Quantifying The Effectiveness Of Pertussis Vaccine In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$448,703.00
Summary
Pertussis is the most poorly controlled vaccine preventable disease in Australia. Childhood pertussis is a well-known public health problem but adult pertussis is also common and has a significant burden on the health system, especially in adults over 65 years. Pertussis vaccines for adults are currently not funded by our national immunisation program. This project will provide vital data to inform whether pertussis vaccination is cost-effective in older Australian adults.
Understanding Causes Of The Rising Incidence Of Thyroid Cancer – What Can Mutations In The BRAF Oncogene Tell Us About Causes And Diagnostic Pathways For Thyroid Cancer?
Funder
National Health and Medical Research Council
Funding Amount
$610,222.00
Summary
The occurrence of thyroid cancer has increased rapidly over the last 25 years but the cause is unknown. The increase may reflect ‘over-diagnosis’ of less harmful cancers or greater exposure to causes of this cancer. Evidence suggests that a gene mutation (BRAF) in thyroid cancers is important in understanding the drivers of the increase. This study will examine the increase in thyroid cancer by investigating causes and diagnostic pathways considering the presence or absence of BRAF mutations.
Methylation As A Risk And Prognostic Factor For Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$594,913.00
Summary
DNA methylation is a process playing critical roles throughout life by altering the expression of genes. This study aims to investigate the potential use of methylation as marker of risk and early diagnosis of breast cancer in women with no clinical evidence of disease and marker of prognosis and response to treatment in breast cancer cases.
The Epidemiology Of Multiple Myeloma In Australia (EMMA)
Funder
National Health and Medical Research Council
Funding Amount
$1,525,729.00
Summary
In Australia, over 1,000 people are diagnosed with multiple myeloma annually. Our proposal aims to identify possible environmental and genetic causes of this serious disease. People diagnosed with myeloma, and their family members, will provide detailed personal and family histories. We plan to investigate the role of sun exposure, body size and obesity, dietary factors and pesticides as well as a large range of genetic variants. The 5-year study will be conducted in Victoria and NSW.
Cancer Epidemiology In High-risk Populations And Complex Cancers
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
My research program aims to better understand the causes of cancer and factors that influence outcomes after cancer diagnosis. It employs classical and innovative cancer epidemiology and includes large-scale studies of cancer incidence, survival and risk factors in people with immune dysfunction. It also includes studies of lymphoid malignancies and ‘cancer of unknown primary’ origin. The research program aims to build an evidence base for interventions that will reduce the burden of cancer nati ....My research program aims to better understand the causes of cancer and factors that influence outcomes after cancer diagnosis. It employs classical and innovative cancer epidemiology and includes large-scale studies of cancer incidence, survival and risk factors in people with immune dysfunction. It also includes studies of lymphoid malignancies and ‘cancer of unknown primary’ origin. The research program aims to build an evidence base for interventions that will reduce the burden of cancer nationally and internationally.Read moreRead less
A Case Control Study Of Risk Factors For Aggressive Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,592,353.00
Summary
Although most prostate cancers are not fatal, some develop into an aggressive form that is likely to progress and kill. How this happens and how to prevent these cancers, is not well understood. The study will examine the lives of men with aggressive prostate cancer, from the time of conception to adulthood, their family history and genetic characteristics to identify the role of life patterns and genes in the development of these cancers, seeking a basis for their prevention .