Axonal Regeneration And Degeneration: Cellular And Molecular Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$2,088,220.00
Summary
The ability to surgically repair an injured axon and restore neuronal function is still a significant challenge in neurosurgery. However, a spontaneous repair mechanism, axonal fusion, by which the two separated ends of a transected axon are fused back together, has been observed in invertebrates. Understanding the molecular mechanisms of this biological event will allow us to determine its potential as a novel therapeutic approach to repair injured and damaged neurons.
Shallow water carbonate sediment dissolution in the global carbon cycle. Carbonate sediment dissolution is a globally significant process, but poorly understood in shallow marine waters. This project will determine whether the combined effect of organic matter, ocean acidification and pore water flow in shallow water carbonate sediments increases the release of calcium and alkalinity to the ocean. This project is significant because this release has not previously been accounted for and may lead ....Shallow water carbonate sediment dissolution in the global carbon cycle. Carbonate sediment dissolution is a globally significant process, but poorly understood in shallow marine waters. This project will determine whether the combined effect of organic matter, ocean acidification and pore water flow in shallow water carbonate sediments increases the release of calcium and alkalinity to the ocean. This project is significant because this release has not previously been accounted for and may lead to an additional uptake of atmospheric carbon dioxide into the global ocean, maybe some additional buffering against ocean acidification, but unfortunately, maybe also a loss of carbonate ecosystems. The outcomes of this project will make a significant contribution to our understanding of the global carbon cycle.
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Can eco-evolutionary theories explain outcomes of microbiome coalescence . Environmental microbial communities are among the most abundant and diverse natural communities, responsible for many ecologically and economically important ecosystem functions, including primary productivity and climate regulation. This project aims to identify the biotic and abiotic factors that regulate community and functional outcomes of microbiome coalescence (the mixing of two different communities) caused by natu ....Can eco-evolutionary theories explain outcomes of microbiome coalescence . Environmental microbial communities are among the most abundant and diverse natural communities, responsible for many ecologically and economically important ecosystem functions, including primary productivity and climate regulation. This project aims to identify the biotic and abiotic factors that regulate community and functional outcomes of microbiome coalescence (the mixing of two different communities) caused by natural and anthropogenic activities. The outcomes will provide a unifying ecological framework to predict variation in microbiomes across different scales, ecosystem types and disturbances, and will generate critical knowledge for the development of effective microbiome products, a rapidly growing industryRead moreRead less
Tree-mediated methane fluxes: A new frontier in the global carbon cycle. Methane is an extremely potent greenhouse gas. Recent evidence suggests that tree-mediated fluxes may be a significant, but overlooked source of methane to the atmosphere. This project aims to quantify the magnitude and drivers of tree-mediated methane fluxes from Australia’s dominant forest types. Innovatively, we will be using a novel combination of empirical field based measurements, gas tracer experiments, microbial ana ....Tree-mediated methane fluxes: A new frontier in the global carbon cycle. Methane is an extremely potent greenhouse gas. Recent evidence suggests that tree-mediated fluxes may be a significant, but overlooked source of methane to the atmosphere. This project aims to quantify the magnitude and drivers of tree-mediated methane fluxes from Australia’s dominant forest types. Innovatively, we will be using a novel combination of empirical field based measurements, gas tracer experiments, microbial analysis and modelling methods. Expected outcomes are a mechanistic understanding of tree-mediated methane fluxes, helping to constrain regional, national and global methane budgets. The results of this study will help inform publicly funded greenhouse gas abatement strategies, ensuring a maximal return on investment.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL190100062
Funder
Australian Research Council
Funding Amount
$3,130,000.00
Summary
A new functional approach to coral reefs. This project aims to identify the key ecosystem functions that are needed to sustain coral reefs and determine their susceptibility to disturbance. Around the world coral reefs are changing fast, challenging traditional scientific, management, and governance approaches. This project plans to address this challenge by implementing a new, functional, approach exploiting a unique combination of evolutionary and ecological methodologies. Expected outcomes in ....A new functional approach to coral reefs. This project aims to identify the key ecosystem functions that are needed to sustain coral reefs and determine their susceptibility to disturbance. Around the world coral reefs are changing fast, challenging traditional scientific, management, and governance approaches. This project plans to address this challenge by implementing a new, functional, approach exploiting a unique combination of evolutionary and ecological methodologies. Expected outcomes include a global overview of ecosystem function and an in-depth understanding of how ecosystems change over time. This is likely to result in specific, and practical, management objectives by identifying crucial ecosystem functions that support reefs and the people who rely on them. Read moreRead less
