Understanding The Mechanisms Of PTEN Transfer Into Glial Cells Using Exosomes
Funder
National Health and Medical Research Council
Funding Amount
$567,253.00
Summary
This application will develop a new way of treating brain cancer which currently affects 1500 adults in Australia per year with no lasting cures. The average patient with a malignant brain tumour do not survive for more than 12 months. We have discovered a method of restoring a cancer suppressor substance that is lost from brain tumours. If successful, this treatment has the potential to limit or reverse the progression of brain tumours.
An Integrated “omic” Approach To Neurodevelopmental Disorders Using Disease-discordant Monozygotic Twins
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
This project targets neurodevelopment disorders such as autism spectrum disorder, cerebral palsy and epilepsy and focuses on studying the environmental factors (epigenetics) affecting the disease mechanisms in these disorders. The study will be performed on twin samples and will help in the diagnosis of the disease risk at an earlier stage. It will also help to understand the causes of these important neurological diseases.
Cerebral Palsy (CP) is a devastating, common developmental brain disorder once assumed to be due to lack of oxygen at birth. Using our unique Biobank with DNA and clinical data from families with a CP child, we are examining the genetic origins of CP and how genes and risk factors in pregnancy contribute. We will use computer modelling and testing in animals and brain cells, to understand causes of CP and devise predictive, preventative and therapeutic strategies.
Delayed Radial Glial Maturation Linked To NFI Deficiency As An Underlying Cause Of Cortical Defects In Humans And Mice
Funder
National Health and Medical Research Council
Funding Amount
$801,979.00
Summary
The timely generation of neurons and glia is important for brain development and consequently brain function throughout life. Nuclear factor I (NFI) genes are important for regulating the production of neurons and glia, and people with disrupted NFI genes have severe cognitive and motor deficits. Using human genetic data and mouse models, we will analyse how disrupting these genes affects brain development, and changes the overall structure and wiring of the cerebral cortex as well as behaviour.
Biomonitoring Early Life Exposure To Plastic Products In Australia And Assessing Health Consequences.
Funder
National Health and Medical Research Council
Funding Amount
$405,231.00
Summary
The World Health Organisation states that the health impacts of toxic chemical exposure, including plastics, during early life are a modern research priority. Of potential concern, two plastic product sets – phthalates and phenols may be linked to adverse neurodevelopmental consequences. This project aims to provide greater clarity on exposure levels, determinants and health consequences of early life plastic exposure among modern Australian children and accelerate proactive policy responses.
Aberrant Ependymal Development And The Formation Of Hydrocephalus
Funder
National Health and Medical Research Council
Funding Amount
$660,005.00
Summary
Foetal hydrocephalus is a prevalent neurodevelopmental condition associated with severe intellectual impairment. Breakdown of the ependymal cell layer, which acts as a barrier between brain tissue and the ventricular space, is a major cause of hydrocephalus. Despite the importance of these cells, we have little understanding of the molecular mechanisms that regulate their production. This project will identify critical signalling pathways governing the establishment of the ependymal layer.