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Prediction of epilepsy seizure onset using nonlinear analysis of EEG recordings. This project will develop the theory and algorithms for reliable and robust prediction of the onset of epileptic seizures and the characterisation of epileptic seizures based on EEG data. Our interdisciplinary team consists of neuroscientists and systems engineers supported with clinicians and software developers. The team will develop the theory and design, implement and evaluate decision support software that is a ....Prediction of epilepsy seizure onset using nonlinear analysis of EEG recordings. This project will develop the theory and algorithms for reliable and robust prediction of the onset of epileptic seizures and the characterisation of epileptic seizures based on EEG data. Our interdisciplinary team consists of neuroscientists and systems engineers supported with clinicians and software developers. The team will develop the theory and design, implement and evaluate decision support software that is able to interpret eeg data and present epilepsy relevant information to clinicians and patients. Our methods are based on statistical signal processing, nonlinear dynamics (bifurcation and time-series methods) and systems engineering (system identification, adaptive methods).Read moreRead less
Optimisation of signal processing and electrical stimulation algorithms for the abatement of epileptic seizures. Epilepsy is the second-most common neurological disorder behind stroke and ischemic attacks, affecting 1-2 per cent of the nation's population. Pharmaceutical therapies are ineffective in approximately one third of cases, the result being a large unmet need for novel treatments. The devices to be produced through this project will improve the quality of life of many patients in the fu ....Optimisation of signal processing and electrical stimulation algorithms for the abatement of epileptic seizures. Epilepsy is the second-most common neurological disorder behind stroke and ischemic attacks, affecting 1-2 per cent of the nation's population. Pharmaceutical therapies are ineffective in approximately one third of cases, the result being a large unmet need for novel treatments. The devices to be produced through this project will improve the quality of life of many patients in the future and alleviate their dependence on traditional medications. The devices will also reduce the patients' requirements for medical practitioners, hospital and ambulance services, and will therefore also reduce the financial burden that neurological and epilepsy patients place on the community.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Increasing the utility of tetanus toxins by protein engineering. There are a variety of common diseases that are the result of muscular defects. Some of these may be able to be treated with an agent that increases muscle tone, thereby giving benefit to the patient in the alleviation of symptoms. This project aims to use some of the most potent substances known, bacterial toxins, and engineer them to be valuable agents for treatment of certain muscular disorders.
Predicting the evolution of psychosocial and cognitive difficulties in epilepsy: A preventive approach. Chronic epilepsy is associated with significant psychosocial and cognitive difficulties. Research has neglected to examine how these problems evolve from the time of a first seizure, limiting our ability to predict ?at risk? patients and apply evidence-based preventive strategies. We will follow a cohort of 90 first seizure patients over two years in a prospective longitudinal investigation, m ....Predicting the evolution of psychosocial and cognitive difficulties in epilepsy: A preventive approach. Chronic epilepsy is associated with significant psychosocial and cognitive difficulties. Research has neglected to examine how these problems evolve from the time of a first seizure, limiting our ability to predict ?at risk? patients and apply evidence-based preventive strategies. We will follow a cohort of 90 first seizure patients over two years in a prospective longitudinal investigation, mapping psychosocial and cognitive change. This study entails a multidisciplinary collaboration with industry, applying innovative psychosocial and cognitive measures that will ultimately improve the detection of adverse pharmaceutical side-effects. The project is an international first, and will provide an important foundation for implementing preventive healthcare.Read moreRead less
Elucidating the neurobiological basis for developmental stuttering using modern brain imaging techniques. We plan to untilise brain imaging techniques to examine the neurological underpinnings of stuttering. We aim to develop new tools for functional magnetic resonance imaging (fMRI) to examine the patterns of brain activation in the motor, speech and language areas, specifically for use in children who stutter. We aim to answer the question of whether stuttering is a motor-speech or a language ....Elucidating the neurobiological basis for developmental stuttering using modern brain imaging techniques. We plan to untilise brain imaging techniques to examine the neurological underpinnings of stuttering. We aim to develop new tools for functional magnetic resonance imaging (fMRI) to examine the patterns of brain activation in the motor, speech and language areas, specifically for use in children who stutter. We aim to answer the question of whether stuttering is a motor-speech or a language disorder and to establish whether variations in the speech and language regions of the brain found in adult stuttering research are also present in children who stutter, and to explore the possibility that different variations in brain activation and/or morphology may predict persistence and recovery.
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