Mechanism of glutamate transport from experimental and simulation studies. Glutamate transporters play key roles in shaping the electrical signaling in the brain. Under conditions of stress or after a stroke, glutamate transporter function is impaired, which can lead to excessive levels of glutamate, cell death and impaired brain function. The project will help to decipher the operation of glutamate transporters at a molecular level and provide greater understanding of how glutamate levels are c ....Mechanism of glutamate transport from experimental and simulation studies. Glutamate transporters play key roles in shaping the electrical signaling in the brain. Under conditions of stress or after a stroke, glutamate transporter function is impaired, which can lead to excessive levels of glutamate, cell death and impaired brain function. The project will help to decipher the operation of glutamate transporters at a molecular level and provide greater understanding of how glutamate levels are controlled, which is vital for developing better treatments for neurological disorders such as stroke. The project will also provide research training in experimental/computational molecular biology, which is a rapidly growing field underpinning the biotechnological and pharmaceutical industries. Read moreRead less
Special Research Initiatives - Grant ID: SR0354794
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Astronomy. Australian e-Astronomy will provide a pre-eminent example of an integrated e-Science program. The Australian e-Astronomy Research Network will build on and extend the LIEF-funded national program to participate in the International Virtual Observatory. The network includes key members of most Australian astronomy research groups, a strong group representing grid research and advanced computing partnerships and an extensive group of international experts. The network dev ....Australian e-Astronomy. Australian e-Astronomy will provide a pre-eminent example of an integrated e-Science program. The Australian e-Astronomy Research Network will build on and extend the LIEF-funded national program to participate in the International Virtual Observatory. The network includes key members of most Australian astronomy research groups, a strong group representing grid research and advanced computing partnerships and an extensive group of international experts. The network developed by Australian e-Astronomy will service the entire Australian astronomical research community (eg theory codes, databases, software telescopes) and provide new programs for postgraduate research training.Read moreRead less
Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operati ....Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operation and seeking cures for diseases caused by their malfunction. This project aims to develop accurate ion-protein-water interactions for permeation models based on stochastic and molecular dynamics simulations using both classical and quantum mechanical methods.Read moreRead less
Quantum mechanical and dynamical investigation of ion channels. Many genetic diseases result from mutations in the genes that transcribe the channel proteins. Ion channels are also primary targets for development of therapeutic drugs for many ailments. Development of proper simulation tools is essential for a molecular-level understanding of their operation, which will be very helpful in finding treatments for genetic diseases as well as new drugs that target ion channels. Another aim of the p ....Quantum mechanical and dynamical investigation of ion channels. Many genetic diseases result from mutations in the genes that transcribe the channel proteins. Ion channels are also primary targets for development of therapeutic drugs for many ailments. Development of proper simulation tools is essential for a molecular-level understanding of their operation, which will be very helpful in finding treatments for genetic diseases as well as new drugs that target ion channels. Another aim of the project is to provide research training in computational biology. Research in this area is rapidly growing elsewhere but it has been rather neglected in Australia, and there is a shortage of researchers with such skills at present.Read moreRead less
Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of internation ....Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of international collaborations with Europe and Japan; (iii) outcomes will ultimately impact on improved medical bionics and future interfaces between brain activity and machines or computers; and (iv) commercialization and technology transfer opportunities, via the transfer of results to biologically inspired engineering.Read moreRead less
Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales ....Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales with molecular dynamics at small distances and shorter times. Applications to both membrane proteins (blocking of ion channels by toxins and drugs) and globular proteins (ligand binding to receptors and protein association) will be considered.Read moreRead less
Silk Fibroin Optofluidic Chips. Unlike any other material, even any other biologically occurring material, silk is unique in being very transparent, able to be shaped on a very small scale and can keep natural chemicals like proteins and enzymes active. This project will use silk to make optical devices and sensors. Optics made from silk will have all these properties, which means that they can be used as sensors and devices in biochemistry applications that have never been possible before. Thes ....Silk Fibroin Optofluidic Chips. Unlike any other material, even any other biologically occurring material, silk is unique in being very transparent, able to be shaped on a very small scale and can keep natural chemicals like proteins and enzymes active. This project will use silk to make optical devices and sensors. Optics made from silk will have all these properties, which means that they can be used as sensors and devices in biochemistry applications that have never been possible before. These cost-effective devices will have the potential to enhance healthcare, emergency medicine and assist early medical diagnosis.Read moreRead less
Statistical Mechanics of Classical Glasses. Glasses and ceramics can possess a combination of properties not available in other materials and thus they are of technological importance with rapidly developing applications. However a fundamental theoretical basis for describing these systems has been missing. The reason for this is that glasses are not in thermodynamic equilibrium, so the standard tools of equilibrium statistical mechanics cannot be rigorously applied . This project will make an i ....Statistical Mechanics of Classical Glasses. Glasses and ceramics can possess a combination of properties not available in other materials and thus they are of technological importance with rapidly developing applications. However a fundamental theoretical basis for describing these systems has been missing. The reason for this is that glasses are not in thermodynamic equilibrium, so the standard tools of equilibrium statistical mechanics cannot be rigorously applied . This project will make an important contribution towards building a strong local knowledge base by addressing the problem of understanding the glassy state. The knowledge base can then serve as a springboard for possible high tech applications in materials science and engineering.Read moreRead less
Linear Dynamical Quantum Networks: Synthesis and Control. Australia is recognized as a leader in the international race to develop quantum technologies of the future. This project will strengthen Australia's profile in quantum technology engineering by developing a new theory for building arbitrary complex linear quantum mechanical control systems for control tasks in quantum technology, and presenting new control system design tools to support high performance quantum communication systems. The ....Linear Dynamical Quantum Networks: Synthesis and Control. Australia is recognized as a leader in the international race to develop quantum technologies of the future. This project will strengthen Australia's profile in quantum technology engineering by developing a new theory for building arbitrary complex linear quantum mechanical control systems for control tasks in quantum technology, and presenting new control system design tools to support high performance quantum communication systems. The project outcomes together with advances in experimental physics are anticipated to play an important role in the long term as enablers of viable quantum technologies that can provide new commercial opportunities for Australian hi-tech industries to benefit Australia's economy in the future.Read moreRead less
Miniaturised Adiabatic Light Processing Devices. The project will develop, model and analyse a range of miniaturised light-processing devices for optical communications applications that rely soley on their geometrical design for their optical functionality. Such devices are less complex than devices that rely on other physical phenomena for their operation, such as interference, resonance or grating phenomena. They have potential application to a wide range of applications including optical tel ....Miniaturised Adiabatic Light Processing Devices. The project will develop, model and analyse a range of miniaturised light-processing devices for optical communications applications that rely soley on their geometrical design for their optical functionality. Such devices are less complex than devices that rely on other physical phenomena for their operation, such as interference, resonance or grating phenomena. They have potential application to a wide range of applications including optical telecommunications, optical sensing and biophotonics. The major outcome will be a range of novel devices that are very compact, have very low optical power loss and process light signals in ways that either cannot be readily achieved by other approaches or are simpler than other approaches.Read moreRead less