Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less
Determining how calcium regulates mitochondrial function in models of cardiomyopathy. Heart failure is the leading cause of death in Australia. This project will determine the mechanisms by which the failing heart is associated with disorganisation of the cell and poor energy supply so that interventions aimed at reducing the development of heart failure can be developed.
The lipidomics of cell fate. This project aims to dissect the roles of lipids in cell fate. The study of lipids, or lipidomics, is an emerging and exciting area of biological science. The fundamental roles of lipids in development remain vastly understudied. This project will look at reprogramming of somatic cells into stem cells, their pluripotency and differentiation. This will be complemented with studies in the zebrafish, which permits the direct study of cell fate in vivo. This approach is ....The lipidomics of cell fate. This project aims to dissect the roles of lipids in cell fate. The study of lipids, or lipidomics, is an emerging and exciting area of biological science. The fundamental roles of lipids in development remain vastly understudied. This project will look at reprogramming of somatic cells into stem cells, their pluripotency and differentiation. This will be complemented with studies in the zebrafish, which permits the direct study of cell fate in vivo. This approach is a powerful way to unlock major events involved in development and to unmask the roles of lipids in these fundamental mechanisms.Read moreRead less
Real-Time Searches for Gravitational Waves and Identification of Their Radio and Optical Counterparts. The proposed project will directly address the national research priority in development of frontier technologies, directly involve Australians in frontier work in gravitational wave astronomy that will result in break-through sciences and improve the chance of the international Square-Kilometer-Array project being sited at Australia. In addition, it will foster a close collaboration of top int ....Real-Time Searches for Gravitational Waves and Identification of Their Radio and Optical Counterparts. The proposed project will directly address the national research priority in development of frontier technologies, directly involve Australians in frontier work in gravitational wave astronomy that will result in break-through sciences and improve the chance of the international Square-Kilometer-Array project being sited at Australia. In addition, it will foster a close collaboration of top international researchers with an Australian team. The research at The University of Western Australia will attract students from around the world and serve to educate and inspire young people in Australia.Read moreRead less
Heritage diplomacy and One Belt One Road. This project aims to address China’s One Belt One Road (OBOR) initiative, utilising the concept of heritage diplomacy to interpret the role culture plays in shaping trade and diplomatic relations. This project expects to develop new knowledge about 21st Century diplomacy and the political drivers of heritage preservation today. Expected outcomes of the project include collaborations with OBOR think tanks and universities in Australia, China and Central A ....Heritage diplomacy and One Belt One Road. This project aims to address China’s One Belt One Road (OBOR) initiative, utilising the concept of heritage diplomacy to interpret the role culture plays in shaping trade and diplomatic relations. This project expects to develop new knowledge about 21st Century diplomacy and the political drivers of heritage preservation today. Expected outcomes of the project include collaborations with OBOR think tanks and universities in Australia, China and Central Asia, and an open access-mapping database based on international heritage documentation standards. This should significantly assist Australian and heritage international agencies understand the large-scale forces and pressures that shape their future conservation policies in the region.Read moreRead less
Home ownership and housing wealth: ageing and intergenerational pathways. This project plans to fill major research gaps by delivering new evidence on the drivers of intergenerational housing wealth inequality. It aims to generate new knowledge on the ways in which baby boomers manage housing wealth, and shed light on their experiences of using wealth transfers to improve their children’s housing outcomes. The project offers innovative cross-national analyses that should produce internationally ....Home ownership and housing wealth: ageing and intergenerational pathways. This project plans to fill major research gaps by delivering new evidence on the drivers of intergenerational housing wealth inequality. It aims to generate new knowledge on the ways in which baby boomers manage housing wealth, and shed light on their experiences of using wealth transfers to improve their children’s housing outcomes. The project offers innovative cross-national analyses that should produce internationally relevant findings and foster collaborations on a significant scale. It is expected to provide major national benefits by promoting a shift away from short-term policy planning that unintentionally set generations against each other towards a more holistic policy perspective that meet the needs of co-existing generations.Read moreRead less
Developmental functions of oxygen and redox cues in plants. This project aims to transform our understanding of the regulation of meristem functions, with a central hypothesis that plant cell quiescence (repressed cell division) is governed by oxygen and oxidation/reduction (redox)-dependent cues. Meristems are the growing tips of plants, and thus the fundamental unit of plant growth and productivity. This project will develop new knowledge of how plants integrate changes in the environment to r ....Developmental functions of oxygen and redox cues in plants. This project aims to transform our understanding of the regulation of meristem functions, with a central hypothesis that plant cell quiescence (repressed cell division) is governed by oxygen and oxidation/reduction (redox)-dependent cues. Meristems are the growing tips of plants, and thus the fundamental unit of plant growth and productivity. This project will develop new knowledge of how plants integrate changes in the environment to regulate meristem activity. This project will define new paradigms of how oxygen and redox status interact with energy and other cues to regulate decisions to grow or quiesce. This will underpin the development of new strategies to optimise crop management and productivity, improve the efficiency of inputs, and reduce the risk of decision making in crop production.Read moreRead less
Ecosystem response to climate and anthropogenic disturbances: implications for greenhouse gas emissions and nutrient cycling. Humanity is challenged with climate change, greenhouse gas emissions, declining fertiliser reserves and a need to feed the world's growing population. This project will result in greater understanding of how ecosystems can respond to these challenges and provide a framework to help Australia manage its agricultural and natural reserves.
Making social cohesion ecocentric through Indigenous language and song . This project expects to develop Indigenous language and song in ways that reframe and Indigenise social cohesion, expanding it from a human-centric policy goal to include connections with everything in Country. Designing and implementing an unprecedented and sustained program of Noongar language and song revitalisation in the south of Western Australia across community, schools, and the performing arts, it should advance th ....Making social cohesion ecocentric through Indigenous language and song . This project expects to develop Indigenous language and song in ways that reframe and Indigenise social cohesion, expanding it from a human-centric policy goal to include connections with everything in Country. Designing and implementing an unprecedented and sustained program of Noongar language and song revitalisation in the south of Western Australia across community, schools, and the performing arts, it should advance the potential for Indigenous expressive culture to nourish reciprocal social and ecological relationships that are adaptable to environmental change. Emerging from a hotspot for biodiversity and global warming, it intends to explore how Indigenous creative responses can focus and spur action on pressing global challenges.
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