The Role Of The Neuronal Epigenome In Natural Brain Ageing And The Progression Of Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$584,644.00
Summary
Most cases of Alzheimer's disease are sporadic or late onset, with only ~5% of cases being familial, suggesting a potential role for epigenetics. This project aims to profile the human brain epigenome throughout normal ageing and in Alzheimer's disease so we can determine how disturbed epigenetic states may affect brain function. This research will provide new insights into the role of the epigenome in Alzheimer's disease, enabling crucial advances in understanding its origins.
Longitudinal Transcriptome Profiles For People With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$475,913.00
Summary
Over the past decade, less than half a percent of drugs trialled for Alzheimer Disease were found to be effective. This highlights the need for new drug targets. This Fellowship aims to study how genes express themselves over time, among people with very high risk of dementia (genetic form of Alzheimer Disease and Huntington Disease). By looking at gene expression in nerve tissue in the nose, fluid around the brain, and blood, I hope to better understand the disease mechanisms causing dementia.
Developing Insight Into The Molecular Origins Of Familial And Sporadic Frontotemporal Dementia And Amyotrophic Lateral Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$6,377,279.00
Summary
There is strong evidence that frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) represent a spectrum of neurodegenerative disease with common origins. A combined study of FTD/ALS patient cohorts will provide greater power to identify these shared molecular origins. We aim to discover gene variants that cause, predispose, or modify onset and progression of inherited and sporadic FTD/ALS, and validate and study our discoveries in new cell and animal models of these disorders.
Genetic Biomarkers And Molecular Pathways For Migraine
Funder
National Health and Medical Research Council
Funding Amount
$273,988.00
Summary
Common migraine, is a frequent, debilitating and painful disorder that affects people during their most productive years (up to 25% of women and 8% of men). Our recent results indicate the presence of multiple genetic factors contributing towards migraine susceptibility. Utilising detailed migraine symptom and medication data, larger numbers of migraine cases and controls, and applying the latest genotyping and imputation technologies, we will identify novel genetic biomarkers and molecular path ....Common migraine, is a frequent, debilitating and painful disorder that affects people during their most productive years (up to 25% of women and 8% of men). Our recent results indicate the presence of multiple genetic factors contributing towards migraine susceptibility. Utilising detailed migraine symptom and medication data, larger numbers of migraine cases and controls, and applying the latest genotyping and imputation technologies, we will identify novel genetic biomarkers and molecular pathways for migraine.Read moreRead less