing state of the organ, it is essential that there is feedback concerning, amongst other things, distension by its contents and its contractile state. These properties of the intestine are monitored by intrinsic sensory neurons, which are very special sensory cells, because they are embedded in the wall of the organ that they control. They have only very recently been identified, and thus surprisingly little is kn ....For the neuronal control of the intestine to be appropriate to the constantly changing state of the organ, it is essential that there is feedback concerning, amongst other things, distension by its contents and its contractile state. These properties of the intestine are monitored by intrinsic sensory neurons, which are very special sensory cells, because they are embedded in the wall of the organ that they control. They have only very recently been identified, and thus surprisingly little is known about how they perform their functions. It is clear, however, that they have special ways of integrating information about their environment, and the activities of other neurons, that are not shared by any other sensory neurons identified to the present time. Thus investigation of these neurons will provide information that is almost completely lacking about how the intestine performs its tasks. This information will be valuable in defining targets for development of therapeutic compounds and in analysing disorders of intestinal motility.Read moreRead less
Reconceptualising Neurophysiological Biomarkers Of Schizophrenia: An Investigation Of The MMN/P3a Complex In Early Psychotic Disorders
Funder
National Health and Medical Research Council
Funding Amount
$46,733.00
Summary
I am measuring a brain response to subtle changes in the environment called �mismatch negativity�. MMN indexes fundamental sensory processes that help the brain focus on certain information and ignore other information. MMN is consistently impaired in patients with Schizophrenia and is thought to be a biomarker of this illness. I am assessing MMN in the very early stages of psychosis to determine its specificity and whether it predicts illness trajectory.
Nerve And Muscle Excitability In Inclusion Body Myositis
Funder
National Health and Medical Research Council
Funding Amount
$81,294.00
Summary
Our study will use recently developed neurophysiological techniques to study nerve and muscle excitability in sporadic inclusion body myositis, a poorly understood progressive muscle disease for which no effective treatment is known. We will determine whether the electrical properties of nerve and muscle cell membranes are affected and obtain clues as to where this dysfunction may occur. This may aid development of effective therapies through a better understanding of disease mechanisms.