Molecular & Neuropsychological Predictive Markers Of Cognitive Decline.
Funder
National Health and Medical Research Council
Funding Amount
$429,500.00
Summary
Alzheimer's disease (AD) is a major cause of dementia in the elderly. As populations worldwide are living longer the prevalence of AD is predicted to rise markedly and in addition to the huge emotional burden on families the economic implications to the community at large is severe. Thus our aging veteran population and their spouses are particularly vulnerable to this devastating disease. Recent developments in AD research have resulted in a number of therapeutic strategies being undertaken wit ....Alzheimer's disease (AD) is a major cause of dementia in the elderly. As populations worldwide are living longer the prevalence of AD is predicted to rise markedly and in addition to the huge emotional burden on families the economic implications to the community at large is severe. Thus our aging veteran population and their spouses are particularly vulnerable to this devastating disease. Recent developments in AD research have resulted in a number of therapeutic strategies being undertaken with several of these now in phase 2 clinical trials. However for these treatments to be most effective early diagnosis is crucial. Currently, definite diagnosis is restricted to post-mortem examination of the brain for the presence of characteristic neuropathological features. This project proposes to identify individuals at high risk of developing cognitive decline leading to AD by using a battery of biochemical, genetic and neuropsychological markers. This study builds on our earlier work which followed a cohort of memory complainers and demonstrated that subjects in this group have lower cognitive scores and an increased frequency of the genetic risk factor, the e4 allele of apolipoprotein E. Follow up of this well studied cohort with more sensitive and extensive neuropsychological tests together with other genetic and biochemical markers will be important in identifying those risk factors that have positive predictive value for cognitive decline thereby contributing towards enhancing the therapeutic efficacy of current symptomatic and future drugs directed at the cause of AD.Read moreRead less
Models of Knowledge Restructuring. In a world of rapid change, people must frequently adapt cognitive skills to new technologies. This often requires restructuring of knowledge, from simple initial strategies to increasingly complex ways of mastering the task. This is not always easy and people sometimes resist knowledge restructuring. We present a network model of knowledge restructuring that combines attentional processes with error-driven learning. The model accounts for several existing resu ....Models of Knowledge Restructuring. In a world of rapid change, people must frequently adapt cognitive skills to new technologies. This often requires restructuring of knowledge, from simple initial strategies to increasingly complex ways of mastering the task. This is not always easy and people sometimes resist knowledge restructuring. We present a network model of knowledge restructuring that combines attentional processes with error-driven learning. The model accounts for several existing results and makes predictions that guide the proposed research. Three factors will be examined empirically: (1) the role of directing attention to alternative strategies; (2) the imperfection of existing knowledge; and (3) the complexity of alternative strategies.Read moreRead less
Advancing the science of willpower: investigating the mechanisms and processes of self-control. Willpower or 'good' self control is important for success in our academic, occupational, and social lives. This project will use cutting-edge scientific methods to investigate how glucose, the primary fuel for body function, promotes 'good' self-control and stimulates regions in the brain important for self-control.
Testing the Flood Pulse Concept for rivers with variable flow regimes. For floodplain rivers the major unifying conceptual model linking hydrology, biogeochemistry and ecology is the Flood Pulse Concept (FPC). The model is based on rivers that have a seasonally predictable and long duration inundation of floodplain habitats. Recent reviews of the FPC indicate that the model needs to be broadened to describe the function of rivers with more variable flow regimes. This project will test some of th ....Testing the Flood Pulse Concept for rivers with variable flow regimes. For floodplain rivers the major unifying conceptual model linking hydrology, biogeochemistry and ecology is the Flood Pulse Concept (FPC). The model is based on rivers that have a seasonally predictable and long duration inundation of floodplain habitats. Recent reviews of the FPC indicate that the model needs to be broadened to describe the function of rivers with more variable flow regimes. This project will test some of the predictions of the FPC for variable dryland rivers by investigating how food webs in the channels of a floodplain reach respond to flows of different magnitude, seasonal timing and duration.Read moreRead less
Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project ....Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project will also provide valuable data on the nature and extent of the risk feral pigs pose to biodiversity conservation and the environment generally. The outcomes of this research will provide a scientific basis for the development of prioritised strategies for the control of feral pigs in Western Australia.Read moreRead less
Improving Interpreting For Dementia Assessments: The MINDSET Study
Funder
National Health and Medical Research Council
Funding Amount
$271,586.00
Summary
The MINDSET Study aims to improve the quality of communication in an interpreter mediated cognitive assessment for dementia. Working with interpreters, clinicians, culturally and linguistically diverse people with dementia, and their carers we will co-design, trial, and implement national online training targeted at interpreters. This training will enable interpreters to be prepared and confident in performing their role impartially, effectively, and accurately.
