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Understanding multiday cycles underpinning human physiology. We recently discovered long-term rhythms modulating activities of our brains and hearts ranging in duration from 3-60 days. The cause of these longer, ‘multiday cycles’ remain unknown. This project aims to understand; causes of multiday cycles (measuring the nervous and autonomic nervous system), their effects (on cognition, sleep, and stress), and quantify the relationship between coupled cyclical systems. The research outcomes can pr ....Understanding multiday cycles underpinning human physiology. We recently discovered long-term rhythms modulating activities of our brains and hearts ranging in duration from 3-60 days. The cause of these longer, ‘multiday cycles’ remain unknown. This project aims to understand; causes of multiday cycles (measuring the nervous and autonomic nervous system), their effects (on cognition, sleep, and stress), and quantify the relationship between coupled cyclical systems. The research outcomes can provide fundamental new knowledge about cyclic dynamics governing human physiology, leading to improved rigour in life sciences research. Commercial outcomes include technology to optimise individual productivity, learning, health, and wellbeing based on physiological cycles, with diverse benefits to society.Read moreRead less
Novel tractography-guided MRI methods for studying healthy brain ageing. Advances in imaging, and particularly Magnetic Resonance Imaging, have opened a new era in the study of the brain enabling a myriad of neuroscience discoveries. This project aims to develop new analysis methods to study and understand the variability in the human brain during ageing, exploiting the wealth of information contained in the so-called tractogram, a mapping of the brain’s wiring. This project expects to develop i ....Novel tractography-guided MRI methods for studying healthy brain ageing. Advances in imaging, and particularly Magnetic Resonance Imaging, have opened a new era in the study of the brain enabling a myriad of neuroscience discoveries. This project aims to develop new analysis methods to study and understand the variability in the human brain during ageing, exploiting the wealth of information contained in the so-called tractogram, a mapping of the brain’s wiring. This project expects to develop innovative imaging biomarkers to characterise the brain changes in the course of healthy brain ageing. Expected outcomes include novel imaging tools for neuroscience, which should allow us to map trajectories of normative healthy brain ageing and use them to identify lifestyle factors that impact these trajectories.Read moreRead less
Novel mechanisms by which retinal microglia regulate vascular development. This project aims to investigate how immune cells called microglia refine the developing retinal vasculature. New knowledge utilizing state of art imaging techniques is likely to be examine a completely novel mechanism by which vascular development occurs. This information is critical for enhancing our understanding of the role of immune cells in the nervous system and will guide the development of new ways of examining t ....Novel mechanisms by which retinal microglia regulate vascular development. This project aims to investigate how immune cells called microglia refine the developing retinal vasculature. New knowledge utilizing state of art imaging techniques is likely to be examine a completely novel mechanism by which vascular development occurs. This information is critical for enhancing our understanding of the role of immune cells in the nervous system and will guide the development of new ways of examining these cells. Expected outcomes include a novel way for assessing microglia in the developing nervous system and new knowledge. In the longer term the information gained in this project may be helpful for understanding scenarios where blood vessels are abnormal, or for using microglia as a target to modify vascular function.Read moreRead less
Visualising Retinal Microglia as a Window into Brain Inflammation. This project aims to use the unique autofluorescence signature of immune cells, microglia, imaged in the retina, as an index of brain inflammation. This project expects to provide the fundamental knowledge to allow us to image microglia non-invasively and identify the presence of brain inflammation without needing to access the brain-proper. Expected outcomes include full characterisation of microglial autofluorescence in the ret ....Visualising Retinal Microglia as a Window into Brain Inflammation. This project aims to use the unique autofluorescence signature of immune cells, microglia, imaged in the retina, as an index of brain inflammation. This project expects to provide the fundamental knowledge to allow us to image microglia non-invasively and identify the presence of brain inflammation without needing to access the brain-proper. Expected outcomes include full characterisation of microglial autofluorescence in the retina and how it relates to brain inflammation. This should provide significant downstream benefits for the detection of inflammatory brain disease well before visible symptoms develop with substantial benefit for livestock, pets, zoo and conservation animals, as well as research knowledge. Read moreRead less
The capacity for exceptional brain repair in a novel rodent species. This project aims to provide a new and much-needed living tool for studying brain injury and repair. The project expects to generate new evidence of effective brain repair in a mammalian species, the spiny mouse. In particular, it will provide important knowledge of the cellular responses that coordinate to allow mammalian brain repair, revealing targets for future understanding and treatment. Expected outcomes include an in-de ....The capacity for exceptional brain repair in a novel rodent species. This project aims to provide a new and much-needed living tool for studying brain injury and repair. The project expects to generate new evidence of effective brain repair in a mammalian species, the spiny mouse. In particular, it will provide important knowledge of the cellular responses that coordinate to allow mammalian brain repair, revealing targets for future understanding and treatment. Expected outcomes include an in-depth characterisation of how neurons and non-neuronal cells (glia) contribute to brain repair, and the identification of new pathways or targets for mammalian brain repair. In the long-term this should provide significant benefits for future research focused on improving the lives of people affected by brain injury. Read moreRead less
What drives the Anterior Expansion of the Central Nervous System? A striking and highly conserved feature of the central nervous system is that the brain is larger than the spinal cord. Despite the manifest implications this has for nervous system function, the underlying drivers are largely unknown. This project aims to investigate the mechanisms controlling anterior expansion of the central nervous system, and will generate new knowledge in the areas of nervous system development and evolution ....What drives the Anterior Expansion of the Central Nervous System? A striking and highly conserved feature of the central nervous system is that the brain is larger than the spinal cord. Despite the manifest implications this has for nervous system function, the underlying drivers are largely unknown. This project aims to investigate the mechanisms controlling anterior expansion of the central nervous system, and will generate new knowledge in the areas of nervous system development and evolution. This project aims to impact on our understanding of nervous system function, develop bioinformatics tools with broad utility within the biosciences field, strengthen Australia’s international standing in the developmental neuroscience, and enhance the capacity for interdisciplinary international collaborations.Read moreRead less