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Hereditary Motor Neuronopathies And Neuropathies: Mechanisms Of Neurodegeneration And Potential Modification.
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
The aim of the study is to investigate the pathophysiology of motor neuron degeneration in its various acquired and inherited forms. Nerve function will be determined by clinical and neurophysiological assessments in patients. The findings of the study will reveal further insights into the cause and progression of disorders of the motor neuron. This data may function to monitor disease progression, response to potential therapies and lead to the development of further therapeutic strategies.
Development Of A New Method Of Motor Unit Number Estimation For Use In Motor Neurone Disease
Funder
National Health and Medical Research Council
Funding Amount
$480,127.00
Summary
This project aims to help understand motor neurone disease, which is a severe disease that leads to paralysis and death. In motor neurone disease there is of death of the nerve cells that maks muscles move. We have developed a new method of measuring the number of motor nerve cells. We will use this to study the different types of motor neurone disease.
Flecainide In Amyotrophic Lateral Sclerosis - A Neuroprotective Strategy
Funder
National Health and Medical Research Council
Funding Amount
$593,275.00
Summary
This project will provide clinical trial information related to the potential neuroprotective properties of flecainide in motor neurone disease patients. A potential therapeutic response would provide impetus for a larger scale, multi-centre clinical trial. In addition to providing information about potential mechanisms of neurodegeneration and their treatment, new quantifiable measures will be further developed to objectively monitor MND patients in a clinical trials setting.