Microglia and the inflammation spectrum - not just good or bad. Cell-mediated tissue clearance following brain injury is a universal mechanism. However, our understanding of the cells that perform these tasks is very limited. Our project will characterise this inflammatory response at a single-cell level using the zebrafish spinal cord as a versatile experimental model. The project is expected to strongly contribute to the molecular understanding of the mechanisms underlying debris removal and w ....Microglia and the inflammation spectrum - not just good or bad. Cell-mediated tissue clearance following brain injury is a universal mechanism. However, our understanding of the cells that perform these tasks is very limited. Our project will characterise this inflammatory response at a single-cell level using the zebrafish spinal cord as a versatile experimental model. The project is expected to strongly contribute to the molecular understanding of the mechanisms underlying debris removal and will advance innovative technologies that facilitate intellectual progress in neuroscience. It will produce new insights into the process of neuronal degeneration, promote Australia’s growing reputation as a global leader in neuroscience, and provide high quality training for early career researchers.Read moreRead less
Exploring new tools in nonlinear filtering and control. The conceptual advances with new design rules to be developed in the area of nonlinear filtering and control. Major benefits of this project will be its direct applications to state estimation and control problems in automobile, manufacturing, military hardware and medical device industries, and its increased capacity of contact research.
Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity. Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. This project aims to use the transparent and genetically amenable brain of the zebrafish, to explore new functions of microglia at the single cell level in the intact, behaving animal, through visualization of cellular components of the brain (neurons, glia, microglia, blood vessels, synapses), ....Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity. Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. This project aims to use the transparent and genetically amenable brain of the zebrafish, to explore new functions of microglia at the single cell level in the intact, behaving animal, through visualization of cellular components of the brain (neurons, glia, microglia, blood vessels, synapses), and through the genetic manipulation of synaptic density, and real time observation of microglia in the process.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100775
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Using nanostructured scaffolds to understand and engineer neuronal circuits. This project aims to understand the formation of neuronal circuits in the brain. While the role of biochemical features in the brain is well understood, it is not clear how the biophysical properties of the brain affect circuit formation. The outcomes of this project will improve our understanding of neuronal circuit formation as well as provide design rules for creating scaffolds to repair neuronal circuits after brain ....Using nanostructured scaffolds to understand and engineer neuronal circuits. This project aims to understand the formation of neuronal circuits in the brain. While the role of biochemical features in the brain is well understood, it is not clear how the biophysical properties of the brain affect circuit formation. The outcomes of this project will improve our understanding of neuronal circuit formation as well as provide design rules for creating scaffolds to repair neuronal circuits after brain damage. This project will integrate Australia’s strengths in nanotechnology and neurosciences, bringing Australian research at the forefront of neural engineering.Read moreRead less
Reliable and efficient algorithms for modelling dynamical systems from data. Mathematical and computational models are increasingly important in diverse areas of science and engineering including aircraft and automotive design, robotics, medical sensing, and biology. However, finding an accurate model remains a difficult task. This project will develop new methods to reliably find highly accurate models from recorded data.
A New Approach to High-Performance Control of Nonlinear Systems. The coming generation of robots are highly mobile and will interact significantly with their environment, each other, and human collaborators. However, this leads to highly coupled nonlinear dynamical behaviour, and achieving accurate and reliable control of these systems is pushing current control theory to breaking point. This project aims to develop a new approach to control of nonlinear systems based on contraction theory and c ....A New Approach to High-Performance Control of Nonlinear Systems. The coming generation of robots are highly mobile and will interact significantly with their environment, each other, and human collaborators. However, this leads to highly coupled nonlinear dynamical behaviour, and achieving accurate and reliable control of these systems is pushing current control theory to breaking point. This project aims to develop a new approach to control of nonlinear systems based on contraction theory and convex optimisation, extending the power of optimisation-based control from linear to non-linear systems. The project is expected to lead to new theoretical developments, constructive algorithms and software, and experimental demonstrations on a range of platforms including bipedal walking robots and underwater robots.Read moreRead less
Advanced coverage control techniques for mobile networked systems. This project aims to efficiently control individual mobile sensors and actuators to achieve network-wide coverage quality for monitoring and control of industrial and environmental processes. Coverage control of mobile networked systems is important in control engineering due to the growing use of mobile robots and mobile wireless networks for sensing coverage and monitoring. The project will develop techniques for coverage contr ....Advanced coverage control techniques for mobile networked systems. This project aims to efficiently control individual mobile sensors and actuators to achieve network-wide coverage quality for monitoring and control of industrial and environmental processes. Coverage control of mobile networked systems is important in control engineering due to the growing use of mobile robots and mobile wireless networks for sensing coverage and monitoring. The project will develop techniques for coverage control of mobile networks which are expected to solve industrial control problems in the defence, communications and robotics industries and manage the environment.Read moreRead less
Control and state estimation in the next-generation interconnected systems. This project aims to develop a systematic and efficient approach to address fundamental challenges in control and secure state estimation in the next-generation interconnected systems. Control and state estimation in high-tech systems is an emerging area of control engineering. The importance of this area is quickly increasing due to the growing use of the next-generation interconnected systems, in which physical and hig ....Control and state estimation in the next-generation interconnected systems. This project aims to develop a systematic and efficient approach to address fundamental challenges in control and secure state estimation in the next-generation interconnected systems. Control and state estimation in high-tech systems is an emerging area of control engineering. The importance of this area is quickly increasing due to the growing use of the next-generation interconnected systems, in which physical and high-tech components are interacting in complex networks. The project is expected to have direct applications in the management of energy networks, and in industrial control and secure state estimation problems in the defence, communications, and automobile industries.Read moreRead less
Estimation of Complex Networked Dynamic Systems. An essential part of science and engineering is the development of mathematical models to describe how observed quantities relate to one another. For example, such models have proven to be extremely powerful in predicting the value of financial instruments, in providing high performance control of robots, and in detecting faults or changes in petrochemical processing plants. Constructing these models based on measurements from the system itself is ....Estimation of Complex Networked Dynamic Systems. An essential part of science and engineering is the development of mathematical models to describe how observed quantities relate to one another. For example, such models have proven to be extremely powerful in predicting the value of financial instruments, in providing high performance control of robots, and in detecting faults or changes in petrochemical processing plants. Constructing these models based on measurements from the system itself is known as system identification. This project is directed at developing new system identification methods for situations that, on the one hand, have previously been considered unsolvable, and on the other, are acknowledged as being of high practical interest.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100922
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Diamond cybernetics: nanocrystalline diamond for interfacing bionic devices with the human nervous system. Bionic devices will soon be used to treat disorders such as epilepsy, Parkinson's and depression. We will use diamond to create high resolution, permanent electrical connections between devices and the human nervous system. These diamond connections will preserve nerve health and make bionic devices more effective and able to last a lifetime.