Cognition In Motion: Characterization And Evolution Of Cognitive Dysfunction In Motor Neurodegeneration And Frontotemporal Dementia
Funder
National Health and Medical Research Council
Funding Amount
$604,106.00
Summary
Motor neuron disease (MND) is a fatal disease. Cognition may be unaffected or may be severely impaired to warrant a dementia diagnosis. The cognitive status at onset, its progression and the presence of co-morbid dementia of most MND patients is unknown. This research program will develop and validate a cognitive screener that diagnosis co-morbid dementia in the context of motor neurodegeneration in MND.
Developing Insight Into The Molecular Origins Of Familial And Sporadic Frontotemporal Dementia And Amyotrophic Lateral Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$6,377,279.00
Summary
There is strong evidence that frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) represent a spectrum of neurodegenerative disease with common origins. A combined study of FTD/ALS patient cohorts will provide greater power to identify these shared molecular origins. We aim to discover gene variants that cause, predispose, or modify onset and progression of inherited and sporadic FTD/ALS, and validate and study our discoveries in new cell and animal models of these disorders.
BRAIN-MEND: Biological Resource Analysis To Identify New Mechanisms And Phenotypes In Neurodegenerative Diseases
Funder
National Health and Medical Research Council
Funding Amount
$861,866.00
Summary
Current classification of neurodegenerative diseases (ND) based on clinical phenotypes does not take into account underlying disease heterogeneity, or overlapping disease mechanisms, thus hindering therapy development. Segregation and re-classification of ND phenotypes is urgently needed. BRAIN-MEND will reclassify existing phenotypic classifications using using pathway and network analyses within and across complex NDs.