Subcellular recruitment of a RhoA ubiquitination complex by Rnd proteins. This study addresses a novel molecular mechanism through which members of the Rnd family of GTP-binding proteins regulate the morphology and migration of immature nerve cells of the developing nervous system. This study has broad implications for the understanding of cell migration during embryo development, as well as in health and disease.
The critical role of kisspeptin/neurokinin/dynorphin (KNDy) neurons in gonadotropin releasing hormone (GnRH) release. The brain controls fertility through the secretion of its primary stimulatory factor, gonadotropin releasing hormone (GnRH). Brain cells producing three key peptide hormones, kisspeptin, neurokin B and dynorphin (termed KNDy cells) are vital for the control of GnRH. This project will detail the role of KNDy cells in puberty and reproduction.
Surviving the data deluge: Scalable feature extraction, discrimination and analysis for computer vision tasks using compressed sensed data. Strategically, our pioneering solutions besides being technically and socially significant, open fresh options for sensor-agnostic data analysis. The technical significance lies through the creation of new technologies for the critical national and global security markets, currently overwhelmed by data. The social significance arises from our solutions being ....Surviving the data deluge: Scalable feature extraction, discrimination and analysis for computer vision tasks using compressed sensed data. Strategically, our pioneering solutions besides being technically and socially significant, open fresh options for sensor-agnostic data analysis. The technical significance lies through the creation of new technologies for the critical national and global security markets, currently overwhelmed by data. The social significance arises from our solutions being privacy preserving, providing new avenues for the production of novel, socially acceptable products for aged care monitoring. Our methods spearhead future advancement in diverse disciplines due to the wide applicability of the methods to other sensor networks (Square Kilometre Array) and data types, providing new frameworks for addressing crucial problems of data management. Read moreRead less
Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation ....Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation of results. While theoretical developments of this project are general, in the sense that they are not restricted to particular engineering disciplines, the four chosen applications closely align with two major research priorities namely An Environmental Sustainable Australia and Promoting and Maintaining Good Health.Read moreRead less
Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their inter ....Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).Read moreRead less
Engineering cartilage homeostasis in health and disease. Arthritis is a common, painful and often debilitating disease affecting 16% of the Australian population and costing this community $11 billion every year. It is not well understood why cartilage degenerates into joint disease, nor how it may be reversed - partly due to the large number of mechanisms involved. This project aims to overcome this complexity by developing a computational model of cartilage that can integrate the various mech ....Engineering cartilage homeostasis in health and disease. Arthritis is a common, painful and often debilitating disease affecting 16% of the Australian population and costing this community $11 billion every year. It is not well understood why cartilage degenerates into joint disease, nor how it may be reversed - partly due to the large number of mechanisms involved. This project aims to overcome this complexity by developing a computational model of cartilage that can integrate the various mechanisms of cartilage degradation. New experiments will be used to validate the model and test predictions. The model developed will provide fundamental insights into what is required for the maintenance of healthy cartilage, and what happens in injury-induced degradation of cartilage.Read moreRead less
Provable elimination of information leakage through timing channels. This project aims to develop techniques to solve the issue in information security of unauthorised information flow resulting from competition for shared hardware resources. The project will combine operating systems design, formal hardware models, information-flow reasoning and theorem proving to achieve a goal that is widely considered infeasible. The project is expected to result in a system that prevents leakage of critical ....Provable elimination of information leakage through timing channels. This project aims to develop techniques to solve the issue in information security of unauthorised information flow resulting from competition for shared hardware resources. The project will combine operating systems design, formal hardware models, information-flow reasoning and theorem proving to achieve a goal that is widely considered infeasible. The project is expected to result in a system that prevents leakage of critical information, such as encryption keys, through timing channels. This should prevent sophisticated attacks on public clouds, mobile devices and military-grade cross-domain devices.Read moreRead less
A Structural Investigation Into Events Within The Immunological Synapse. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide significant fundamental insight into the processes that control infection. Investigating processes central to immunity is important, as it will further our understanding of these critically-important events. Such knowledge will increase Australia's international research standing, as well as having the potential to generat ....A Structural Investigation Into Events Within The Immunological Synapse. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide significant fundamental insight into the processes that control infection. Investigating processes central to immunity is important, as it will further our understanding of these critically-important events. Such knowledge will increase Australia's international research standing, as well as having the potential to generate novel therapies, such as immunosuppressants.Read moreRead less
An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposa ....An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposal aims to investigate, using X-ray crystallography as the primary research tool, co- receptors located on T-lymphocytes. This work will gain fundamental insights into co-receptor function.Read moreRead less
Developing Reliable Bio-Crypto Features for Mobile Template Protection. Cost of identity theft crimes were at multi-million dollars in Australia in 2007. Technically this is due to the fact that conventional personal identification number and token based security mechanisms cannot identify genuine users. Biometric fingerprint security systems emerge as a promising solution. However protection of the mobile embedded fingerprint template itself is an unresolved problem. The project aims to devel ....Developing Reliable Bio-Crypto Features for Mobile Template Protection. Cost of identity theft crimes were at multi-million dollars in Australia in 2007. Technically this is due to the fact that conventional personal identification number and token based security mechanisms cannot identify genuine users. Biometric fingerprint security systems emerge as a promising solution. However protection of the mobile embedded fingerprint template itself is an unresolved problem. The project aims to develop new ways designing bio-cryptosystems that provide strong security strength. The project will bring new body of knowledge into this field and place Australia in the forefront of this research, and also result in strengthened security of IT infrastructure and systems for industries.Read moreRead less