Revealing how the human brain coordinates body movements for applications in health and technology. This project will extend the basic understanding about how the brain controls the movements of our bodies, and how it changes to allow us to adapt and refine our movements. This project will generate information that is critical for applications in the fields of health (e.g. rehabilitation) and technology (e.g. human-machine interfaces).
Chronic pain and functional impairment following traumatic injury: an investigation into the impact of compensation status and experience. This project will enhance understanding of the impact of the psychosocial factors and the compensation process on recovery from traumatic injury. The project will generate new resources (screening and referral guidelines; educational materials) to improve decision making consistency, client experience, and recovery from road trauma.
Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of m ....Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of medical conditions, from spinal cord injury through to epilepsy. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
Toll-like receptors in infectious and inflammatory diseases: the double-edged sword of innate immunity. The innate immune system is the first line of defence against invading microorganisms. This project will explore the role of specific innate immune genes in the control of infections and the development of inflammatory diseases.
Structural design of third generation biomaterials. This project will design third generation biomaterials for heart valves, cartilage and bones that guide the formation of new tissue whilst being dissolved inside the human body. As a result, it is anticipated that painful and costly revision surgery will become obsolete. Major benefits will be achieved in paediatric health as implants will have the ability to grow with the child.
Crosstalk between breast cancer cells and the microenvironment to promote metastasis. Breast cancer spread (metastasis) to distant tissues is usually fatal. It is now clear that cross-talk between cancer cells and other normal cells is essential for metastasis and previous studies have discovered two key mechanisms: tumour cell suppression of immune defence pathways to escape immune recognition, and activation of proteases to promote invasion and blood vessel growth. Using unique models and cell ....Crosstalk between breast cancer cells and the microenvironment to promote metastasis. Breast cancer spread (metastasis) to distant tissues is usually fatal. It is now clear that cross-talk between cancer cells and other normal cells is essential for metastasis and previous studies have discovered two key mechanisms: tumour cell suppression of immune defence pathways to escape immune recognition, and activation of proteases to promote invasion and blood vessel growth. Using unique models and cellular imaging, this project aims to investigate the cell specific functions of these pathways and the therapeutic potential of altering their expression and function. This project may lead to the development of novel predictors of metastasis in patients and new targeted therapeutics to prevent breast cancer spread.Read moreRead less
Using mouse genetics to understand skin development and cell biology. During embryonic development the skin forms a protective barrier which permits life outside the womb and provides a window into the biology of cells. This project aims to use the skin to identify and characterise genes necessary for embryonic development and maintenance, the development of diseases and to explore their broader roles in other organs.
The virtual human knee. This project aims to investigate the Virtual Human Knee (VHK) which provides a baseline knowledge about knee mechanics in healthy individuals and a tool for studying knee mechanics in silico. The new knowledge can be used for identifying individuals most at risk for injury, developing solutions for preventing injury and for assessing knee reconstruction and implantation methods. As such, VHK will mitigate the burden of knee injury to Australia and worldwide by progressing ....The virtual human knee. This project aims to investigate the Virtual Human Knee (VHK) which provides a baseline knowledge about knee mechanics in healthy individuals and a tool for studying knee mechanics in silico. The new knowledge can be used for identifying individuals most at risk for injury, developing solutions for preventing injury and for assessing knee reconstruction and implantation methods. As such, VHK will mitigate the burden of knee injury to Australia and worldwide by progressing disciplines including anatomy, bio-mechanics, sport science, rehabilitation, surgery and medical devices.Read moreRead less
Evaluating the impact of obesity on knee load over time in those who have undergone optimal surgical re-alignment after total knee replacement . This project investigates the impact of obesity on alignment and knee load over time in those who have undergone total knee replacement. This information is critical for understanding whether obesity results in increasing knee load after surgery which can lead to more rapid wearing of the knee surfaces and an earlier need for revision surgery.
Solving the puzzle of complex disease - genes and their interactions with the environment. Many human diseases are caused by the interplay of genetic predisposition (nature) and the environment (nurture); but their causes remain a mystery, since much past research has focused on these aspects in isolation. This project will aim to better understand these complex diseases using a multi-factorial approach that brings both nature and nurture together.