Predicting biodiversity distribution on the Antarctic continental shelf. This project aims to develop an international database of underwater observations to predict the distribution of seafloor biodiversity over the entire Antarctic continental shelf for the present day and to 2100. Antarctic seafloor communities are unique and highly diverse, but their distribution is poorly known because biological data are sparse. These predictions depend on a unique and validated approach to estimate the pr ....Predicting biodiversity distribution on the Antarctic continental shelf. This project aims to develop an international database of underwater observations to predict the distribution of seafloor biodiversity over the entire Antarctic continental shelf for the present day and to 2100. Antarctic seafloor communities are unique and highly diverse, but their distribution is poorly known because biological data are sparse. These predictions depend on a unique and validated approach to estimate the present and future redistribution of surface primary production to the seafloor, and will enable calculating the amount of atmospheric carbon captured and stored at the seafloor. The maps will be at an unprecedented resolution of around 2 kilometres, and be invaluable tools underpinning policy, management and future science.Read moreRead less
A Universal Power Law for Growth and Diversity of Dinosaur and Bird Beaks. Universal rules that govern how animals grow have tremendous power to explain the highly complex processes of growth and development. The project investigators have recently discovered a new rule of growth that controls how teeth, horns, claws and beaks are generated in animals. This project aims to use this new rule to examine the evolution and diversity of beaks in birds and dinosaurs. By combining 3D modelling, biomech ....A Universal Power Law for Growth and Diversity of Dinosaur and Bird Beaks. Universal rules that govern how animals grow have tremendous power to explain the highly complex processes of growth and development. The project investigators have recently discovered a new rule of growth that controls how teeth, horns, claws and beaks are generated in animals. This project aims to use this new rule to examine the evolution and diversity of beaks in birds and dinosaurs. By combining 3D modelling, biomechanics and genetic analysis of bird beak development with the study of dinosaur fossils, this project expects to reveal the underlying processes controlling the growth and evolution of beaks. The anticipated goal of this project is to show the power of new theoretical models to explain the diversity of life.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100308
Funder
Australian Research Council
Funding Amount
$435,748.00
Summary
Effects of artificial light at night on coastal ecosystems. This project aims to determine the ecological effects of artificial light at night on coastal marine ecosystems. Artificial light at night is a pervasive stressor that disrupts a fundamental driver of ecological and evolutionary processes: natural light cycles. Using a holistic approach that combines field experiments and microbial ecology, this project will assess impacts of artificial light at multiple levels of biological and ecologi ....Effects of artificial light at night on coastal ecosystems. This project aims to determine the ecological effects of artificial light at night on coastal marine ecosystems. Artificial light at night is a pervasive stressor that disrupts a fundamental driver of ecological and evolutionary processes: natural light cycles. Using a holistic approach that combines field experiments and microbial ecology, this project will assess impacts of artificial light at multiple levels of biological and ecological organisation. Expected outcomes include new knowledge on how species interactions mediate functional changes in response to an emergent, global stressor. This should provide significant benefits, including enhanced management of coastal systems and the critical services and social benefits they provide.
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Suboptimal Sleep And Unhealthy Brain Ageing: Improving Outcomes Through Treatment
Funder
National Health and Medical Research Council
Funding Amount
$632,705.00
Summary
My research will address limitations in our understanding of the impact of sleep characteristics on memory and thinking abilities and biological markers of brain health in older adults, by; 1) exploring these relationships over time, and 2) enabling direct assessment of the effect of improved sleep on memory and thinking, and markers of brain health, following sleep-improvement therapy. My results will contribute to the development of strategies aimed at promoting healthy brain ageing.