Subcellular recruitment of a RhoA ubiquitination complex by Rnd proteins. This study addresses a novel molecular mechanism through which members of the Rnd family of GTP-binding proteins regulate the morphology and migration of immature nerve cells of the developing nervous system. This study has broad implications for the understanding of cell migration during embryo development, as well as in health and disease.
Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source ....Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source of stem cells. The experiments conducted in this study will provide strategies to improve the efficacy of stem cell transplantation into the damaged CNS as well as developing the use of autologous bone marrow stem cells for repair. Outcomes will be improved transplant methodologies and expertise for the bio-technology industry. Read moreRead less
Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to ....Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to investigate a broad range of cognitive and communication functions. Benefits will include potential technologies and algorithms to assist listening (in devices such as hearing aids), language development and reading.Read moreRead less
The critical role of kisspeptin/neurokinin/dynorphin (KNDy) neurons in gonadotropin releasing hormone (GnRH) release. The brain controls fertility through the secretion of its primary stimulatory factor, gonadotropin releasing hormone (GnRH). Brain cells producing three key peptide hormones, kisspeptin, neurokin B and dynorphin (termed KNDy cells) are vital for the control of GnRH. This project will detail the role of KNDy cells in puberty and reproduction.
Using magnetic nanotechnology to aid recovery from neurotrauma. Nanotechnology is an exciting new field that holds great promise to solve challenging health issues including neurotrauma associated with brain and spinal cord injury. Current methods to deliver drugs and stimulate tissue repair after neurotrauma do not work effectively and new approaches are urgently need. The recently established research team brings together expertise in nanotechnology and neuroscience to develop new, safe ways t ....Using magnetic nanotechnology to aid recovery from neurotrauma. Nanotechnology is an exciting new field that holds great promise to solve challenging health issues including neurotrauma associated with brain and spinal cord injury. Current methods to deliver drugs and stimulate tissue repair after neurotrauma do not work effectively and new approaches are urgently need. The recently established research team brings together expertise in nanotechnology and neuroscience to develop new, safe ways to deliver drugs and stimulate tissue repair after neurotrauma, and provide quality research training. Specifically designed nanomaterials will deliver drugs slowly over time and act as scaffolds to stop cells dying and stimulate them to restore broken connections and work again. Read moreRead less
Targeted enzymatic treatment of the injured central nervous system using innovative nanotechnology. Nanotechnology and other frontier areas in science have exciting potential to solve major challenges of the 21st century, including health. The proposed research provides the real possibility of discovering ways to alleviate the many complex problems associated with neurotrauma following, for example, brain and spinal cord injury. Current delivery of therapeutics do not work effectively and new ap ....Targeted enzymatic treatment of the injured central nervous system using innovative nanotechnology. Nanotechnology and other frontier areas in science have exciting potential to solve major challenges of the 21st century, including health. The proposed research provides the real possibility of discovering ways to alleviate the many complex problems associated with neurotrauma following, for example, brain and spinal cord injury. Current delivery of therapeutics do not work effectively and new approaches are urgently needed. The recently established powerful multidisciplinary research team combines expertise in nanotechnology, glycobiology and neuroscience to develop novel, safe ways to deliver therapeutic enzymes over biological time-courses. We aim to make broken connections work again, while providing quality research training.Read moreRead less
Broad spectrum nanomedicine for Meningitis treatment. Brain inflammatory diseases are among the top ten infectious causes of death. The project aims to provide Australian doctors with a superior alternative of treating infections that do not respond to conventional antibiotics. The nanomedicine developed will reduce the burden of hospital and boost Australia economy in the biomedical sector.
How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at ....How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at improving educational outcomes or counteracting age-related memory decline. Potential future benefits include facilitating the development of drugs to circumvent memory loss resulting from brain diseases, and improving the design of neuromorphic hardware for computing.Read moreRead less
Atypical cognition in autism: preference for nonverbal coding and impaired connectivity? This project will investigate whether individuals with autism prefer to think 'in pictures' rather than use words, and whether their thinking shows evidence of limited connections across brain regions. Establishing either characteristic for autism would provide important direction in improving diagnosis and intervention for affected children.
A shared genetic basis for development of the nervous system and glands. Fruit flies possess strikingly similar versions of the genes that promote normal human development. The list of systems with genetic parallels between humans and fruit flies includes the respiratory and circulatory systems; cardiovascular development and disease; sleep; learning and memory; brain development and disease; taste, sight, smell and hearing. This project could add at least some human glands, the mucous-secreting ....A shared genetic basis for development of the nervous system and glands. Fruit flies possess strikingly similar versions of the genes that promote normal human development. The list of systems with genetic parallels between humans and fruit flies includes the respiratory and circulatory systems; cardiovascular development and disease; sleep; learning and memory; brain development and disease; taste, sight, smell and hearing. This project could add at least some human glands, the mucous-secreting goblet cells, to this list, providing a potentially useful model for studying human diseases associated with gland dysfunction. Read moreRead less