Development of integrated biological markers of brain function. With the rapid growth of both brain imaging and genetics, we can now examine the biological basis of complex brain functions, such as memory. Our goal is to combine these techniques to develop evidence-based biological markers of normal function. These markers can then be used to screen for early signs of abnormal function (eg. in Alzheimer's disease) and to assess treatment effects. Two unique features ensure the project's feasibil ....Development of integrated biological markers of brain function. With the rapid growth of both brain imaging and genetics, we can now examine the biological basis of complex brain functions, such as memory. Our goal is to combine these techniques to develop evidence-based biological markers of normal function. These markers can then be used to screen for early signs of abnormal function (eg. in Alzheimer's disease) and to assess treatment effects. Two unique features ensure the project's feasibility: a) access to the first standardized, normative brain database (from the Brain Resource Company Ltd) and b) a scientific collaboration supporting the integration of brain imaging and genetics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101102
Funder
Australian Research Council
Funding Amount
$378,536.00
Summary
Memory Engram Storage and Retrieval. This project aims to probe how long-term memory is stored in the brain. Recently, memory engram-labelling technology has revolutionised the way memory can be experimentally studied. It is now known that sparse populations of neurons that were active during a defined training window are both sufficient and necessary for retrieval of specific memories, and that activation of hippocampal engram causes further downstream activity in connected engram cells of othe ....Memory Engram Storage and Retrieval. This project aims to probe how long-term memory is stored in the brain. Recently, memory engram-labelling technology has revolutionised the way memory can be experimentally studied. It is now known that sparse populations of neurons that were active during a defined training window are both sufficient and necessary for retrieval of specific memories, and that activation of hippocampal engram causes further downstream activity in connected engram cells of other brain regions. However, it is unknown whether engram cell connectivity is important for memory function. The project aims to test this question. Understanding more about memory function in normal conditions may help us to understand and treat disorders of memory.Read moreRead less
The genetic basis of human memory. This project will examine the relationship between genetic variation and performance of normal individuals on a comprehensive range of memory test indicators. Results of the study will clarify the genetic basis of human memory and provide a better understanding of this important function.
The articulate brain. Language is essential to human interaction, yet we know comparatively little about the mental processes involved and how they are represented in the brain, how genetic and environmental factors contribute to the development of language, or how effective treatments of language disorders work. The significance of this program of research lies in its capacity to enhance our understanding of a range of mechanisms responsible for a fundamentally human ability, and provide inform ....The articulate brain. Language is essential to human interaction, yet we know comparatively little about the mental processes involved and how they are represented in the brain, how genetic and environmental factors contribute to the development of language, or how effective treatments of language disorders work. The significance of this program of research lies in its capacity to enhance our understanding of a range of mechanisms responsible for a fundamentally human ability, and provide information that will ultimately inform clinical practice. In particular, new knowledge about the brain mechanisms involved in language processing and recovery will inform clinicians about the optimal choice of treatment to maximise outcomes for the individual patient. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882219
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Infrastructure for an integrated cognitive neurophysiological research facility: Mapping the neurobiology of memory and language. The Integrated Cognitive Neurophysiological Research Facility will enhance Australia's national research capacity in cognitive neuroscience by enabling large numbers of researchers and graduate students to investigate the neuroscience of memory and language in a collaborative, multi-disciplinary research environment. The facility will deliver national benefits by unco ....Infrastructure for an integrated cognitive neurophysiological research facility: Mapping the neurobiology of memory and language. The Integrated Cognitive Neurophysiological Research Facility will enhance Australia's national research capacity in cognitive neuroscience by enabling large numbers of researchers and graduate students to investigate the neuroscience of memory and language in a collaborative, multi-disciplinary research environment. The facility will deliver national benefits by uncovering the ways in which areas of the brain are used to remember events and process language. This information can then be used to understand how damage to the brain (such as in stroke or disease) can disrupt memory and language and subsequently lead to more effective neurorehabilitation techniques.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100088
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Central nervous system insulin and hippocampal-dependent cognitive function. This project plans to examine the effects of both infusion of insulin into the brain and the genetic knockdown of insulin transport and activity on cognitive function in mice. This project should increase our understanding of how circulating insulin enters the brain to influence the brain and resulting behaviours.