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Discovery Early Career Researcher Award - Grant ID: DE120102961
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The role of the unfolded protein response in tau neurobiology and pathology. The main role of the protein tau is the stabilisation of the scaffolding of cells. In a group of dementias, tau forms abnormal clumps within the cells of the brain causing them to die. This project will investigate the cellular processes involved in normally preventing tau proteins from clumping and their role in the development of the abnormal tau clumps.
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Prediction of tissue fate and functional outcome in acute ischemic stroke with advanced imaging analysis - experimental validation and translational studies. Stroke is predominantly a disease of ageing and the commonest cause of adult disability. In Australia, 55,000 people have a stroke each year (>80% are over age 65). The total number of strokes per year worldwide will rise 60% within the next two decades as the proportion of elderly in our population increases. This research will improve bra ....Prediction of tissue fate and functional outcome in acute ischemic stroke with advanced imaging analysis - experimental validation and translational studies. Stroke is predominantly a disease of ageing and the commonest cause of adult disability. In Australia, 55,000 people have a stroke each year (>80% are over age 65). The total number of strokes per year worldwide will rise 60% within the next two decades as the proportion of elderly in our population increases. This research will improve brain imaging selection for acute stroke therapies in clinical trials and practice. Better acute stroke therapies limit the size of brain damage from stroke and reduce long-term disability. Thus, this research will directly translate into allowing our population to 'age well and productively'.Read moreRead less