Neuronal Regulation Of Systemic Mitochondrial Stress
Funder
National Health and Medical Research Council
Funding Amount
$865,605.00
Summary
Mitochondria are the powerhouses of cells. They generate energy from the food we eat and air we breathe. However, excess nutrients can cause mitochondrial stress and damage that lead to disease. The objective of this research is to understand how the brain regulates mitochondrial stress responses throughout the body. Therefore, this project will identify stress-response processes that are directly relevant to health and disease.
Development Of An Intracellular Tau-specific Antibody Therapeutic For The Treatment Of Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$410,378.00
Summary
The protein, tau, is a promising therapeutic target for the treatment of Alzheimer's disease and related dementia's. Targeting tau is a challenge, however, as it is mostly localised within brain cells and a therapeutic must therefore be able to cross multiple barriers to engage and neutralise tau. This project overcomes this hurdle by using virus' to deliver a tau-specific antibody gene across the multiple barriers where it can be produced by brain cells and target intracellular tau.