Cellular Mechanisms Controlling Neural Crest Cell Migration Along The Developing Gut
Funder
National Health and Medical Research Council
Funding Amount
$368,895.00
Summary
Within the wall of the gut, there are a large number of neurons, probably more than are in the spinal cord. These enteric neurons play an essential role in controlling a number of gut functions including peristalsis (the propulsion of contents along the gut). Most of the neurons in the gut, including those in the large intestine, arise from precursors that emigrate from the hindbrain, and then migrate into and along the gastrointestinal tract during development. The colonization of the gut by ne ....Within the wall of the gut, there are a large number of neurons, probably more than are in the spinal cord. These enteric neurons play an essential role in controlling a number of gut functions including peristalsis (the propulsion of contents along the gut). Most of the neurons in the gut, including those in the large intestine, arise from precursors that emigrate from the hindbrain, and then migrate into and along the gastrointestinal tract during development. The colonization of the gut by neuron precursors takes 5 days in mice and 6 weeks in humans. Studies of the mechanisms controlling the migration of neuron precursors along the gut have provided fundamental information about cell migration in general. Genetic studies in humans and mice have identified some of the genes that are necessary for the migration of neuron precursors along the gastrointestinal tract, but for some of the key genes, their precise role is unknown. We have recently developed a method for imaging living neuron precursors migrating through explants of embryonic mouse gut. In the current proposal we will meld imaging and genetic studies to understand how mutations in particular genes lead to migration defects. In particular, how do particular mutations affect the migratory behaviour of enteric neural precursors? We have also previously shown that neuron precursors migrate along the gut in close association with axons. We will examine the nature of these interactions - in particular, who is following whom, and what happens when cell migration and axon growth are uncoupled? These studies, which will investigate a number of critical aspects of the migration of neural precursors into and along the developing gut, are central to understanding how the enteric nervous system is established along the gastrointestinal tract.Read moreRead less
The Role Of Microglia In Early Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$665,582.00
Summary
Diabetic retinopathy is one of the most feared complications of diabetes. This project will examine the role that retinal immune cells called microglia have in causing early changes in the vasculature. We will examine whether diabetes changes the way neurons communicate with blood vessels, opening up a possible treatment target that could prevent the progression to more advanced disease.
Iron-Infection Interactions: Studies Of The Link Between Iron Metabolism And Infectious Diseases Of Global Significance
Funder
National Health and Medical Research Council
Funding Amount
$383,244.00
Summary
Anaemia, malaria and HIV affect millions of people worldwide, but interactions between these conditions are poorly understood. A haematologist with training in public health, my interest is in finding ways to control the enormous global burden of anaemia. My research will focus on how iron status influences infection with malaria and HIV. It will provide evidence for anaemia control guidelines and help improve global policies for controlling iron deficiency where these infections coexist.
Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing politi ....Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing political structures - has become a central symbolic weapon in the French State's political defence of cultural autonomy and difference in a globalising world. The resulting synthesis will provide extensive new understanding of the dynamics of contemporary France.Read moreRead less
The global self: screening the history of human rights in the 20th century to the present. This project will research the history and theory of human rights as represented in film and new media. It will analyse the origins and development of human rights theory and document the changes in films about human rights in order to understand how we now conceptualise human rights in the twenty-first-century.
Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formati ....Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formations of cultural identity. Through scholarly publications, the study will make major contributions to our understanding of not only gay culture and history, but the significance of celebrity in modern cultural life.Read moreRead less
Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such ....Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such problems, and significantly advance Aboriginal English research, by exploring culturally constructed conceptualisations, in particularly cultural-conceptual metaphor, underlying the use of Aboriginal English, using the the analytical tools of Cultural Linguistics. The study will also make a significant contribution to the development of Cultural Linguistics. Read moreRead less
Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belongin ....Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belonging’. In doing so, the project forges links between cultural studies of storytelling, LGBTIQ+ youth studies and Australian history. Benefits include innovations in reparative historical methodologies, new resources for the GLAM, youth and education sectors and improvements in LGBTIQ+ youth wellbeing.Read moreRead less
The Molecular Basis For Target Selection In The Central Nervous System By Sensory Axons
Funder
National Health and Medical Research Council
Funding Amount
$251,325.00
Summary
The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct conne ....The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct connections following injury to the brain or spinal cord. We propose to use a simple model system, the embryo of the fruitfly Drosophila, to find molecules that are involved in this process of neuron target recognition - ' axon targeting' molecules - and to study how they work. Drosophila can be genetically manipulated in ways not possible in higher animals. Furthermore the simplicity of its nervous system means that we can determine the connections of individual nerve cells with a high degree of precision. In the first part of our project, we will examine Drosophila embryos that carry mutations in genes suspected to code for targeting molecules. We will stain individual sensory nerve cells in these embryos with dyes to reveal the anatomy of their axons in the brain. If sensory axons terminate abnormally in the brain of a given mutant, the affected gene is likely to code for an axon targeting molecule. In the second part of the study, we will investigate the functions of candidate axon targeting molecules using two approaches. Firstly, we will seek to determine whether the molecule acts in the sensory axons or in their target cells. Secondly, we will use time-lapse microscopy to study how the homing behaviour of the sensory axons is affected in mutant embryos. The results of these studies will lead us closer to an answer to the question: How do axons recognise their specific target cells in the brain?Read moreRead less
Transforming Cultural Identity: Media flows between Australia and East Asia. By evaluating Australia's role in East Asian media circuits, this project aims to identify new industry and consumer trends. The rise of East Asian media industries, estimated to be worth US$120 billion and reaching at least 2 billion consumers, is changing Australian media culture. While East Asian media reach in to Australian audiences via new media, Australian media industries are reaching out to Asia via transnation ....Transforming Cultural Identity: Media flows between Australia and East Asia. By evaluating Australia's role in East Asian media circuits, this project aims to identify new industry and consumer trends. The rise of East Asian media industries, estimated to be worth US$120 billion and reaching at least 2 billion consumers, is changing Australian media culture. While East Asian media reach in to Australian audiences via new media, Australian media industries are reaching out to Asia via transnational co-productions. This project plans to examine these trends in media consumption and production to analyse impacts on the cultural identities of Australian audiences and media products. Through the innovative framework of minor transnationalism, it plans to produce a deeper understanding of the nation's relationship with its region.Read moreRead less