RESTORING COGNITIVE FUNCTION USING BRAIN STIMULATION: Investigating The Neurobiological And Neurocognitive Effects Of Non-invasive Brain Stimulation In Schizophrenia.
Funder
National Health and Medical Research Council
Funding Amount
$426,556.00
Summary
Cognitive impairments are a core feature of schizophrenia and can have devastating impacts on daily functioning. Despite this, treatment options are few and of limited effectiveness. Recent research, including my own work, has indicated that brain stimulation has considerable potential in this regard. In this fellowship I will develop a treatment approach which will utilise brain stimulation to target and modify the underlying neurobiology of the cognitive symptoms in schizophrenia.
Cellular Mechanisms Underlying Neurodegenerative Disease And The Neuronal Response To Trauma
Funder
National Health and Medical Research Council
Funding Amount
$406,264.00
Summary
Brain and spinal cord injury are major causes of death and disability, with degenerative diseases similarly affecting large proportions of the population. The singular objective of my research proposal is to increase our understanding of the molecular and cellular processes by which nerve cells respond to trauma and diseases such as Alzheimer’s and Parkinson’s, and to identify new therapeutic approaches aimed at encouraging the repair of damaged cells.
The Function And Modulation Of Dendritic Activity Underlying Neural Circuits And Behavior
Funder
National Health and Medical Research Council
Funding Amount
$450,641.00
Summary
Understanding how brain cells translate sensory input into behaviour is central to explaining how the brain works. My research focuses on the long-standing question of how information from different brain regions is received and processed within individual brain cells. This research is crucial to understanding brain function and can provide a greater understanding of the neuronal processes underlying diseases such as epilepsy, schizophrenia, depression and alcoholism.
Modifiable Risks And Interventions For Cognitive Decline, Depression And Dementia In Older People
Funder
National Health and Medical Research Council
Funding Amount
$430,055.00
Summary
This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors pr ....This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors promote neuroplasticity.Read moreRead less
This research will elucidate pathways in the brain that control satiety, in particular the role of neuropeptide Y and the satiety hormones peptide YY and pancreatic polypeptide. By understanding how satiety is controlled, this process could be stimulated for potential use as a novel treatment strategy for obesity or anorexia.
Neurorestorative Rehabilitation In Children With Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
Cerebral palsy (CP) is the most common physical disability (1 in 500) with life-long impact. The economic burden is AUS$1.47 billion/yr. Children have limitations in function which impacts daily activities and participation. Deficits in visual perception and learning have an impact on vocational aspirations. This program will test novel interventions (Action Observation training, constraint induced movement therapy, multi-modal web training) measuring broad outcomes and mechanisms with Advanced ....Cerebral palsy (CP) is the most common physical disability (1 in 500) with life-long impact. The economic burden is AUS$1.47 billion/yr. Children have limitations in function which impacts daily activities and participation. Deficits in visual perception and learning have an impact on vocational aspirations. This program will test novel interventions (Action Observation training, constraint induced movement therapy, multi-modal web training) measuring broad outcomes and mechanisms with Advanced Brain Imaging.Read moreRead less