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Testing theoretical models of age and disease related changes to inform prevention. Pathological brain changes associated with future cognitive decline become detectable in the 40s or earlier. Yet little is known about what constitutes normal brain ageing in mid-life. Using a number of neuroimaging and epidemiological techniques this project will scrutinise brain and cognitive ageing in middle-age and their significance.
Mental Health First Aid Training In The Workplace: A Randomized Controlled Trial Of Online And Blended Modes
Funder
National Health and Medical Research Council
Funding Amount
$540,247.00
Summary
This project will evaluate the effects of Mental Health First Aid (MHFA) training, which aims to teach members of the public how to support people they know who are developing a mental health problem or are in a mental health crisis. Training will be offered to Victorian public servants to see whether it changes their knowledge, attitudes and helping behaviour. MHFA training will be delivered either online or as a blend of online with face-to-face teaching, and will be compared with online Red C ....This project will evaluate the effects of Mental Health First Aid (MHFA) training, which aims to teach members of the public how to support people they know who are developing a mental health problem or are in a mental health crisis. Training will be offered to Victorian public servants to see whether it changes their knowledge, attitudes and helping behaviour. MHFA training will be delivered either online or as a blend of online with face-to-face teaching, and will be compared with online Red Cross physical first aid training as a control.Read moreRead less
Long-term Outcome Of Individuals Who Had A First-episode Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$1,344,905.00
Summary
The long-term illness course and outcomes of patients treated for first episode psychosis are poorly understood especially in terms of important domains such as social and vocational functioning, physical health, and quality of life. This treated cohort study of a sample of 786 patients, 15 years after their first episode of psychosis will be one of the longest and largest conducted to date. Results of the study will inform clinical practice and policy development.
Enhanced Treatment For Social Phobia Through The Incorporation Of Attentional Re-training.
Funder
National Health and Medical Research Council
Funding Amount
$465,162.00
Summary
Social phobia is a serious difficulty that can cause tremendous interference in an individual's life. Social phobia can interfere with an individual's social and romantic life, work and study aspirations, and even increase medical and other psychological problems. Psychological programs to help individuals manage their anxiety have been developed and shown to lead to relatively strong positive outcomes. Recent theoretical understanding has suggested that one maintaining factor in social phobia m ....Social phobia is a serious difficulty that can cause tremendous interference in an individual's life. Social phobia can interfere with an individual's social and romantic life, work and study aspirations, and even increase medical and other psychological problems. Psychological programs to help individuals manage their anxiety have been developed and shown to lead to relatively strong positive outcomes. Recent theoretical understanding has suggested that one maintaining factor in social phobia may be these people's tendency to focus onto negative information. In some exciting developments, several researchers have shown that simply training people with social phobia to focus their attention away from negative information, with no other treatment components, can produce a marked change in their fears. Therefore it makes sense that incorporating these methods into current standard treatment packages, may increase their effectiveness. The current study aims to compare the current best practice treatment package for social phobia with a combination of this package plus the recent attention re-training methods. It is expected that incorporating attention re-training into standard treatment with significantly improve its effects.Read moreRead less
Self-help For Depressive Symptoms: Finding Messages Suitable For Population-wide Promotion
Funder
National Health and Medical Research Council
Funding Amount
$161,807.00
Summary
Members of the community often use self-help methods to reduce symptoms of depression. In some cases, these may be effective, but in others they may do more harm than good (e.g. self-medication with nicotine or alcohol). The project aims to find out which self-help methods are most likely to be helpful and are easy for the community to use. These methods can then be promoted in educational campaigns to improve how people cope with symptoms of depression. If people can take action to reduce milde ....Members of the community often use self-help methods to reduce symptoms of depression. In some cases, these may be effective, but in others they may do more harm than good (e.g. self-medication with nicotine or alcohol). The project aims to find out which self-help methods are most likely to be helpful and are easy for the community to use. These methods can then be promoted in educational campaigns to improve how people cope with symptoms of depression. If people can take action to reduce milder levels of depression, this may prevent them from progressing to develop a clinical disorder that needs professional treatment.Read moreRead less
Transdiagnostic Internet Therapy For Internalizing Disorders
Funder
National Health and Medical Research Council
Funding Amount
$687,348.00
Summary
Anxiety and depressive disorders account for 58% of the burden of mental disorders, or 7.5% of the burden of human disease. Internet treatments for the individual disorders are effective but require careful diagnosis. We intend to develop and prove the effectiveness of a transdiagnostic Internet treatment program that will be easily used by primary care clinicians. We will disseminate and evaluate the developed and proven program to general practitioners and psychologists.
Molecular And Cellular Characterisation Of Schizophrenia Associated Dysfunction In MicroRNA Biogenesis
Funder
National Health and Medical Research Council
Funding Amount
$496,205.00
Summary
We have identified substantial changes in the biogenesis of microRNA in schizophrenia. These small non-coding molecules derived from junk DNA, play a significant role in genetic regulation, with each one capable of silencing hundreds of target genes. This has major implications for schizophrenia, which is known to involve substantial changes in gene activity. The project will identify the molecular basis of this alteration in gene silencing, and its biological implications for schizophrenia.