Molecular Targets Involved In Human Muscle Atrophy And Hypertrophy
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Muscle wasting is a consequence of aging, cancer, HIV-AIDS, obesity and work-sport injuries. It increases the risk of injury, impacts on recovery and places an economic burden on our healthcare system. Atrogin-1 and STARS are muscle specific genes believed to regulate muscle mass. This project aims to determine how human atrogin-1 and STARS are regulated and how they can influence muscle loss. These studies may provide new targets for reducing human muscle wasting.
Diabetic neuropathy causes severe disability, with pain, loss of sensation and weakness. The current project will assess the utility of a new testing method, known as nerve excitability assessment, as a method of detecting early changes in nerve function in diabetic patients. If this technique proves useful in detecting early nerve damage, it will assist in the development of therapeutic and preventative treatments for neuropathy in diabetic patients.
From Measurement To Management Of Inherited Neuromuscular Disorders
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
Neuromuscular disorders can damage muscle, motor neurone or nerves, causing progressive weakness, disability and poor quality of life. Three themes of research will improve treatment of the most common nerve disorder, Charcot-Marie-Tooth disease. The research will use state-of-the-art measurement tools, ensuring research translation through multicentre trials and best-practice guidelines. The goal is to reduce the burden on patient and society and promote excellence and innovation for nerve and ....Neuromuscular disorders can damage muscle, motor neurone or nerves, causing progressive weakness, disability and poor quality of life. Three themes of research will improve treatment of the most common nerve disorder, Charcot-Marie-Tooth disease. The research will use state-of-the-art measurement tools, ensuring research translation through multicentre trials and best-practice guidelines. The goal is to reduce the burden on patient and society and promote excellence and innovation for nerve and muscle research.Read moreRead less