Motility as a means to understand prokaryotic function in the biosphere. Bacterial processes are crucial to the environment, industry and technology of Australia. This work will open a new area of research to expand our understanding of how bacteria behave and function. This will lay the foundation for improved environmental management and resource utilisation in the critical areas of groundwater purification, coral infections, fisheries yields, petroleum remediation and bioenergy generation. Th ....Motility as a means to understand prokaryotic function in the biosphere. Bacterial processes are crucial to the environment, industry and technology of Australia. This work will open a new area of research to expand our understanding of how bacteria behave and function. This will lay the foundation for improved environmental management and resource utilisation in the critical areas of groundwater purification, coral infections, fisheries yields, petroleum remediation and bioenergy generation. This proposal will train over a dozen new scientists in these crucial areas and bring leading international scientists to Australia in the areas of bioenergy production, microfluidics, advanced microscopy and bioengineering.Read moreRead less
Enhancement of monopartite geminivirus pathogenicity by satellite DNA beta encoded betaC1 protein: the role of host factors. Australian incursions of geminiviruses are uncontrollable due to their unique mode of spread by whiteflies. The first incursion in Darwin in 1970 has spread to Far Northern Queensland. The second in SE Queensland in 2006 is estimated to cause $500 million loss to horticulture. Our $2 billion cotton industry is threatened by cotton leaf curl diseases from South Asia, where ....Enhancement of monopartite geminivirus pathogenicity by satellite DNA beta encoded betaC1 protein: the role of host factors. Australian incursions of geminiviruses are uncontrollable due to their unique mode of spread by whiteflies. The first incursion in Darwin in 1970 has spread to Far Northern Queensland. The second in SE Queensland in 2006 is estimated to cause $500 million loss to horticulture. Our $2 billion cotton industry is threatened by cotton leaf curl diseases from South Asia, where DNA beta enhances virus replication and disease severity. DNA beta has the potential to enter Australia with several different geminiviruses and to spread into others by co-infection, which requires research on detection and pathogenesis of DNA beta.Read moreRead less
Role of plant host factors in the replication and pathogenesis of Tomato leaf curl virus (TLCV). Geminivirus infection is an emerging problem in the Australian tomato growing industry which is currently worth ca.A$200m annually. Knowledge gained from this research will have direct benefit in safeguarding this industry by providing an insight into geminivirus replication and identifying molecular targets for virus control. More generally, the technology developed through this study will contribu ....Role of plant host factors in the replication and pathogenesis of Tomato leaf curl virus (TLCV). Geminivirus infection is an emerging problem in the Australian tomato growing industry which is currently worth ca.A$200m annually. Knowledge gained from this research will have direct benefit in safeguarding this industry by providing an insight into geminivirus replication and identifying molecular targets for virus control. More generally, the technology developed through this study will contribute to our basic understanding of virus replication in plants with a view to controlling virus diseases by direct molecular intervention with specifically engineered tools. We foresee potential industrial applications. Read moreRead less
Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in ....Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in the wild, leaving vaccination as the only realistic option. This is valuable for both wild and captive koalas; zoos report high animal losses due to KoRV-associated lymphoma. The main outcome will be a KoRV vaccine which can be combined with a Chlamydia vaccine which is being developed in parallel.Read moreRead less