The Molecular Basis For Target Selection In The Central Nervous System By Sensory Axons
Funder
National Health and Medical Research Council
Funding Amount
$251,325.00
Summary
The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct conne ....The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct connections following injury to the brain or spinal cord. We propose to use a simple model system, the embryo of the fruitfly Drosophila, to find molecules that are involved in this process of neuron target recognition - ' axon targeting' molecules - and to study how they work. Drosophila can be genetically manipulated in ways not possible in higher animals. Furthermore the simplicity of its nervous system means that we can determine the connections of individual nerve cells with a high degree of precision. In the first part of our project, we will examine Drosophila embryos that carry mutations in genes suspected to code for targeting molecules. We will stain individual sensory nerve cells in these embryos with dyes to reveal the anatomy of their axons in the brain. If sensory axons terminate abnormally in the brain of a given mutant, the affected gene is likely to code for an axon targeting molecule. In the second part of the study, we will investigate the functions of candidate axon targeting molecules using two approaches. Firstly, we will seek to determine whether the molecule acts in the sensory axons or in their target cells. Secondly, we will use time-lapse microscopy to study how the homing behaviour of the sensory axons is affected in mutant embryos. The results of these studies will lead us closer to an answer to the question: How do axons recognise their specific target cells in the brain?Read moreRead less
Representation of gender and sexual diversity in Australian film and television. This project aims to investigate the cultural, health and identity impact of gender/sexually-diverse characters, themes and narratives in Australian film and television from 1990 to present. The project expects to generate new knowledge by providing the first comprehensive account of Australian media production’s contribution to sexual minority representation, in the context of its importance for fostering healthy i ....Representation of gender and sexual diversity in Australian film and television. This project aims to investigate the cultural, health and identity impact of gender/sexually-diverse characters, themes and narratives in Australian film and television from 1990 to present. The project expects to generate new knowledge by providing the first comprehensive account of Australian media production’s contribution to sexual minority representation, in the context of its importance for fostering healthy identities, and acceptance of minorities to mainstream audiences in a digital media era. This knowledge will provide significant benefit to the mental health, wellbeing and social harmony for both minority and mainstream Australians and help showcase an important aspect of Australian media inclusivity and diversity in international scholarship.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100118
Funder
Australian Research Council
Funding Amount
$387,882.00
Summary
Empowering vulnerable youth in Australia by combatting linguistic racism. This project aims to investigate how culturally and linguistically diverse young Australians experience discrimination in their daily lives because of how they speak.The project will generate new knowledge addressing the critical need to review the linguistic disparity experienced by bi/multilingual speakers. Major benefits are policy recommendations to improve health and welfare of the population.
Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internatio ....Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internationalisation strategies and consumption of Chinese culture on digital platforms in China, Australia, Hong Kong, Singapore and South Korea. It expects to understand the implications of China's digital ascendency and the lessons for Australia in the post-resources boom era.Read moreRead less
Living Together: New Approaches to Multispecies Conflict and Coexistence. Building on the methods and concepts of the emerging environmental humanities, this project will produce a new conceptual vocabulary for a world in which multispecies conflict and coexistence is increasingly important. It brings critical and generative rereadings of classical political thought and contemporary biopolitical and cosmopolitical approaches into dialogue with a set of empirical case studies emerging from novel ....Living Together: New Approaches to Multispecies Conflict and Coexistence. Building on the methods and concepts of the emerging environmental humanities, this project will produce a new conceptual vocabulary for a world in which multispecies conflict and coexistence is increasingly important. It brings critical and generative rereadings of classical political thought and contemporary biopolitical and cosmopolitical approaches into dialogue with a set of empirical case studies emerging from novel encounters between humans and other animals. This project will expand Australia’s knowledge base and research capacity in the interdisciplinary environmental humanities and stake out new approaches to the question of living together in a changing environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100789
Funder
Australian Research Council
Funding Amount
$401,808.00
Summary
