The Role Of Corticothalamic Feedback On The Response Dynamics Of Thalamic Neurons
Funder
National Health and Medical Research Council
Funding Amount
$351,852.00
Summary
A fundamental question in neuroscience is how the brain selectively processes sensory information to generate a reliable representation of the world. Positioned in the centre of the brain, the thalamus plays a key role in sensory processing. This project investigates how the interaction between thalamus and cortex shapes the selection and gating of sensory information. This is a fundamental question in basic neuroscience with the potential to increase our knowledge about attentional deficits.
Peripheral and central mechanisms of sensory coding and integration. The research described in this proposal seeks to provide generic answers to fundamental questions about sensory processes, the nature of perceptual experience, and how these are subserved by the nervous system. The study of inter-sensory interactions in perception has the potential to be incorporated into the development of virtual reality-type computer-based technologies. The neurophysiology research will provide basic informa ....Peripheral and central mechanisms of sensory coding and integration. The research described in this proposal seeks to provide generic answers to fundamental questions about sensory processes, the nature of perceptual experience, and how these are subserved by the nervous system. The study of inter-sensory interactions in perception has the potential to be incorporated into the development of virtual reality-type computer-based technologies. The neurophysiology research will provide basic information that has the potential to deepen our understanding, and even enhance possible treatment, of neurological conditions that involve sensory systems.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453630
Funder
Australian Research Council
Funding Amount
$274,692.00
Summary
High-Speed Confocal Microscope Live Cell Recording System. The high-speed confocal microscope live cell recording system we are establishing represents new generation equipment. It allows quality imaging of selected subcellular regions of live cells combined with simultaneous electrophysiological recording at rates and sensitivity hitherto not possible. This equipment provides a window of opportunity for major research advances in that it allows real-time two and three-dimensional imaging of fun ....High-Speed Confocal Microscope Live Cell Recording System. The high-speed confocal microscope live cell recording system we are establishing represents new generation equipment. It allows quality imaging of selected subcellular regions of live cells combined with simultaneous electrophysiological recording at rates and sensitivity hitherto not possible. This equipment provides a window of opportunity for major research advances in that it allows real-time two and three-dimensional imaging of fundamental cellular activities that previously could not be viewed. It will allow major advances in priority health-related research and will provide an ideal research tool to introduce young scientists and students to cutting edge research.Read moreRead less
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
Special Research Initiatives - Grant ID: SR0354729
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a h ....Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a higher order of coordination and collaboration in research into ICT applications.
The feasibility study proposed will engage key stakeholders, refine research goals and investigate linkage mechanisms to improve Australia's ICT research and its contribution to economic and social well-being.
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Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
A unified model of amino acid homeostasis. This project aims to develop a unified model of amino acid homeostasis in mammalian cells and apply it to brain cells. The model will be underpinned by a mathematical algorithm that allows predicting amino acid levels in the cytosol based on fundamental parameters such as transport and metabolism. This project should provide the significant benefit of enabling the prediction of essential functions such as cell growth and survival.
Special Research Initiatives - Grant ID: SR0354794
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Astronomy. Australian e-Astronomy will provide a pre-eminent example of an integrated e-Science program. The Australian e-Astronomy Research Network will build on and extend the LIEF-funded national program to participate in the International Virtual Observatory. The network includes key members of most Australian astronomy research groups, a strong group representing grid research and advanced computing partnerships and an extensive group of international experts. The network dev ....Australian e-Astronomy. Australian e-Astronomy will provide a pre-eminent example of an integrated e-Science program. The Australian e-Astronomy Research Network will build on and extend the LIEF-funded national program to participate in the International Virtual Observatory. The network includes key members of most Australian astronomy research groups, a strong group representing grid research and advanced computing partnerships and an extensive group of international experts. The network developed by Australian e-Astronomy will service the entire Australian astronomical research community (eg theory codes, databases, software telescopes) and provide new programs for postgraduate research training.Read moreRead less