Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
New modulators of voltage-gated sodium channel subtypes from Australian Tarantula venoms. The venoms of Australian tarantula spiders provide a unique and untapped source of bioactive molecules. From a large stock of venom, and in collaboration with Australian pharmaceutical company Xenome, we will develop a comprehensive library of venom components suitable for drug screening. Potential national benefits from this work include a huge reduction in the healthcare bill deriving from a new treatmen ....New modulators of voltage-gated sodium channel subtypes from Australian Tarantula venoms. The venoms of Australian tarantula spiders provide a unique and untapped source of bioactive molecules. From a large stock of venom, and in collaboration with Australian pharmaceutical company Xenome, we will develop a comprehensive library of venom components suitable for drug screening. Potential national benefits from this work include a huge reduction in the healthcare bill deriving from a new treatment for pain, as well as substantial royalty returns from drugs sales. Discoveries from the program are also likely to lead to an enhancement in Australia's reputation in the neurosciences and to the development of new diagnostic research tools. The major community benefit will be a reduction in the suffering of chronic pain patients.Read moreRead less
Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and ....Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and joint estimation of physiological and metabolic organ activity. These advances will create innovative imaging technologies for advanced biomedical imaging research with a particular emphasis in healthy ageing.
Read moreRead less
Resonance: a digital media art work for cooperative group interaction in the rehabilitation of acquired brain injury. The project, titled 'resonance', encompasses the design and development of an interactive multimedia artwork for rehabilitation of Acquired Brain Injury (ABI). The artwork will promote cooperative group interaction between patients, enhancing their motor and cognitive recovery.
An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastru ....An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastructure is central to the control of such attacks and hence to a nation's long-term survival and prosperity. The outcomes of this project can be directly used in Australian research communities and adopted by industry and government agencies.Read moreRead less
Defending AI based FinTech Systems against Model Extraction Attacks. This project aims to develop new methods for defending artificial intelligence (AI) based FinTech systems from highly potent and insidious model extraction attacks whereby an adversary can steal the AI model from the system to cause intellectual property (IP) violation, business advantage disruption, and financial loss. This can be achieved by examining various attack models, creating active and utility-preserving defences, and ....Defending AI based FinTech Systems against Model Extraction Attacks. This project aims to develop new methods for defending artificial intelligence (AI) based FinTech systems from highly potent and insidious model extraction attacks whereby an adversary can steal the AI model from the system to cause intellectual property (IP) violation, business advantage disruption, and financial loss. This can be achieved by examining various attack models, creating active and utility-preserving defences, and inventing non-removable watermarks on AI models. The outcomes are new tools for securing AI-based FinTech systems before deployment and tools for IP violation forensics post-deployment. Such capabilities are beneficial by improving the security and safety of FinTech systems and other nationally critical AI systems.Read moreRead less
Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and ....Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and techniques. The expected outcomes include novel software, verified by industry partners in real world case studies, ranging from life sciences to hypersonic transport. This should provide significant benefits, including the capacity for Australian industries to access world-class supercomputing technology.Read moreRead less
Software debuggers for next generation heterogeneous supercomputers. Supercomputing underpins a wide range of areas of importance to the Australian economy; mining, agriculture, engineering and medical research to name a few. It is of critical importance that software solutions in these areas behave correctly. This project will develop software tools and techniques to help locate errors in such applications.
Design and Development of a Web-based Intelligent Multimedia Mining System. Increasing amounts of digital multimedia data in the form of video is being captured and stored. However, even the most advanced storage and retrieval techniques lack the features required to be used singly, or in combination, to fulfil a wide range of user needs and rapid access to multimedia resources, even in a very large video database. The core challenges are indeed to develop efficient, smart and intelligent web-ba ....Design and Development of a Web-based Intelligent Multimedia Mining System. Increasing amounts of digital multimedia data in the form of video is being captured and stored. However, even the most advanced storage and retrieval techniques lack the features required to be used singly, or in combination, to fulfil a wide range of user needs and rapid access to multimedia resources, even in a very large video database. The core challenges are indeed to develop efficient, smart and intelligent web-based multimedia mining in Australia and elsewhere. In this project, we will explore techniques and develop algorithms for content-based multimedia retrieval and mining in multimedia databases.Read moreRead less