Authentic digital representation of creative works in education: addressing the challenges of digitisation and assessment. This project will investigate the digitisation and marking of portfolios for the purposes of summative assessment in the visual arts and design senior secondary school courses. The aim is to enhance moderation, compare between media and course contexts, compare methods of marking, and generally increase the authenticity of the assessment.
Environmental risk assessment of acid sulfate soil formation and pollutant generation in Swan Coastal Plain. The urgency and importance of securing water sources for human use in a sustainable manner is dictated by drying climate and rapid population expansion in Australia. Dropping groundwater levels (less recharge, increased abstraction, enhanced drainage) result in formation of acid sulfate soils in oxidised layers that contain acid-bearing minerals. This project will produce an environmental ....Environmental risk assessment of acid sulfate soil formation and pollutant generation in Swan Coastal Plain. The urgency and importance of securing water sources for human use in a sustainable manner is dictated by drying climate and rapid population expansion in Australia. Dropping groundwater levels (less recharge, increased abstraction, enhanced drainage) result in formation of acid sulfate soils in oxidised layers that contain acid-bearing minerals. This project will produce an environmental risk assessment framework as a basis for (i) educated decisions regarding land development and soil disturbance vs conservation as well as (ii) identifying areas suitable for water abstraction from groundwater resources. This will ensure sustainable use of precious groundwater resources in this drying continent of ours.Read moreRead less
Mining, irrigation, and groundwater: Towards a reliable protocol for assessing the impacts of extraction on groundwater fauna and ecology. Groundwater fluctuations associated with mining and increased irrigation demands, potentially threaten many of Australia's unique groundwater invertebrates (stygofauna) with extinction. Stygofauna represent a hidden store of biodiversity and are thought to have a critical, but poorly understood, role in enhancing groundwater quality. Environmentally sustainab ....Mining, irrigation, and groundwater: Towards a reliable protocol for assessing the impacts of extraction on groundwater fauna and ecology. Groundwater fluctuations associated with mining and increased irrigation demands, potentially threaten many of Australia's unique groundwater invertebrates (stygofauna) with extinction. Stygofauna represent a hidden store of biodiversity and are thought to have a critical, but poorly understood, role in enhancing groundwater quality. Environmentally sustainable development of groundwater resources is hampered by a dearth of information on the ecological needs of stygofauna and how they respond to human-induced change. Using field and laboratory experiments, we aim to determine how water table fluctuations threaten stygofauna. From our results we will develop sampling and management protocols to monitor and protect stygofauna communities.Read moreRead less
Exposure To Diesel Exhaust And Lung Cancer Risk In Australia
Funder
National Health and Medical Research Council
Funding Amount
$581,519.00
Summary
Exposure to diesel exhaust increases the risk of lung cancer. One in five Australians is exposed to diesel exhaust in the workplace. This project will provide an exposure-response relation between diesel exhaust and lung cancer based on Australia-specific data. We will also estimate the number of lung cancer cases due to diesel exhaust exposure in Australia. We will do this by studying all miners in WA in the last 15 years, by linking several databases that are available in WA.