Social media influencers as conduits of knowledge in Australia and Asia. This project aims to evaluate how social media influencers can become conduits to communicate information among young people between Australia and East Asia. As icons on the internet who are experts in holding attention and amplifying content, influencers have expanded from being mere commercial enterprises to being conduits of public service information by reaching wide, diverse, and sometimes marginalised youth audiences ....Social media influencers as conduits of knowledge in Australia and Asia. This project aims to evaluate how social media influencers can become conduits to communicate information among young people between Australia and East Asia. As icons on the internet who are experts in holding attention and amplifying content, influencers have expanded from being mere commercial enterprises to being conduits of public service information by reaching wide, diverse, and sometimes marginalised youth audiences with important socio-cultural messages. This project will glean lessons from leading influencer ecologies in East Asia (Seoul, Shanghai and Tokyo), to understand how we can use internet-native communication formats to improve inter-cultural knowledge and relations in Australia.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100046
Funder
Australian Research Council
Funding Amount
$3,224,956.00
Summary
Desert People: Australian Perspectives . This project will bring innovative science and Indigenous knowledge together to develop new understandings of the 60,000 year custodianship of Australian deserts. The archaeology will focus on the Ningaloo coast, Pilbara and Western Desert. This region is experiencing expansion in resource extraction, energy production and tourism, key to Australia's post-COVID recovery. This globally significant human record is poorly documented and at risk, as seen in t ....Desert People: Australian Perspectives . This project will bring innovative science and Indigenous knowledge together to develop new understandings of the 60,000 year custodianship of Australian deserts. The archaeology will focus on the Ningaloo coast, Pilbara and Western Desert. This region is experiencing expansion in resource extraction, energy production and tourism, key to Australia's post-COVID recovery. This globally significant human record is poorly documented and at risk, as seen in the recent loss of Juukan Caves. The Desert People programme will work with Traditional Owners and use novel techniques to document places of the highest value for their management and protection. This will result in vastly improved planning outcomes and underwrite new regional economies. Read moreRead less
Using community engagement and enhanced visual information to promote FireWatch satellite communication as a support for collaborative decision-making. Using continuously updated satellite data, FireWatch will repurpose its professional service for use by the wider public, informing community-based decision-making and action. Communication flows and community decision-making will promote informed action at times of fire stress. Complex visual data will be communicated in clear and compelling way ....Using community engagement and enhanced visual information to promote FireWatch satellite communication as a support for collaborative decision-making. Using continuously updated satellite data, FireWatch will repurpose its professional service for use by the wider public, informing community-based decision-making and action. Communication flows and community decision-making will promote informed action at times of fire stress. Complex visual data will be communicated in clear and compelling ways.Read moreRead less
Perceptions of harm from adolescents accessing online sexual content. This project aims to investigate Australian adolescents’ responses to online sexual content through a comparative communication-based study with teens in Greece, Ireland and Norway. The project seeks to generate knowledge through in-depth interviews with Australian high school students, aged 12-17, and their parents, comparing their perceptions with children and parents from other countries. The project will combine qualitativ ....Perceptions of harm from adolescents accessing online sexual content. This project aims to investigate Australian adolescents’ responses to online sexual content through a comparative communication-based study with teens in Greece, Ireland and Norway. The project seeks to generate knowledge through in-depth interviews with Australian high school students, aged 12-17, and their parents, comparing their perceptions with children and parents from other countries. The project will combine qualitative and quantitative data to explore why Australian teens might access sexual media more often than their peers overseas, and be more likely to feel bothered by it. Expected outcomes include strategies to support teens who feel affected by access to online sexual content, thus minimising negative impacts.Read moreRead less
A Cross-National and Cross-Cultural Study of Global Translation Industry. This project aims to tackle the pressing issue of the social invisibility of the translation profession, a persistent social problem that threatens to hinder the development of a critical knowledge-based industry in Australia within a rapidly changing international social, economic and cultural context. The project is expected to offer insights into the emerging international translation system and inform policy makers an ....A Cross-National and Cross-Cultural Study of Global Translation Industry. This project aims to tackle the pressing issue of the social invisibility of the translation profession, a persistent social problem that threatens to hinder the development of a critical knowledge-based industry in Australia within a rapidly changing international social, economic and cultural context. The project is expected to offer insights into the emerging international translation system and inform policy makers and the general public about the challenges and opportunities of developing this profitable and resilient service industry.Read moreRead less