Central pathways regulating visceral pain. This project aims to investigate the neural pathways within the spinal cord and brain processing colorectal pain perception. The project aims to identify the spinal cord neurons relaying colorectal signalling into the brain and the influence of descending modulation from the brainstem upon these pathways. The outcomes will greatly benefit fundamental understanding of the central pathways processing visceral pain.
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347607
Funder
Australian Research Council
Funding Amount
$306,000.00
Summary
FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged ex ....FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged expertise as well as priority within their respective institutions. In addition, it will facilitate wide-ranging collaborative arrangements to further develop and exploit this research area.Read moreRead less
Hierarchical information processing in the primate visual cortex. This project aims to understand how visual information is transformed across hierarchical levels in the brain. Neuroscientists have long recognised that the visual cortex can be conceptualised as a hierarchical processing network. This became apparent when learning algorithms based on hierarchical networks ("deep learning") changed artificial intelligence. This project will combine high-throughput electrophysiology with analytical ....Hierarchical information processing in the primate visual cortex. This project aims to understand how visual information is transformed across hierarchical levels in the brain. Neuroscientists have long recognised that the visual cortex can be conceptualised as a hierarchical processing network. This became apparent when learning algorithms based on hierarchical networks ("deep learning") changed artificial intelligence. This project will combine high-throughput electrophysiology with analytical tools adopted from deep learning. By explaining the physiological properties of higher-level neurons in terms of hierarchical networks, the project expects to address long standing questions in neuroscience, and provide insights on biological hierarchical computation.Read moreRead less
Novel computational tools for the analysis of sympathetic nervous system activity. This project will investigate electrical signals from the heart, resulting in novel tools for the assessment of sympathetic nervous system activity. The findings will contribute to advancing Australia's international leading position in health technology and improve community health.
Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
Left of centre: Attentional distortions in the mental representation of space in healthy and clinical populations. Stroke patients cost the Australian economy $1.3bn pa in addition to their social burden, but effective diagnosis and rehabilitation is impeded by a lack of fundamental research into the cognitive and neural mechanisms that underlie attentional disorders. Our research will provide significant new insights into how the brain deploys attention in external and imagined space and will l ....Left of centre: Attentional distortions in the mental representation of space in healthy and clinical populations. Stroke patients cost the Australian economy $1.3bn pa in addition to their social burden, but effective diagnosis and rehabilitation is impeded by a lack of fundamental research into the cognitive and neural mechanisms that underlie attentional disorders. Our research will provide significant new insights into how the brain deploys attention in external and imagined space and will lead to more effective management and treatment of stroke victims. Our new test of attentional disorders is independent of a patient's inability to see or move and will enable more effective diagnosis. Our research provides the fundamental knowledge base for our discipline and is vital for developing the next generation of Australia's cognitive neuroscientists. Read moreRead less
ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environme ....ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environments. EII will address 3 tightly coupled research themes: Ability to interoperate across existing heterogenous platforms & applications; Efficient processing of very large data sets; Technology adoption & impact. Generic results will be applicable to e-science and large business information systems installations.Read moreRead less
Fault detection and identification in nonlinear complex systems. Complex systems usually comprise a large number of inter-dependent subsystems linked together to perform a certain task. Examples of such systems are power systems, irrigation systems, air traffic control systems, to name a few. Such systems are subject to component failure or malfunction. Total failure can cause an unacceptable financial losses and/or danger to personnel. It is therefore extremely essential, from economic and safe ....Fault detection and identification in nonlinear complex systems. Complex systems usually comprise a large number of inter-dependent subsystems linked together to perform a certain task. Examples of such systems are power systems, irrigation systems, air traffic control systems, to name a few. Such systems are subject to component failure or malfunction. Total failure can cause an unacceptable financial losses and/or danger to personnel. It is therefore extremely essential, from economic and safety view points, that a way be found to ensure reliable and viable operation of complex plants. A first step in achieving this goal is to detect faults on-line and in real-time when they occur and identify their location and characteristics, which is the aim of this project.Read moreRead less
Designing the next generation of geosynthetic liner systems . The project aims to improve the effectiveness of geosynthetic liner systems to contain emerging contaminants such as per-and poly-fluoroalkyl substances (PFASs) for better protection of Australian groundwater resources. The project expects to experimentally validate theory to improve predictive models for performance of geosynthetic liner systems. Expected outcomes include new and updated design guidelines for effective environmental ....Designing the next generation of geosynthetic liner systems . The project aims to improve the effectiveness of geosynthetic liner systems to contain emerging contaminants such as per-and poly-fluoroalkyl substances (PFASs) for better protection of Australian groundwater resources. The project expects to experimentally validate theory to improve predictive models for performance of geosynthetic liner systems. Expected outcomes include new and updated design guidelines for effective environmental protection against PFASs and establishment of new approaches for predicting functional containment lifetimes of liner systems. These outcomes are expected to benefit the waste and remediation industries by influencing next-generation design regulations to ensure long-term environmental protection from PFAS.Read moreRead less