The role of Roquin in microRNA function and decay. The aim of this study is to understand how microRNAs (newly discovered genetic components that control cell growth and survival) function and are regulated. The expected discoveries will help understand how common cancers including breast cancer and autoimmune diseases emerge, and will help develop cutting edge genetic technologies.
HEN1 is a regulator of piRNA metabolism, transcriptional regulation and mammalian male fertility. This project is to define the biochemistry of a previously uncharacterized protein in male fertility using a unique mouse model and innovative DNA and protein technologies. This project will define a novel, and essential, pathway for male fertility and may ultimately have relevance to the maintenance of health or improving fertility.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100111
Funder
Australian Research Council
Funding Amount
$475,000.00
Summary
Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations. Expanding the genomic frontier from species to strains and individuals to populations: The Ramaciotti Centre for Gene Function Analysis, a consortium of five universities, provides a large number of genomics and transcriptomics analyses. This project will establish an Ion Proton semiconductor-based sequencer and iScan platform to facilitate research breakthroughs in genomics, epigenomics, transcriptomics, an ....Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations. Expanding the genomic frontier from species to strains and individuals to populations: The Ramaciotti Centre for Gene Function Analysis, a consortium of five universities, provides a large number of genomics and transcriptomics analyses. This project will establish an Ion Proton semiconductor-based sequencer and iScan platform to facilitate research breakthroughs in genomics, epigenomics, transcriptomics, and SNP analysis. Cell screening technology will also be established to allow the rapid analysis of cells of interest, prior to genomic / transcriptomic analysis. The increased data output, and concomitant reduction in analysis cost on the new platforms, will expand the genomics frontier, allowing researchers to fully analyse many strains from a single-celled species or many individuals from a population.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100025
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
A high-throughput screening and sequencing facility for single cell genomics. Genomics has revolutionised biology, but for most microorganisms this revolution has not arrived because very few can be grown in pure culture. The single cell genomics facility will address this major bottleneck by allowing as little as a single cell in a clinical or environmental setting to be sequenced thereby accelerating new discoveries and outcomes.
TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. ....TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. The research team unites international industry, the Australian Plant Phenomics Facility, and university statistical geneticists. TraitCapture software will use open standards applicable to both controlled and field environments enabling plant breeders to pre-select adaptive traits to increase crop productivity under environmental stress.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100234
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Enhancement of South Australian high-performance computing facilities. These facilities will enable the efficient use of high-performance computing and will more than double the capability provided by eResearch SA for South Australian researchers. They will support large-scale applications, running over many processors in parallel (high-performance computing) or large numbers of single processors (high-throughput computing).